Endothelin A receptor antibody

Principal name

Endothelin A receptor antibody

Alternative names for Endothelin A receptor antibody

Endothelin-1 receptor, hET-AR, ETA-R, ET-A, EDNRA, ETA, ETRA, endothelin receptor type A

SwissProt ID

P21450 (Bovin), P25101 (Human), P26684 (Rat), Q29010 (Pig), Q61614 (Mouse), Q95L55 (Sheep)

Gene ID

1909 (EDNRA), 24326 (Ednra)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Sh (Sheep), Mky (Monkey), Can (Canine), Eq (Equine), Hst (Hamster), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse, Sheep

Available applications

Paraffin Sections (P), Enzyme Immunoassay (E), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Flow Cytometry (F)

Background of Endothelin A receptor antibody

The endothelin system is comprised of three active peptides, ET-1, 2, and 3, which are considered to be very powerful vasoconstrictive substances. In humans, endothelins mediate their actions via two specific G-Protein Coupled Receptors, ETAR and ETBR. Both ETAR and ETBR are present in heart and in human myocardium at similar levels. The endothelin receptors differ in their ligand specificity. While ETAR has varying affinities for the endothelin isoforms (ET-1 >ET-2>ET-3), ETBR shows no selective affinity. Subsequent studies have demonstrated the presence of endothelins in vascular as well as in non-vascular cells and tissues, having multiple biological activities. Currently, there is increasing evidence that ET-1 may modulate mitogenesis, apoptosis, angiogenesis tumor invasion and the development of metastases. Overexpression of ET-1 and ETAR was reported in different maligncies including prostate cancer human Kaposiâ??s sarcoma, ovarian and breast carcinomas. In breast carcinomas overexpression of ET-1 and ETA receptors correlated with parameters that characterize aggressive types of breast cancer suggesting that alysis of ETAR expression might be used as a diagnostic marker for evaluating the progression of the disease and effectiveness of treatment. These and other findings have made ET receptors, and especially ETAR, promising therapeutic targets for pharmacological intervention.

General readings

Wulfing P, Diallo R, Kersting C, Wulfing C, Poremba C, Greb RR, Bocker W, Kiesel L. Endothelin-1, Endothelin-A- and Endothelin-B-receptor expression in preinvasive and invasive breast disease. Oncol Rep. 2004 Apr;11(4):791-6.
2 Siren AL, Knerlich F, Schilling L, Kamrowski-Kruck H, Hahn A, Ehrenreich H. Differential glial and vascular expression of endothelins and their receptors in rat brain after neurotrauma. Neurochem Res. 2000 Jul;25(7):957-69.
3 Shraga-Levine Z, Sokolovsky M. Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific. Cell Mol Neurobiol. 2000 Jun;20(3):305-17.
4 Fernandes LB, Henry PJ, Spalding LJ, Cody SH, Pudney CJ, Goldie RG. Immunocytochemical detection of endothelin receptors in rat cultured airway nerves. J Cardiovasc Pharmacol. 1998;31 Suppl 1:S222-4.
5 Barber DA, Michener SR, Ziesmer SC, Miller VM. Chronic increases in blood flow upregulate endothelin-B receptors in arterial smooth muscle. Am J Physiol. 1996 Jan;270(1 Pt 2):H65-71

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Endothelin A receptor antibody

Western blot analysis of extracts from HepG2 cells, using EDNRA antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Endothelin A receptor antibody

Western blot analysis of extracts from COS-7 cells, using EDNRA antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Endothelin A receptor antibody

Western blot analysis of EDNRA antibody (Center) (Cat.# TA324844) in CEM cell line lysates (35ug/lane). EDNRA (arrow) was detected using the purified Pab. Rabbit Hu F, ICC/IF, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Endothelin A receptor antibody

Western blot analysis of rat brain membranes: 1. Anti-Endothelin Receptor A antibody, (1:200). 2. Anti-Endothelin Receptor A antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Endothelin A receptor (N-term, Extracel. Dom.) antibody

Anti-Endothelin A Receptor antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Aff - Purified Bov, Bt, Can, Elephant, Eq, Hu, Mky, Prim, Sh P
50 µg / €379.00
  OriGene Technologies, Inc.

Endothelin A receptor (3rd Extracell. Dom.) antibody

Anti-Endothelin A Receptor antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Aff - Purified Bear, Bov, Bt, Can, Eq, Fi, Hst, Hu, Mky, Ms, Op, Platypus, Por, Prim, Rb, Rt, Sh P
50 µg / €379.00
  OriGene Technologies, Inc.

Endothelin A receptor (C-term) antibody

Anti-Endothelin A Receptor antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Aff - Purified Bear, Bov, Bt, Can, Chk, Eq, Hst, Hu, Mky, Ms, Op, Platypus, Por, Prim, Rb, Sh, Tr P
50 µg / €379.00
  OriGene Technologies, Inc.

Endothelin A receptor (2nd Extracell. Dom) antibody

Anti-Endothelin A Receptor antibody IHC of human heart, cardiac myocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bov, Bt, Can, Elephant, Eq, Hst, Hu, Mky, Ms, Platypus, Por, Prim, Rb, Rt, Sh P
50 µg / €379.00
  OriGene Technologies, Inc.

Endothelin A receptor antibody

ELISA: Endothelin A Receptor Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

Endothelin A receptor antibody

Western blot analysis of ETAR antibody (Cat.-No AP01200PU-N) in extracts from HepG2 cells. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Endothelin A receptor antibody

Figure 1. Western blot (WB) analysis of ETAR antibody (Cat.-No.: AP01426PU-N) in extracts from COS7 cells. Rabbit Aff - Purified Hu, Ms, Rt C, ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Endothelin A receptor (C-term) antibody

Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Endothelin A receptor antibody

Endothelin A receptor Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

Endothelin A receptor antibody

Western Blot analysis of EDNRA expression in transfected 293T cell line by EDNRA monoclonal antibody (M02), clone 2A5.

Lane 1: EDNRA transfected lysate(48.7 KDa).
Lane 2: Non-transfected lysate. Mouse IgG2a 2A5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Endothelin A receptor antibody

Immunofluorescence analysis of COS7 cells, using EDNRA Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
50 µg / €205.00
  Assay Biotech

Endothelin A receptor antibody

Immunofluorescence analysis of COS7 cells, using EDNRA Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €310.00
  Assay Biotech

Endothelin A receptor antibody

Immunofluorescence analysis of LOVO cells, using EDNRA Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, ICC/IF, WB
50 µg / €205.00
  Assay Biotech

Endothelin A receptor antibody

Immunofluorescence analysis of LOVO cells, using EDNRA Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €310.00
  Assay Biotech

Endothelin A receptor antibody

Immunohistochemical analysis of Endothelin A Receptor staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Endothelin A receptor antibody

Immunohistochemical analysis of Endothelin A Receptor staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

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