Endothelin A receptor antibody

Principal name

Endothelin A receptor antibody

Alternative names for Endothelin A receptor antibody

Endothelin-1 receptor, hET-AR, ETA-R, ET-A, EDNRA, ETA, ETRA, endothelin receptor type A

SwissProt ID

P21450 (Bovin), P25101 (Human), P26684 (Rat), Q29010 (Pig), Q61614 (Mouse), Q95L55 (Sheep)

Gene ID

1909 (EDNRA), 24326 (Ednra), 13617

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bt (Bat), Bov (Bovine), Can (Canine), Eq (Equine), Mky (Monkey), Prim (Primate), Sh (Sheep), Fi (Fish), Hst (Hamster), Op (Opossum), Por (Porcine), Rb (Rabbit), Bear, Chk (Chicken), Tr (Turkey)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Frozen Sections (C), Flow Cytometry (F)

Background of Endothelin A receptor antibody

The endothelin system is comprised of three active peptides, ET-1, 2, and 3, which are considered to be very powerful vasoconstrictive substances. In humans, endothelins mediate their actions via two specific G-Protein Coupled Receptors, ETAR and ETBR. Both ETAR and ETBR are present in heart and in human myocardium at similar levels. The endothelin receptors differ in their ligand specificity. While ETAR has varying affinities for the endothelin isoforms (ET-1 >ET-2>ET-3), ETBR shows no selective affinity. Subsequent studies have demonstrated the presence of endothelins in vascular as well as in non-vascular cells and tissues, having multiple biological activities. Currently, there is increasing evidence that ET-1 may modulate mitogenesis, apoptosis, angiogenesis tumor invasion and the development of metastases. Overexpression of ET-1 and ETAR was reported in different maligncies including prostate cancer human Kaposiâ??s sarcoma, ovarian and breast carcinomas. In breast carcinomas overexpression of ET-1 and ETA receptors correlated with parameters that characterize aggressive types of breast cancer suggesting that alysis of ETAR expression might be used as a diagnostic marker for evaluating the progression of the disease and effectiveness of treatment. These and other findings have made ET receptors, and especially ETAR, promising therapeutic targets for pharmacological intervention.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Endothelin A receptor antibody

  Rabbit polyclonal anti-EDNRA antibody  
Western blot analysis of extracts from HepG2 cells, using EDNRA antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Endothelin A receptor antibody

  Rabbit polyclonal anti-EDNRA antibody  
Western blot analysis of extracts from COS-7 cells, using EDNRA antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Endothelin A receptor antibody

  Rabbit polyclonal EDNRA Antibody (Center)  
Western blot analysis of EDNRA antibody (Center) (Cat.# TA324844) in CEM cell line lysates (35ug/lane). EDNRA (arrow) was detected using the purified Pab. Rabbit Hu F, ICC/IF, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Endothelin A receptor antibody

  Rabbit Polyclonal Anti-Endothelin Receptor A  
Western blot analysis of rat brain membranes: 1. Anti-Endothelin Receptor A antibody, (1:200). 2. Anti-Endothelin Receptor A antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Endothelin A receptor (N-term, Extracel. Dom.) antibody

  Rabbit Polyclonal Anti-EDNRA Antibody (N-Terminus)  
Anti-Endothelin A Receptor antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Aff - Purified Bov, Bt, Can, Elephant, Eq, Hu, Mky, Prim, Sh P
50 µg / €400.00
  OriGene Technologies, Inc.

Endothelin A receptor (3rd Extracell. Dom.) antibody

  Rabbit Polyclonal Anti-EDNRA Antibody (Extracellular Domain)  
Anti-Endothelin A Receptor antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Aff - Purified Bear, Bov, Bt, Can, Eq, Fi, Hst, Hu, Mky, Ms, Op, Platypus, Por, Prim, Rb, Rt, Sh P
50 µg / €400.00
  OriGene Technologies, Inc.

Endothelin A receptor (C-term) antibody

  Rabbit Polyclonal Anti-EDNRA Antibody (C-Terminus)  
Anti-Endothelin A Receptor antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Aff - Purified Bear, Bov, Bt, Can, Chk, Eq, Hst, Hu, Mky, Ms, Op, Platypus, Por, Prim, Rb, Sh, Tr P
50 µg / €400.00
  OriGene Technologies, Inc.

Endothelin A receptor (2nd Extracell. Dom) antibody

  Rabbit Polyclonal Anti-EDNRA Antibody (Extracellular Domain)  
Anti-Endothelin A Receptor antibody IHC of human heart, cardiac myocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bov, Bt, Can, Elephant, Eq, Hst, Hu, Mky, Ms, Platypus, Por, Prim, Rb, Rt, Sh P
50 µg / €400.00
  OriGene Technologies, Inc.

Endothelin A receptor antibody

  Rabbit Polyclonal Anti-EDNRA Antibody  
Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane: MCF7 cells, Primary antibody: (EDNRA Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Endothelin A receptor antibody

  Rabbit Polyclonal Endothelin A Receptor Antibody  
ELISA: Endothelin A Receptor Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

Endothelin A receptor antibody

Western blot analysis of ETAR antibody (Cat.-No AP01200PU-N) in extracts from HepG2 cells. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Endothelin A receptor antibody

Figure 1. Western blot (WB) analysis of ETAR antibody (Cat.-No.: AP01426PU-N) in extracts from COS7 cells. Rabbit Aff - Purified Hu, Ms, Rt C, ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Endothelin A receptor (C-term) antibody

Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Endothelin A receptor antibody

Immunofluorescence analysis of COS7 cells, using EDNRA Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
50 µg / €230.00
  Assay Biotech

Endothelin A receptor antibody

Immunofluorescence analysis of COS7 cells, using EDNRA Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €330.00
  Assay Biotech

Endothelin A receptor antibody

Immunofluorescence analysis of LOVO cells, using EDNRA Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, ICC/IF, WB
50 µg / €230.00
  Assay Biotech

Endothelin A receptor antibody

Immunofluorescence analysis of LOVO cells, using EDNRA Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

EDNRA - human gene knockout kit via CRISPR

EDNRA - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

EDNRA - human gene knockout kit via CRISPR

EDNRA - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

EDNRA - human gene knockout kit via CRISPR

EDNRA - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

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