ENPP1 antibody

Principal name

ENPP1 antibody

Alternative names for ENPP1 antibody

ENPP-1, M6S1, NPPS, PC1, PDNP1, E-NPP 1, Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, Phosphodiesterase I/nucleotide pyrophosphatase 1, Plasma-cell membrane glycoprotein PC-1

SwissProt ID

P06802 (Mouse), P22413 (Human), P90754 (Caeel), Q924C3 (Rat)

Gene ID

5167 (ENPP1), 85496 (Enpp1)

Available reactivities

Hu (Human), Bt (Bat), Bov (Bovine), Eq (Equine), Fi (Fish), Hst (Hamster), Mky (Monkey), Ms (Mouse), Op (Opossum), Prim (Primate), Rb (Rabbit), Rt (Rat), Shrew, Bear

Available hosts

Goat, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Frozen Sections (C)

Background of ENPP1 antibody

ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase family member 1) is a type II transmembrane glycoprotein which is implicated in membrane surface ATP hydrolysis, regulation of pyrophosphate levels, bone mineralization as well as soft tissue calcification. ENPP1 negatively regulates bone mineralization by hydrolyzing extracellular nucleotide triphosphates (NTPs) to produce inorganic pyrophosphate (PPi, an inhibitor of mineralization), whereas tissue-nonspecific ALP positively regulates mineralization by hydrolyzing NTPs and PPi to produce extracellular concentrations of inorganic phosphate (Pi, a substrate for mineralization). ENPP1 is expressed on outer surfaces of mineralizing cells, such as osteoblasts and chondrocytes, and on the membranes of osteoblast- and chondrocyte-derived matrix vesicles. It also hydrolyzes other NTPs such as GTP, CTP, TTP, UTP etc. to their corresponding monophosphates with the release of PPi and diadenosine polyphosphates, and also 3',5'-cAMP to AMP, and may also regulate the availability of nucleotide sugars in ER/Golgi complex, as well as the regulation of purinergic sigling. ENPP1 binds directly to INSR for inhibiting insulin sigling and ENPP1's K173Q/ K121Q polymorphism is associated with insulin resistance, NIDDM, and obesity. Defective ENPP1 causes increased susceptibility for ossification of the posterior longitudil ligament of spine (OPLL), arterial calcification of infancy, generalized, type 1 (GACI1), obesity/glucose intolerance/NIDDM, and rickets hypophosphatemic autosomal recessive type 2 (ARHR2).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ENPP1 (C-term) antibody

  Goat Anti-ENPP1 / PC1 Antibody  
HEK293 overexpressing Human ENPP1 (RC209222) and probed with TA311356 (mock transfection in first Lane). Goat IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ENPP1 antibody

  Goat Polyclonal ENPP-1 Antibody  
Immunohistochemistry: ENPP1 Antibody [TA336693] -  ENPP1 antibody was tested in human liver using DAB with hematoxylin counterstain. Goat Purified Hu C, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ENPP1 (915-925) antibody

Formalin-Fixed Paraffin-Embedded Human Pancreas stained with anti-ENPP1 Antibody Cat.-No AP08594PU-N at 5 µg/ml after heat-induced antigen retrieval. Goat IgG Aff - Purified Armadillo, Bear, Bov, Bt, Elephant, Eq, Fi, Hst, Hu, Mky, Ms, Op, Prim, Rb, Rt, Shrew E, P
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

ENPP1 - human gene knockout kit via CRISPR

ENPP1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

ENPP1 - human gene knockout kit via CRISPR

ENPP1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

ENPP1 - human gene knockout kit via CRISPR

ENPP1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

ENPP1 - human gene knockout kit via CRISPR

ENPP1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ENPP1

  Recombinant protein of human ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1)  
ENPP1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Lysates

Catalog No.    

ENPP1 overexpression lysate

ENPP1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

ENPP1 overexpression lysate

ENPP1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, ENPP1 (mGFP-tagged) - Human ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), 200 uL, >10^7 TU/mL

Lenti ORF particles, ENPP1 (mGFP-tagged) - Human ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, ENPP1 (Myc-DDK tagged) - Human ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) , 200 uL, >10^7 TU/mL

Lenti ORF particles, ENPP1 (Myc-DDK tagged) - Human ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, ENPP1 (Myc-DDK tagged) - Human ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), 200 uL, >10^7 TU/mL

Lenti ORF particles, ENPP1 (Myc-DDK tagged) - Human ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Enpp1 (GFP-tagged ORF) - Rat ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Enpp1 (GFP-tagged ORF) - Rat ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1), 200 uL, >10^7 TU/mL  
200 µl / €1,650.00
  OriGene Technologies, Inc.

Lenti ORF particles, Enpp1 (Myc-DDK-tagged ORF) - Rat ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Enpp1 (Myc-DDK-tagged ORF) - Rat ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1), 200 uL, >10^7 TU/mL  
200 µl / €1,488.00
  OriGene Technologies, Inc.

15 Item(s)

per page
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