EPHB3 antibody

Principal name

EPHB3 antibody

Alternative names for EPHB3 antibody

Ephrin type-B receptor 3, ETK2, HEK2, TYRO6, Tyrosine-protein kinase receptor HEK-2, Tyrosine-protein kinase TYRO6

SwissProt ID

P54753 (Human), P54754 (Mouse), Q07498 (Chick), Q91735 (Xenla)

Gene ID

2049 (EPHB3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Chk (Chicken), Por (Porcine), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Frozen Sections (C)

Background of EPHB3 antibody

The membrane bound Ephrins are ligands for Ephrin receptor tyrosine kinases that regulate several physiological functions including long-term potentiation, cell positioning, CNS development and axonal path finding and mitogenesis etc. Ephrins molecules exhibit the ability to send bidirectional signals following ligand-receptor interactions resulting from cell-cell contacts. Activation of Eph receptors are also shown to regulate transduction pathways important in cell cycle control as well as cell death. There are at least 4 different kinds of Ephrin B receptors are cloned (Ephrin B1R-Ephrin B4R). EphB receptor tyrosine kinases and ephrin-B ligands also regulate several types of cell-cell interactions during brain development, generally by modulating the cytoskeleton. EphB/ephrinB genes are expressed in the developing neural tube of early mouse embryos with distinct overlapping expression in the ventral midbrain. The positioning of cells within the stem cell niche in the intestinal epithelium is controlled by B subclass ephrins through their interaction with EphB receptors. Ephrin 3 ligands are also known as guidance molecule as they are mainly responsible for positioning and directing the cell migration along the villus-crypt axis in intestine. Ephrin 3 by interacting with ephrin B3 receptors in conjunction with Wnt proteins signals and promotes cell cycle re-entry of proginator cells and accounts for 50% of the mitogenic activity. The Ephrin B receptors are the key coordinators of the intestinal stem cell niche (1).
Ephrin B3 ligands are highly expressed in the mossy fibers axons and terminals and the Ephrins B3 receptors are expressed on post-synaptic neurons. Ephrin-B3 promotes adhesion of hippocampal neurons to the ligand-expressing substrates in vitro, and the loss of the receptor or EphB2 abrogates the effects of ephrin-B3 (2). The function of Ephrins in the immune system has not been well studied, although some Ephrins and Ephrin receptors are expressed at high levels on certain leukocytes. EFNB3 and its cognate receptors are expressed in peripheral T cells and monocytes/macrophages. The role of EphR2 and EphR4 in angiogenesis and formation of arteries and veins come form findings that EphR2 marks arteries but not veins and conversely, the EphR4 labels exclusively the veins (3).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

EPHB3 antibody

  Rabbit Polyclonal Anti-EPHB3 Antibody  
WB Suggested Anti-EPHB3 Antibody; Titration: 1.0 ug/ml; Positive Control: HT1080 Whole Cell Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

EPHB3 antibody

Immunohistochemical analysis of paraffin-embedded human lung squamous cell carcinoma (A), lung adenocarcinoma (B), colon carcinoma (C), breast carcinoma (D), normal sublingual gland (E), normal rectal (F), showing membrane localization with DAB staining using EphB3 antibody Cat.-No AM06222SU-N Mouse IgG2a 4A122D1 Ascites Hu E, P, WB
0.1 ml / €440.00
  Acris Antibodies GmbH

EPHB3 (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

EPHB3 antibody

EPHB3 Rabbit Serum Hu, Ms C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

EPHB3

  Recombinant protein of human EPH receptor B3 (EPHB3)  
EPHB3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

EPHB3 (C-term DDK/His tag)

  Purified recombinant protein of human EPH receptor B3 (EPHB3), with C-terminal DDK/His tag, expressed in human cells, 20 µg  
EPHB3 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

EPHB3 (C-term DDK tag)

  Purified recombinant protein of Human EPH receptor B3 (EPHB3), residues 34-559aa, with C-terminal DDK tag, expressed in sf9, 20ug  
EPHB3 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
20 µg / €399.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

EPHB3 overexpression lysate

EPHB3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, EPHB3 (mGFP-tagged) - Human EPH receptor B3 (EPHB3), 200 uL, >10^7 TU/mL

Lenti ORF particles, EPHB3 (mGFP-tagged) - Human EPH receptor B3 (EPHB3), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, EPHB3 (Myc-DDK tagged) - Human EPH receptor B3 (EPHB3) , 200 uL, >10^7 TU/mL

Lenti ORF particles, EPHB3 (Myc-DDK tagged) - Human EPH receptor B3 (EPHB3) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

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