EPHB6 antibody

Principal name

EPHB6 antibody

Alternative names for EPHB6 antibody

Ephrin type-B receptor 6, EPH-6, HEP, Tyrosine-protein kinase-defective receptor EPH-6

SwissProt ID

O08644 (Mouse), O15197 (Human), P0C0K7 (Rat)

Gene ID

2051 (EPHB6), 13848 (Ephb6), 4205186 (Q0SRK7)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Mky (Monkey)

Available hosts

Mouse, Goat, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Immunoprecipitation (IP)

Background of EPHB6 antibody

EphB6, also known as Mep, is a member of the Eph receptor family, which binds members of the Ephrin ligand family. Two classes of receptors exist, designated A and B, that have an extracellular domain made up of a globular domain, a cysteine-rich domain, and two fibronectin type III domains, followed by the transmembrane region and cytoplasmic region. The cytoplasmic region is a juxtamembrane region with two tyrosines, the major autophosphorylation sites, along with a kinase domain, and a conserved sterile alpha motif (SAM) in the C-terminus, the latter including one conserved tyrosine. The extracellular domains of human and mouse EphB6 share 92% amino acid identity. The calculated molecular mass of the reduced mouse EphB6/Fc monomer is 87.3 kDa, but as a result of glycosylation, recombinant EphB6/Fc migrates as an approximately 100 kDa protein under reducing conditions in SDS-PAGE. EphB6 lacks intrinsic kinase activity, however, crosslinking of the Eph6 receptor leads to activation of the cellular kinase activity. EphB6 binds to Ephrin-B2 and Ephrin B3.5 Only membrane-bound or Fc-clustered ligands have been shown to activate the receptor in vitro. Soluble monomeric ligands bind the receptor, butdo not induce receptor autophosphorylation and activation. The ephrin ligands and Eph receptors display reciprocal expression in vivo. Developing and adult neural tissue express nearly all of the Eph receptors and ephrin ligands. Ephs and ephrins play significant role in angiogenesis.

General readings

1. Stark DA  et al. Eph/ephrin interactions modulate muscle satellite cell motility and patterning. Development 138:5279-89 (2011). Flow Cyt, IHC (PFA fixed) ; Mouse .

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

EPHB6 antibody

Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 5D8 Purified Hu, Ms, Rt E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

EPHB6 antibody

Immunoperoxidase of monoclonal antibody to EPHB6 on formalin-fixed paraffin-embedded human pancreas. [antibody concentration 3 ug/ml] Mouse IgG2a 5D8 Purified Hu, Ms, Rt E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

EPHB6 antibody

Western blot analysis of extracts from HeLa cells, 293 cells and COLO cells, using EPHB6 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

EPHB6 antibody

ELISA: EPH receptor B6 Antibody Rabbit IgG Purified Hu E
50 µg / €325.00
  OriGene Technologies, Inc.

EPHB6 antibody

Immunohistochemical analysis of paraffin-embedded human lymph node (left) and brain (right), showing cytoplasmic localization with DAB staining using EhpB6 antibody Cat.-No AM06213SU-N Mouse IgG1 2A6B9 Ascites Hu E, P, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

EPHB6 (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

EPHB6 (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

EPHB6 antibody

Immunohistochemistry (IHC) analyzes of EphB6 antibody (Cat.-No.: AP20511PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

EPHB6 (831-843) antibody

Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat IgG Aff - Purified Bear, Can, Eq, Hu, Mky, Ms, Por, Prim, Rb, Rt P
50 µg / €470.00
  Acris Antibodies GmbH

EPHB6 antibody

EPHB6 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

EPHB6 antibody

EPHB6 monoclonal antibody (M01), clone 5H6 Western Blot analysis of EPHB6 expression in PC-12 ( Cat # L012V1 ). Mouse IgG2a 5H6 Purified Hu, Rt E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

EPHB6 antibody

Detection limit for recombinant GST tagged EPHB6 is approximately 1ng/ml as a capture antibody. Mouse IgG2a 3B6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

EPHB6 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with EPHB6 polyclonal antibody ( Cat # PAB2074 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

EPHB6 antibody

EPHB6 Rabbit Hu C, E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

EPHB6 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using EPHB6 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €205.00
  Assay Biotech

EPHB6 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using EPHB6 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €310.00
  Assay Biotech

EPHB6 antibody

Western blot analysis of EPHB6 expression in Jurkat (A) whole cell lysates. Rabbit Aff - Purified Hu, Mky, Ms, Rt IP, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

EPHB6 antibody

Western blot analysis of EPHB6 expression in Jurkat (A) whole cell lysates. Rabbit Aff - Purified Hu, Mky, Ms, Rt IP, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

EPHB6 antibody

Western blot analysis of EPHB6 expression in Jurkat (A) whole cell lysates. Rabbit Aff - Purified Hu, Mky, Ms, Rt IP, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

EPHB6 antibody

ELISA: EPH receptor B6 Antibody [36150002] Rabbit Hu E, WB
50 µg / €400.00
  Novus Biologicals Inc.

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