ERBB3 / HER3 antibody

Principal name

ERBB3 / HER3 antibody

Alternative names for ERBB3 / HER3 antibody

ERBB-3, c-erbB-3, HER-3, Receptor tyrosine-protein kinase erbB-3, Tyrosine kinase-type cell surface receptor HER3, Proto-oncogene-like protein c-ErbB-3

SwissProt ID

P21860 (Human), Q5RB22 (Ponab), Q61526 (Mouse), Q62799 (Rat)

Gene ID

2065 (ERBB3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P), Western blot / Immunoblot (WB), Flow Cytometry (F), ELISA (detection) (E(detection))

Background of ERBB3 / HER3 antibody

ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. Isoform 2 lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized. Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2); also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord.

General readings

1. Vijapurkar, U., et al. (1999) The ErbB3/HER3 receptor protein: signaling mechanisms and biologic function.
Curr. Top. Biochem. Res. 1999 ; 1: 37-57
2. Liu Z, et al., (2001) Expression of the receptor tyrosine kinases, epidermal growth factor receptor, ErbB2, and ErbB3, in human ocular surface epithelia.
Cornea. 20(1):81-5.
3. Goodearl A, et al., (2001) Neuregulin-Induced Association of Sos Ras Exchange Protein with HER2(erbB2)/HER3(erbB3) Receptor Complexes in Schwann Cells through a Specific Grb2-HER2(erbB2) Interaction.
Dev Neurosci. 23(1):25-30.
4. Krahn G et al., (2001) Coexpression patterns of EGFR, HER2, HER3 and HER4 in non-melanoma skin cancer. Eur J Cancer. 37(2):251-9
5. Garratt AN et al., (2000) Neuregulin, a factor with many functions in the life of a schwann cell. Bioessays. 22(11):987-96. Review.

  1. Quick-Filters:
  2. Highly Validated (7)
  3. Overnight Delivery (3)

Items 1 to 20 of 98 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ERBB3 / HER3 antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-ERBB3 Rabbit Polyclonal antibody. (TA590106) Rabbit IgG Purified Hu P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

ERBB3 / HER3 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-ERBB3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA803694) Mouse IgG2b OTI3E10 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

ERBB3 / HER3 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-ERBB3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA809228)(1:150) Mouse IgG1 OTI3C1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

ERBB3 / HER3 antibody

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 2E9 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

ERBB3 / HER3 pTyr1328 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Her3/ErbB3 pTyr1328 Antibody (#AP08032PU). Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

ERBB3 / HER3 pTyr1328 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Her3/ErbB3 pTyr1328 Antibody (#AP08032PU). Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
50 µl / €240.00
  Acris Antibodies GmbH

ERBB3 / HER3 pTyr1328 antibody

Immunohistochemistry: Her3/ErbB3 phosphospecific Antibody [NBP1-04970] - Immunohistochemical analysis of paraffin-embedded  human breast carcinoma tissue using Her3/ErbB3  (phospho-Tyr1328) Antibody Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

ERBB3 / HER3 antibody

AM09108PU c-erbB3 antibody staining of Human Small Intestine. Rabbit IgG SP71 Purified Hu P
0.5 ml / €520.00
  Acris Antibodies GmbH

ERBB3 / HER3 antibody

AM09108PU c-erbB3 antibody staining of Human Small Intestine. Rabbit IgG SP71 Purified Hu P

Regular Price: 1 ml / €730.00

Special Price: 1 ml / €399.00

  Acris Antibodies GmbH

ERBB3 / HER3 antibody

AM09108PU c-erbB3 antibody staining of Human Small Intestine. Rabbit IgG SP71 Purified Hu P
0.1 ml / €290.00
  Acris Antibodies GmbH

ERBB3 / HER3 antibody

Human colon carcinoma stained with anti-c-erbB3 antibody Rabbit Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

ERBB3 / HER3 antibody

Human colon carcinoma stained with anti-c-erbB3 antibody Rabbit Purified Hu P

Regular Price: 0.2 ml / €200.00

Special Price: 0.2 ml / €140.00

  Acris Antibodies GmbH

ERBB3 / HER3 (Isoform 1) (C-term) antibody

TA303054 (0.1µg/ml) staining of Jurkat lysate (35µg protein in RIPA buffer) with (B) and without (A) blocking with the immunising peptide.  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt WB
20 µg / €200.00
  Acris Antibodies GmbH

ERBB3 / HER3 (Isoform 1) (C-term) antibody

TA303054 (0.1µg/ml) staining of Jurkat lysate (35µg protein in RIPA buffer) with (B) and without (A) blocking with the immunising peptide.  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ERBB3 / HER3 antibody

Western blot analysis of extracts from COLO205 cells, using HER3 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ERBB3 / HER3 antibody

CoIP and WB of a human cell lysate using anti-HER3 antibody. Lysates were prepared from a human LNCap prostate cell line both with (+) treatment with  Heregulin-b1 for 15' at 100 ng/ml and without (-) the addition of Heregulin-b1.  The combination of IP and WBting was performing using 5 µl of the anti-HER3 antibody for IP followed by WB detection using an anti-phosphotyrosine antibody. Visualization occurred using an ECL system.  Film exposure approximately 1’. Rabbit Purified Hu, Ms, Rt IP, WB
0.25 mg / €325.00
  OriGene Technologies, Inc.

ERBB3 / HER3 antibody

Predicted cell location: Cytoplasm, Cell membrane. Positive control: Human colon cancer tissue. Recommended dilution: 1/50-150  The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using ERBB3 antibody at dilution 1/35, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

ERBB3 / HER3 antibody

Predicted cell location: Cytoplasm . Positive control: Human colon cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using ERBB3 antibody at dilution 1/20, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

ERBB3 / HER3 antibody

Western blot analysis of extracts of A431 cell line, using ERBB3 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

ERBB3 / HER3 antibody

Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-ERBB3 mouse monoclonal antibody. (TA803687) Dilution: 1:150 Mouse IgG1 OTI2F11 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Items 1 to 20 of 98 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
  • LinkedIn