ERBB3 / HER3 antibody

Principal name

ERBB3 / HER3 antibody

Alternative names for ERBB3 / HER3 antibody

ERBB-3, c-erbB-3, HER-3, Receptor tyrosine-protein kinase erbB-3, Tyrosine kinase-type cell surface receptor HER3, Proto-oncogene-like protein c-ErbB-3

SwissProt ID

P21860 (Human), Q5RB22 (Ponab), Q61526 (Mouse), Q62799 (Rat)

Gene ID

2065 (ERBB3), 13867 (Erbb3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bt (Bat), Bov (Bovine), Eq (Equine), Hst (Hamster), Mky (Monkey), Por (Porcine), Prim (Primate), Bear, Can (Canine)

Available hosts

Rabbit, Mouse, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Flow Cytometry (F), ELISA (detection) (E(detection)), Frozen Sections (C), Immunoprecipitation (IP)

Background of ERBB3 / HER3 antibody

The human Epidermal Growth Factor Receptor (EGFR) family is a family of receptor tyrosine kinases consisting of 4 members: EGFR, HER2, HER3 and HER4. These receptors are expressed on a wide variety of tissue types and have been implicated in many human cancers, including breast, gastric, colon and prostate. Strong expression of both HER3 and HER2 (also known as p185neu) by tumor cells can be associated with poor outcome for patients. The ligand for HER3 and HER4 is called Neu Differentiation Factor (NDF) or Heregulin. In some instances, antibodies against these receptors prove effective in combination therapy regimens for treatment of the disease. Signaling through the EGFR family involves the combinatorial dimerization of the four known family members and is mediated by at least 8 different hormones, including EGF and the heregulins. Heregulin binding and tyrosine phosphorylation by HER3 or HER4 is enhanced in the presence of HER2. Structurally the members of the EGFR family are 1210 to 1342 amino acids in length with approximately 650 amino acids of the extracellular domain being heavily glycosylated. The extracellular domains show up to 70% sequence homology.

General readings

1. Vijapurkar, U., et al. (1999) The ErbB3/HER3 receptor protein: signaling mechanisms and biologic function.
Curr. Top. Biochem. Res. 1999 ; 1: 37-57
2. Liu Z, et al., (2001) Expression of the receptor tyrosine kinases, epidermal growth factor receptor, ErbB2, and ErbB3, in human ocular surface epithelia.
Cornea. 20(1):81-5.
3. Goodearl A, et al., (2001) Neuregulin-Induced Association of Sos Ras Exchange Protein with HER2(erbB2)/HER3(erbB3) Receptor Complexes in Schwann Cells through a Specific Grb2-HER2(erbB2) Interaction.
Dev Neurosci. 23(1):25-30.
4. Krahn G et al., (2001) Coexpression patterns of EGFR, HER2, HER3 and HER4 in non-melanoma skin cancer. Eur J Cancer. 37(2):251-9
5. Garratt AN et al., (2000) Neuregulin, a factor with many functions in the life of a schwann cell. Bioessays. 22(11):987-96. Review.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ERBB3 / HER3 antibody

  Rabbit Monoclonal anti-c-erbB-3/HER-3 Antibody  
Human Small Intestine stained with anti-c-erbB-3_HER-3 antibody. Rabbit IgG SP71 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

ERBB3 / HER3 antibody

  Rabbit Polyclonal ErbB3 Antibody  
Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-ERBB3 Rabbit Polyclonal antibody. (TA590106) Rabbit IgG Purified Hu P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

ERBB3 / HER3 antibody

  ERBB3 mouse monoclonal antibody, clone OTI3E10 (formerly 3E10)  
Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-ERBB3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA803694) Mouse IgG2b OTI3E10 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

ERBB3 / HER3 antibody

  ERBB3 mouse monoclonal antibody, clone OTI3C1  
Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-ERBB3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA809228)(1:150) Mouse IgG1 OTI3C1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

ERBB3 / HER3 antibody

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 2E9 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

ERBB3 / HER3 pTyr1328 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Her3/ErbB3 pTyr1328 Antibody (#AP08032PU). Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

ERBB3 / HER3 pTyr1328 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Her3/ErbB3 pTyr1328 Antibody (#AP08032PU). Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
50 µl / €240.00
  Acris Antibodies GmbH

ERBB3 / HER3 antibody

Human colon carcinoma stained with anti-c-erbB3 antibody Rabbit Purified Hu P
1 ml / €530.00
  Acris Antibodies GmbH

ERBB3 / HER3 antibody

Human colon carcinoma stained with anti-c-erbB3 antibody Rabbit Purified Hu P

Regular Price: 0.2 ml / €200.00

Special Price: 0.2 ml / €140.00

  Acris Antibodies GmbH

ERBB3 / HER3 (Isoform 1) (C-term) antibody

  Goat Polyclonal Antibody against ERBB3  
TA303054 (0.1µg/ml) staining of Jurkat lysate (35µg protein in RIPA buffer) with (B) and without (A) blocking with the immunising peptide.  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ERBB3 / HER3 antibody

  Rabbit polyclonal anti-HER3 antibody  
Western blot analysis of extracts from COLO205 cells, using HER3 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ERBB3 / HER3 antibody

  Rabbit polyclonal anti-HER3 antibody  
CoIP and WB of a human cell lysate using anti-HER3 antibody. Lysates were prepared from a human LNCap prostate cell line both with (+) treatment with  Heregulin-b1 for 15' at 100 ng/ml and without (-) the addition of Heregulin-b1.  The combination of IP and WBting was performing using 5 µl of the anti-HER3 antibody for IP followed by WB detection using an anti-phosphotyrosine antibody. Visualization occurred using an ECL system.  Film exposure approximately 1’. Rabbit Purified Hu, Ms, Rt IP, WB
0.25 mg / €356.00
  OriGene Technologies, Inc.

ERBB3 / HER3 antibody

  Anti-ERBB3 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm, Cell membrane. Positive control: Human colon cancer tissue. Recommended dilution: 1/50-150  The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using ERBB3 antibody at dilution 1/35, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

ERBB3 / HER3 antibody

  Anti-ERBB3 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm . Positive control: Human colon cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using ERBB3 antibody at dilution 1/20, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

ERBB3 / HER3 antibody

  Anti-ERBB3 (phospho-Tyr1328) Rabbit Polyclonal Antibody  
Predicted band size: 148 kDa . Positive control: A431 cells treated with EGF lysate. Recommended dilution: 1/ 500-1000. (Gel: 8%SDS-PAGE Lane1: A431 cells untreated with EGF lysate Lane2: A431 cells treated with EGF lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ERBB3 / HER3 antibody

  Rabbit anti-ERBB3 Polyclonal Antibody  
Western blot analysis of extracts of A431 cell line, using ERBB3 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

ERBB3 / HER3 antibody

  Mouse monoclonal Anti-ErbB3 Clone RTJ1  
ERBB3 / HER3 Mouse IgG1 RTJ1 Purified Hu IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ERBB3 / HER3 antibody

  Mouse monoclonal Anti-ErbB3 Clone RTJ2  
ERBB3 / HER3 Mouse IgG1 RTJ2 Purified Hu E, F, ICC/IF, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ERBB3 / HER3 antibody

  Mouse monoclonal Anti-ErbB3 Clone SGP1  
ERBB3 / HER3 Mouse IgG2 SGP1 Purified Hu F, ICC/IF, IP, P
0.1 mg / €325.00
  OriGene Technologies, Inc.

ERBB3 / HER3 antibody

  Rabbit Polyclonal anti-c-erbB-3/HER-3 Antibody  
Human Colon Carcinoma stained with anti-c-erbB-3_HER-3 antibody. Rabbit IgG Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

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