ERI1 / THEX1 antibody

Principal name

ERI1 / THEX1 antibody

Alternative names for ERI1 / THEX1 antibody

3'-5' exoribonuclease 1, 3'EXO, HEXO, Histone mRNA 3'-exonuclease 1, Histone mRNA 3'-exonuclease 1, 3'-5' exonuclease ERI1, Eri-1 homolog, Histone mRNA 3'-end-specific exoribonuclease, Protein 3'hExo

SwissProt ID

Q5FVR4 (Rat), Q7TMF2 (Mouse), Q8IV48 (Human)

Gene ID

90459 (ERI1)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Mky (Monkey), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of ERI1 / THEX1 antibody

RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.

General readings

Rose, J. Phd, et al. Mol. Med. (2010) In press
Mullen, T.E., et al. Genes Dev. 22(1):50-65(2008)
Kupsco, J.M., et al. RNA 12(12):2103-2117(2006)
Yang, X.C., et al. J. Biol. Chem. 281(41):30447-30454(2006)
Cheng, Y., et al. J. Mol. Biol. 343(2):305-312(2004).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ERI1 / THEX1 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-ERI1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504134) Mouse IgG2b OTI1B3 Purified Hu, Mky, Rt P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

ERI1 / THEX1 antibody

Western blot analysis of rat brain lysate (Lanes 1 and 2: 84ug lysate) with anti-THEX1 antibody diluated at 1:1000. (Predicted and observed size: 40kDa) Rabbit IgG Purified Hu, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ERI1 / THEX1 antibody

Western blot analysis of extracts from COLO205 cells, using ERI1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ERI1 / THEX1 antibody

WB Suggested Anti-THEX1 Antibody Titration: 0.2-1 ug/ml; Positive Control: MCF7 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

ERI1 / THEX1 antibody

WB Suggested Anti-THEX1 Antibody Titration: 2.5 ug/ml; ELISA Titer: 1: 1562500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ERI1 / THEX1 (N-term) antibody

Western blot analysis of ERI1 / THEX1 (N-term) Antibody (N-term) Cat.-No AP51455PU-N in 293 cell line lysates (35ug/lane). This demonstrates the ERI1 antibody detected the ERI1 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

ERI1 / THEX1 antibody

Western Blot analysis of ERI1 expression in transfected 293T cell line (H00090459-T01) by ERI1 MaxPab polyclonal antibody.

Lane 1: THEX1 transfected lysate(38.39 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

ERI1 / THEX1 antibody

Human MCF-7; WB Suggested Anti-THEX1 Antibody Titration: 0.2-1 ug/ml. Positive Control: MCF7 cell lysate; THEX1 antibody - N-terminal region (ARP41157_P050) in Human MCF-7 cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

ERI1 / THEX1 antibody

Human HepG2; WB Suggested Anti-THEX1 Antibody Titration: 2.5ug/ml. ELISA Titer: 1:1562500. Positive Control: HepG2 cell lysate; THEX1 antibody - C-terminal region (ARP41158_T100) in Human HepG2 cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rt, Ze WB
0.1 mg / €310.00
  AVIVA Systems Biology

ERI1 / THEX1 antibody

Western Blot: HEXO Antibody [NBP1-57118] - This Anti-THEX1 antibody was used in Western Blot of MCF7 tissue lysate at a concentration of 0.5ug/ml. Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ERI1 / THEX1

ERI1 / THEX1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

ERI1 / THEX1

ERI1 / THEX1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

ERI1 / THEX1

ERI1 / THEX1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

THEX1 293T Cell Transient Overexpression Lysate(Denatured)

THEX1 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

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