ESM1 antibody

Principal name

ESM1 antibody

Alternative names for ESM1 antibody

Endothelial cell-specific molecule 1, Endocan

SwissProt ID

P97682 (Rat), Q9NQ30 (Human), Q9QYY7 (Mouse)

Gene ID

11082 (ESM1), 71690 (Esm1), 64536

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Mouse, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of ESM1 antibody

Endocan, also known as endothelial cell-specific molecule1 (ESM1), is a secreted cysteine-rich dermatan sulfate (DS) proteoglycan primarily expressed by endothelial cells within the vascular capillary network in kidney and in the alveolar walls of the lung. Endocan expression has also been detected in different epithelia and in adipocytes. The expression of endocan is up-regulated by TNFα, IL1β or lipopolysaccharide and down-regulated by IFNγ. The human Endocan gene encodes a 184 amino acid (aa) residues precursor protein with a 19 aa hydrophobic signal peptide and a 165 aa mature region with 18 Cysteine residues. The DS chain is covalently attached to serine 137. Endocan has been shown to bind CD11a/CD18 integrin (also known as lymphocyte function-associated antigen1, LFA1) on human lymphocytes, monocytes and Jurkat cells, inhibiting its binding to ICAM1 and reducing LFA1mediated leukocyte activation. Endocan binds via its DS chain to hepatocyte growth factor (HGF) to enhance HGF mitogenic activity. Genetically engineered cells overexpressing Endocan has been shown to induce tumor formation, suggesting that Endocan may be involved in the pathophysiology of tumor growth in vivo. Circulating Endocan can be detected in the serum from healthy subjects. In patients with lung cancer or acute and severe sepsis, elevated Endocan concentrations have been reported.

General readings

Scherpereel A., et al. (2003) Cancer Res. 63:6084.Bechard D., et al. (2000) J Vasc Res. 37:417.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ESM1 antibody

Immunofluorescence staining of cryosections of unfixed human foreskin with anti-human Endocan/EMS1 Cat.-No. AP60002PU-N (dilution 1/100) and counter staining of nuclei with DAPI.&amp;lt;br /&amp;gt;Note specific green Endocan/ESM1 signals in epidermis, connective tissue cells and vessels.<br /><em>The experiment was performed by the research group of Prof. Dr. J. Wilting and Dr. K. Buttler, University Medicine Göttingen, Germany.</em> Rabbit IgG Purified Hu C, ICC/IF, WB
0.2 mg / €370.00
  OriGene Technologies GmbH

ESM1 antibody

Immunofluorescence staining of cryosections of unfixed human foreskin with anti-human Endocan/EMS1 Cat.-No. AP60002PU-N (dilution 1/100) and counter staining of nuclei with DAPI.&amp;lt;br /&amp;gt;Note specific green Endocan/ESM1 signals in epidermis, connective tissue cells and vessels.<br /><em>The experiment was performed by the research group of Prof. Dr. J. Wilting and Dr. K. Buttler, University Medicine Göttingen, Germany.</em> Rabbit IgG Purified Hu C, ICC/IF, WB
0.1 mg / €270.00
  OriGene Technologies GmbH

2 Item(s)

per page
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