Estrogen receptor alpha antibody

Principal name

Estrogen receptor alpha antibody

Alternative names for Estrogen receptor alpha antibody

ER alpha, Estradiol receptor, ESR1, ESR, NR3A1, Nuclear receptor subfamily 3 group A member 1

SwissProt ID

P03372 (Human), P06211 (Rat), P06212 (Chick), P19785 (Mouse), P49884 (Bovin), P49885 (Sheep), P81559 (Xenla), Q29040 (Pig), Q53AD2 (Felca), Q9TV98 (Horse)

Gene ID

2099 (ESR1), 13982 (Esr1), 407238

Available reactivities

Hu (Human), Hst (Hamster), Ms (Mouse), Rt (Rat), Bov (Bovine), Mky (Monkey), Rb (Rabbit), Can (Canine), Gt (Goat), Por (Porcine), Sh (Sheep), Re (Reptiles), Chk (Chicken)

Available hosts

Mouse, Rabbit, Chicken

Available applications

Frozen Sections (C), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunoprecipitation (IP), PLA/Proximity ligation assay (PLA), Flow Cytometry (F), Electrophoretic Mobility Shift Assay (EMSA), Immunocytochemistry/Immunofluorescence (ICC/IF), Neutralisation (NEUT), Enzyme Immunoassay (E), ChIP assay (ChIP), ELISA (detection) (E(detection)), Dot blot (Dot), Luminex (LMNX)

Background of Estrogen receptor alpha antibody

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p5 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1.

General readings

This product has been used in:Shevde NK & Pike JW Estrogen modulates the recruitment of myelopoietic cell progenitors in rat through a stromal cell-independent mechanism involving apoptosis. Blood 87:2683-92 (1996). PubMed PMID: 8639884
Yang NN et al. Identification of an estrogen response element activated by metabolites of 17beta-estradiol and raloxifene. Science 273:1222-5 (1996). PubMed PMID: 8703055
Traish AM & Pavao M Binding of site-directed monoclonal antibodies to an epitope located in the A/B region (amino acids 140-154) of human estrogen receptor-induced conformational changes in an epitope in the DNA-binding domain. Steroids 61:549-56 (1996). PubMed PMID: 8883222
Ikegami A et al. Immunohistochemical detection and northern blot analysis of estrogen receptor in osteoblastic cells. J Bone Miner Res 8:1103-9 (1993). PubMed PMID: 8237480
Orimo A et al. Vascular smooth muscle cells as target for estrogen. Biochem Biophys Res Commun 195:730-6 (1993). PubMed PMID: 7690560
Traish AM et al. Development and characterization of monoclonal antibodies to a specific domain of human estrogen receptor. Steroids 55:196-208 (1990). PubMed PMID: 2360217

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Estrogen receptor antibody

Formalin-Fixed, Paraffin-Embedded Human breast invasive ductal carcinoma stained with Estrogen Receptor Antibody Cat.-No AM32843PU (Clone ER506). Mouse IgG1 ER506 Purified Hu C, F, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Estrogen receptor antibody

Formalin-Fixed, Paraffin-Embedded Human breast invasive ductal carcinoma stained with Estrogen Receptor Antibody Cat.-No AM32843PU (Clone ER506). Mouse IgG1 ER506 Purified Hu C, F, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Estrogen receptor antibody

Formalin-Fixed, Paraffin-Embedded Human breast invasive ductal carcinoma stained with Estrogen Receptor Antibody Cat.-No AM32843PU (Clone ER506). Mouse IgG1 ER506 Purified Hu C, F, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Estrogen receptor antibody

Formalin-Fixed, Paraffin-Embedded Human breast carcinoma stained with Estrogen receptor Antibody Cat.-No AM32845SU (Clone ERa078) at 1/200 dilution using peroxidase-conjugate and DAB chromogen. Mouse IgG1 ERa078 Supernatant Hu P
1.0 ml / €360.00
  Acris Antibodies GmbH

Estrogen receptor (aa 2-185) antibody

Formalin-Fixed, Paraffin-Embedded Human breast carcinoma stained with Estrogen receptor Antibody Cat.-No AM32845SU (Clone ERa078) at 1/200 dilution using peroxidase-conjugate and DAB chromogen. Mouse IgG1 ERa078 Supernatant Hu C, F, P, WB
0.5 ml / €290.00
  Acris Antibodies GmbH

Estrogen receptor antibody

Formalin-Fixed, Paraffin-Embedded Human breast carcinoma stained with Estrogen receptor Antibody Cat.-No AM32845SU (Clone ERa078) at 1/200 dilution using peroxidase-conjugate and DAB chromogen. Mouse IgG1 ERa078 Supernatant Hu P
0.1 ml / €150.00
  Acris Antibodies GmbH

Estrogen receptor (alpha + beta) antibody

Estrogen receptor Rabbit IgG H17-A FITC Hu F
100 Tests / €640.00
  DB Biotech, spol. s r.o.

Sample sizes available

Estrogen receptor alpha antibody

Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-ESR1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503759) Mouse IgG2b OTI1B1 Purified Hu P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Estrogen receptor alpha antibody

Estrogen receptor alpha Mouse IgG1 6F11 Supernatant Hu C, P, WB
1 ml / €990.00
  Acris Antibodies GmbH

Estrogen receptor alpha antibody

Estrogen receptor alpha Mouse IgG1 6F11 Supernatant Hu C, IP, P, WB
0.5 ml / €660.00
  Acris Antibodies GmbH

Estrogen receptor alpha antibody

Estrogen receptor alpha Mouse IgG1 6F11 Supernatant Hu C, P
0.1 ml / €240.00
  Acris Antibodies GmbH

Estrogen receptor alpha antibody

Immunohistochemical staining of paraffin-embedded Human breast tissue using anti-ESR1 mouse monoclonal antibody. (TA804039) Mouse IgG1 OTI2D3 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Estrogen receptor alpha antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-ESR1 mouse monoclonal antibody. (TA804315) Mouse IgG2b OTI8E9 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Estrogen receptor alpha antibody

Immunohistochemical staining of paraffin-embedded Human Ovary tissue using anti-ESR1 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA804480)(1:150) Mouse IgG2b OTI9E6 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Estrogen receptor alpha antibody

Immunohistochemical staining of paraffin-embedded Human endometrium tissue using anti-ESR1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA807239)(1:1200) Mouse IgG2a OTI3G2 Purified Can, Hu, Mky, Ms P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Estrogen receptor alpha antibody

Immunohistochemical staining of paraffin-embedded Human endometrium tissue using anti-ESR1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA809106)(1:150) Mouse IgG2a OTI5E11 Purified Can, Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Estrogen receptor alpha pSer118 antibody

Western blot analysis of extracts from COS7 cells, treated with starve or calf intestinal phosphatase (CIP) using Estrogen Receptor-alpha (pSer118) Antibody Rabbit Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

Estrogen receptor alpha pSer118 antibody

Western blot analysis of extracts from COS7 cells, treated with starve or calf intestinal phosphatase (CIP) using Estrogen Receptor-alpha (pSer118) Antibody Rabbit Aff - Purified Hu ICC/IF, P, WB
50 µl / €240.00
  Acris Antibodies GmbH

Estrogen receptor alpha (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human breast tumor tissue (4 µm) stained with anti-ER antibody (DB 053) shows strong positive nuclear  immunostaining. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG S21-V Aff - Purified Hu P
0.1 ml / €310.00
  DB Biotech, spol. s r.o.

Sample sizes available

Estrogen receptor alpha (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human breast tumor tissue (4 µm) stained with anti-ER antibody (DB 053) shows strong positive nuclear  immunostaining. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG S21-V Aff - Purified Hu P
0.2 ml / €420.00
  DB Biotech, spol. s r.o.

Sample sizes available

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