Estrogen receptor alpha antibody

Principal name

Estrogen receptor alpha antibody

Alternative names for Estrogen receptor alpha antibody

ER alpha, Estradiol receptor, ESR1, ESR, NR3A1, Nuclear receptor subfamily 3 group A member 1

SwissProt ID

P03372 (Human), P06211 (Rat), P06212 (Chick), P19785 (Mouse), P49884 (Bovin), P49885 (Sheep), P81559 (Xenla), Q29040 (Pig), Q53AD2 (Felca), Q9TV98 (Horse)

Gene ID

2099 (ESR1), 407238, 13982 (Esr1), 24890

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Hst (Hamster), Bov (Bovine), Can (Canine), Por (Porcine), Rb (Rabbit), Re (Reptiles), Chk (Chicken), Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), ELISA (detection) (E(detection)), ChIP assay (ChIP), Immunoprecipitation (IP), Flow Cytometry (F), Luminex (LMNX)

Background of Estrogen receptor alpha antibody

The estrogen receptor (ER) is a ~ 67kDa protein, originally described by Jensen and Jacobson, 1962 as a uterine protein which bound 3H-estradiol with high affinity. More than two decades later the cDNA encoding the human estrogen receptor was finally cloned and sequenced. The estrogen receptor gene consists of more than 140kb of genomic DNA divided into 8 exons, being translated into a protein with six functionally discrete domains, labeled A through F. The A/B domain of the estrogen receptor contains a constitutively active transcription activation function called TAF-1. Domain C contains two Cys4 zinc fingers, which form the core of the DNA binding domain; it also contains a weak constitutive dimerization activity. The zinc fingers interact with DNA, and the ER homodimer appears to bind most tightly to the palindromic estrogen response element (ERE) sequence GGATCNNNGATCC. The hinge domain D appears to be the location for binding by heat shock proteins. The estrogen receptor is an important regulator of growth and differentiation in the mammary gland. Estrogens play an important role also in breast cancer development, although tumors often progress towards an autocrine growth. This hormone-independence and the incomplete correlation between ER-status and response to endocrine (tamoxifen) therapy may be explained by the presence of receptor variants with either constitutive transcriptional activity or a dominant negative inhibition of normal ER function. Many investigators have reported on the isolation of cDNAs which encode variant ER sequences. Many of these variants appear to be formed by errors in RNA splicing which result in one or more exons being lost during processing of the ER message.

General readings

Geradts, J., et al. Cancer Invest. 28(9):969-977(2010)
Hayes, D.F., et al. Clin. Pharmacol. Ther. 88(5):626-629(2010)
Lupien, M., et al. Genes Dev. 24(19):2219-2227(2010)
Corbo, R.M., et al. J. Gerontol. A Biol. Sci. Med. Sci. (2010) In press
Kim, S., et al. Fertil. Steril. (2010) In press.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Estrogen receptor antibody

Intracellular staining of the Human breast cancer line MCF7 using Estrogen Receptor Antibody Cat.-No AM32843PU (Clone ER506). Paraformaldehyde and 0.1% Tween-PBS were used to fix/perm the cells. Mouse IgG1 ER506 Purified Hu C, F, P, WB
0.2 mg / €410.00
  Acris Antibodies GmbH

Estrogen receptor antibody

Intracellular staining of the Human breast cancer line MCF7 using Estrogen Receptor Antibody Cat.-No AM32843PU (Clone ER506). Paraformaldehyde and 0.1% Tween-PBS were used to fix/perm the cells. Mouse IgG1 ER506 Purified Hu C, F, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Estrogen receptor antibody

Intracellular staining of the Human breast cancer line MCF7 using Estrogen Receptor Antibody Cat.-No AM32843PU (Clone ER506). Paraformaldehyde and 0.1% Tween-PBS were used to fix/perm the cells. Mouse IgG1 ER506 Purified Hu C, F, P, WB
20 µg / €180.00
  Acris Antibodies GmbH

Estrogen receptor (alpha + beta) antibody

Estrogen receptor Rabbit IgG H17-A FITC Hu F
100 Tests / €640.00
  DB Biotech, spol. s r.o.

Sample sizes available

Estrogen receptor alpha antibody

  ESR1 (Estrogen Receptor 1/ER) mouse monoclonal antibody, clone OTI1B1 (formerly 1B1)  
Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-ESR1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503759) Mouse IgG2b OTI1B1 Purified Hu P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Estrogen receptor alpha antibody

Estrogen receptor alpha Mouse IgG1 6F11 Supernatant Hu C, P, WB
1 ml / €990.00
  Acris Antibodies GmbH

Estrogen receptor alpha antibody

Estrogen receptor alpha Mouse IgG1 6F11 Supernatant Hu C, IP, P, WB
0.5 ml / €680.00
  Acris Antibodies GmbH

Estrogen receptor alpha antibody

Estrogen receptor alpha Mouse IgG1 6F11 Supernatant Hu C, P
0.1 ml / €240.00
  Acris Antibodies GmbH

Estrogen receptor alpha antibody

  Rabbit Monoclonal anti-Estrogen Receptor (ER) Antibody  
Western Blot analysis of MCF7 cell lysate with ER antibody Rabbit IgG SP1 Purified Hu P, WB
0.1 ml / €400.00
  OriGene Technologies, Inc.

Estrogen receptor alpha antibody

  ESR1 mouse monoclonal antibody, clone OTI2D3 (formerly 2D3)  
Immunohistochemical staining of paraffin-embedded Human breast tissue using anti-ESR1 mouse monoclonal antibody. (TA804039) Mouse IgG1 OTI2D3 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Estrogen receptor alpha antibody

  ESR1 mouse monoclonal antibody, clone OTI8E9 (formerly 8E9)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-ESR1 mouse monoclonal antibody. (TA804315) Mouse IgG2b OTI8E9 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Estrogen receptor alpha antibody

  ESR1 mouse monoclonal antibody, clone OTI9E6 (formerly 9E6)  
Immunohistochemical staining of paraffin-embedded Human Ovary tissue using anti-ESR1 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA804480)(1:150) Mouse IgG2b OTI9E6 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Estrogen receptor alpha antibody

  ESR1 mouse monoclonal antibody, clone OTI3G2 (formerly 3G2)  
Immunohistochemical staining of paraffin-embedded Human endometrium tissue using anti-ESR1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA807239)(1:1200) Mouse IgG2a OTI3G2 Purified Can, Hu, Mky, Ms P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Estrogen receptor alpha antibody

  ESR1 mouse monoclonal antibody, clone OTI5E11 (formerly 5E11)  
Immunohistochemical staining of paraffin-embedded Human endometrium tissue using anti-ESR1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA809106)(1:150) Mouse IgG2a OTI5E11 Purified Can, Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Estrogen receptor alpha pSer118 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Estrogen Receptor-alpha (pSer118) antibody (left) or the same antibody preincubated with blocking peptide (right) Rabbit Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

Estrogen receptor alpha pSer118 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Estrogen Receptor-alpha (pSer118) antibody (left) or the same antibody preincubated with blocking peptide (right) Rabbit Aff - Purified Hu ICC/IF, P, WB
50 µl / €240.00
  Acris Antibodies GmbH

Estrogen receptor alpha (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human breast tumor tissue (4 µm) stained with anti-ER antibody (DB 053) shows strong positive nuclear  immunostaining. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG S21-V Aff - Purified Hu P
0.1 ml / €310.00
  DB Biotech, spol. s r.o.

Sample sizes available

Estrogen receptor alpha (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human breast tumor tissue (4 µm) stained with anti-ER antibody (DB 053) shows strong positive nuclear  immunostaining. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG S21-V Aff - Purified Hu P
0.2 ml / €420.00
  DB Biotech, spol. s r.o.

Sample sizes available

Estrogen receptor alpha (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human breast tumor tissue (4 µm) stained with anti-ER antibody (DB 053) shows strong positive nuclear  immunostaining. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG S21-V Aff - Purified Hu P
0.5 ml / €530.00
  DB Biotech, spol. s r.o.

Sample sizes available

Estrogen receptor alpha (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human breast tumor tissue (4 µm) stained with anti-ER antibody (DB 053) shows strong positive nuclear  immunostaining. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG S21-V Aff - Purified Hu P
1 ml / €820.00
  DB Biotech, spol. s r.o.

Sample sizes available

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