Estrogen receptor beta antibody

Principal name

Estrogen receptor beta antibody

Alternative names for Estrogen receptor beta antibody

ER-beta,ESR2, ESTRB, NR3A2, Nuclear receptor subfamily 3 group A member 2

SwissProt ID

O08537 (Mouse), Q62986 (Rat), Q92731 (Human), Q9PTU5 (Chick), Q9TU15 (Sheep), Q9XSB5 (Bovin), Q9XSW2 (Pig)

Gene ID

2100 (ESR2), 25149 (Esr2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Prim (Primate), Sh (Sheep), Bov (Bovine), Can (Canine), Por (Porcine), Marmoset, Mky (Monkey), Ll (Llama), Eq (Equine), Chk (Chicken)

Available hosts

Rabbit, Mouse, Goat

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Electrophoretic Mobility Shift Assay (EMSA), Flow Cytometry (F), Immunoprecipitation (IP), ChIP assay (ChIP), Enzyme Immunoassay (E), ELISA (detection) (E(detection))

Background of Estrogen receptor beta antibody

Estrogen, a steroid hormone, is a key regulator of growth and differentiation in a broad range of target tissues and, it is also implicated in breast and endometrial cancer and osteoporosis (1). Like all steroid hormones, estrogen readily diffuses across cell membrane and binds to and activates estrogen receptors (α and β) which then up-regulate the expression of many genes. These receptors belong to the superfamily of nuclear receptors, more specifically to the family of steroid receptors that act as ligand-regulated transcription factors (2). Estrogen binding receptor protein was first discovered in the early sixties, followed by cloning of this receptor in the mid-eighties. In 996, this receptor was renamed estrogen receptor alpha (ER-alpha) due to cloning of an additional estrogen receptor from rat prostrate. This novel receptor was designated estrogen receptor beta (ER-beta) (3). ER-beta is located on mouse chromosome 12 D1-D3. Recent reports have shown that ER-beta is important for the prevention of age-related hearing loss, proper cAMP signaling pathway, polyovular follicles in mouse ovaries and also important in regulating tyrosine hydroxylase expression in the moue locus coeruleus (4).
Any disruption in estrogen receptor beta signaling has been shown to cause negative effects on ovulation and fertility (4). ER-beta deficiency in mice was found to be associated with increase in small intestine tumorigenesis. ER-beta deficiency also leads to increase epithelial proliferation, decreased apoptosis, and accumulation of incompletely differentiated cells in mouse ventral prostrates (5). In male mice, ER-beta deletion affected the structure of their arteries. ER-beta is expressed in kidney, spleen, testis and skeletal muscles. It is approximately a 72kDa protein (567 amino acids).

General readings

This product has been used in:Rosenfeld CS et al. Cloning, sequencing, and localization of bovine estrogen receptor-beta within the ovarian follicle. Biol Reprod 60:691-7 (1999). PubMed PMID: 10026117
Rosenfeld CS et al. Transcription and translation of estrogen receptor-beta in the male reproductive tract of estrogen receptor-alpha knock-out and wild-type mice. Endocrinology 139:2982-7 (1998). PubMed PMID: 9607809
General / background references:Makela S et al. Differentiation between vasculoprotective and uterotrophic effects of ligands with different binding affinities to estrogen receptors alpha and beta. Proc Natl Acad Sci U S A 96:7077-82 (1999). PubMed PMID: 10359841
Alves SE et al. Differential colocalization of estrogen receptor beta (ERbeta) with oxytocin and vasopressin in the paraventricular and supraoptic nuclei of the female rat brain: an immunocytochemical study. Proc Natl Acad Sci U S A 95:3281-6 (1998). PubMed PMID: 9501254
Krege JH et al. Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proc Natl Acad Sci U S A 95:15677-82 (1998). PubMed PMID: 9861029
Petersen DN et al. Identification of estrogen receptor beta2, a functional variant of estrogen receptor beta expressed in normal rat tissues. Endocrinology 139:1082-92 (1998). PubMed PMID: 9492041
Li X et al. Distribution of estrogen receptor-beta-like immunoreactivity in rat forebrain. Neuroendocrinology 66:63-7 (1997). PubMed PMID: 9263202

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Estrogen receptor beta (Isoform 1) (C-term) antibody

Photomicrograph of human ovary immunostained for estrogen receptor beta using monoclonal antibody Cat.-No SM1682 (Clone PPG5/10). Mouse IgG2a PPG5/10 Supernatant Hu, Ll, Marmoset, Mky, Por, Prim, Rt, Sh C, ICC/IF, P
2 ml / €940.00
  Acris Antibodies GmbH

Estrogen receptor beta (Isoform 1) (C-term), 10 x conc. antibody

Staining of formalin fixed, paraffin embedded Human Placenta with Mouse anti Human estrogen Receptor (Cat.-No SM1682 Clone PPG5/10). Mouse IgG2a PPG5/10 Supernatant Hu C, ICC/IF, P
1 ml / €880.00
  Acris Antibodies GmbH

Estrogen receptor beta antibody

Hum. Adult Placenta; Host: Rabbit. Target Name: CHAD . Sample Tissue: Human Adult Placenta . Antibody Dilution: 1.0ug/ml.; ESR2 antibody - middle region (ARP32258_P050) in Hum. Adult Placenta cells using Western Blot Rabbit Aff - Purified Bov, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Estrogen receptor beta (C-term) antibody

Formalin-Fixed, Paraffin-Embedded ovarian cancer stained with Estrogen receptor beta Antibody Cat.-No AM32846PU (Clone ERb455). Mouse IgG1 ERb455 Purified Eq, Hu, Mky, Ms, Por, Rt, Sh C, E, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Estrogen receptor beta (C-term) antibody

Formalin-Fixed, Paraffin-Embedded ovarian cancer stained with Estrogen receptor beta Antibody Cat.-No AM32846PU (Clone ERb455). Mouse IgG1 ERb455 Purified Hu, Mky, Ms, Por, Rt, Sh C, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Estrogen receptor beta (C-term) antibody

Formalin-Fixed, Paraffin-Embedded ovarian cancer stained with Estrogen receptor beta Antibody Cat.-No AM32846PU (Clone ERb455). Mouse IgG1 ERb455 Purified Hu, Mky, Ms, Por, Rt, Sh C, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Estrogen receptor beta (417-428) antibody

(1ug/ml) staining of Human Placenta lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Estrogen receptor beta antibody

ESR2 Antibody (Center) (Cat. #TA324615) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the ESR2 antibody detected the ESR2 protein (arrow). Rabbit IgG Purified Bov, Chk, Hu, Por, Rt F, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Estrogen receptor beta antibody

ESR2 Antibody (C-term) (Cat. #TA324671) western blot analysis in MCF-7 cell line and human placenta tissue lysates (35ug/lane).This demonstrates the ESR2 antibody detected the ESR2 protein (arrow). Rabbit IgG Purified Bov, Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Estrogen receptor beta antibody

ESR2 Antibody (C-term) (Cat. #TA324672) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the ESR2 antibody detected the ESR2 protein (arrow). Rabbit IgG Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Estrogen receptor beta antibody

Western blot analysis of Estrogen Receptor- beta phosphorylation expression in HepG2 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Estrogen receptor beta antibody

Western blot analysis of Estrogen Receptor-beta expression in EGF treated HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Estrogen receptor beta antibody

Western blot analysis of extracts of various cell lines, using ESR2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Estrogen receptor beta antibody

ELISA: Estrogen Receptor beta Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

Estrogen receptor beta (F region) antibody

Cat.-No. AM21050PU-N (Clone 4ERbeta-2D7) ESTRB antibody staining of Human Hypothalamus Paraffin Section. Mouse IgG1 ERbeta-2D7 Aff - Purified Hu, Ms C, P
0.25 mg / €400.00
  Acris Antibodies GmbH

Estrogen receptor beta antibody

Western blot (WB) analysis of ER-beta antibody (Cat.-No.: AP06806PU-N) in extracts from HeLa cells. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Estrogen receptor beta control peptide

Estrogen receptor beta
0.25 mg / €250.00
  Acris Antibodies GmbH

Estrogen receptor beta (Isoform 1) antibody

Western Blot of Estrb-1. Estrb-1 antibody (Cat#AP09861PU-N) at 1/500 dilution. Rabbit Aff - Purified Ms, Rt E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Estrogen receptor beta (230-241) antibody

Prostate, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Aff - Purified Bear, Bov, Bt, Can, GP, Hu, Mky, Ms, Prim, Sh P
50 µg / €470.00
  Acris Antibodies GmbH

Estrogen receptor beta (N-term) antibody

Estrogen receptor beta Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €340.00
  Acris Antibodies GmbH

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