Estrogen receptor beta antibody

Principal name

Estrogen receptor beta antibody

Alternative names for Estrogen receptor beta antibody

ER-beta,ESR2, ESTRB, NR3A2, Nuclear receptor subfamily 3 group A member 2

SwissProt ID

O08537 (Mouse), Q62986 (Rat), Q92731 (Human), Q9PTU5 (Chick), Q9TU15 (Sheep), Q9XSB5 (Bovin), Q9XSW2 (Pig)

Gene ID

2100 (ESR2), 13983 (Esr2)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), Marmoset, Mky (Monkey), Prim (Primate), Sh (Sheep), Ll (Llama), Bt (Bat), GP (Guinea Pig), Bear, Eq (Equine), Chk (Chicken)

Available hosts

Rabbit, Mouse, Goat, Rat

Available applications

Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Flow Cytometry (F)

Background of Estrogen receptor beta antibody

Estrogen, a steroid hormone, is a key regulator of growth and differentiation in a broad range of target tissues and, it is also implicated in breast and endometrial cancer and osteoporosis (1). Like all steroid hormones, estrogen readily diffuses across cell membrane and binds to and activates estrogen receptors (α and β) which then up-regulate the expression of many genes. These receptors belong to the superfamily of nuclear receptors, more specifically to the family of steroid receptors that act as ligand-regulated transcription factors (2). Estrogen binding receptor protein was first discovered in the early sixties, followed by cloning of this receptor in the mid-eighties. In 996, this receptor was renamed estrogen receptor alpha (ER-alpha) due to cloning of an additional estrogen receptor from rat prostrate. This novel receptor was designated estrogen receptor beta (ER-beta) (3). ER-beta is located on mouse chromosome 12 D1-D3. Recent reports have shown that ER-beta is important for the prevention of age-related hearing loss, proper cAMP signaling pathway, polyovular follicles in mouse ovaries and also important in regulating tyrosine hydroxylase expression in the moue locus coeruleus (4).
Any disruption in estrogen receptor beta signaling has been shown to cause negative effects on ovulation and fertility (4). ER-beta deficiency in mice was found to be associated with increase in small intestine tumorigenesis. ER-beta deficiency also leads to increase epithelial proliferation, decreased apoptosis, and accumulation of incompletely differentiated cells in mouse ventral prostrates (5). In male mice, ER-beta deletion affected the structure of their arteries. ER-beta is expressed in kidney, spleen, testis and skeletal muscles. It is approximately a 72kDa protein (567 amino acids).

General readings

Brandenberger,A.W., et al., (1997) J. Clin. Endocrinol. Metab. 82 (10), 3509-3512

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Estrogen receptor beta (Isoform 1) (C-term) antibody

Photomicrograph of human ovary immunostained for estrogen receptor beta using monoclonal antibody Cat.-No SM1682 (Clone PPG5/10). Mouse IgG2a PPG5/10 Supernatant Hu, Ll, Marmoset, Mky, Por, Prim, Rt, Sh C, ICC/IF, P
2 ml / €940.00
  Acris Antibodies GmbH

Estrogen receptor beta (Isoform 1) (C-term), 10 x conc. antibody

Staining of formalin fixed, paraffin embedded Human Placenta with Mouse anti Human estrogen Receptor (Cat.-No SM1682 Clone PPG5/10). Mouse IgG2a PPG5/10 Supernatant Hu C, ICC/IF, P
1 ml / €880.00
  Acris Antibodies GmbH

Estrogen receptor beta antibody

  Rabbit anti-ESR2 (Estrogen Receptor-beta, Phospho-Ser118) polyclonal antibody (Phospho-specific)  
Western blot analysis of extracts from MCF7 cells using Estrogen Receptor-alpha (phospho-Ser118) antibody. Rabbit IgG Purified Ms P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Estrogen receptor beta antibody

  Rabbit anti-ESR2 (Estrogen Receptor-beta, Phospho-Ser167) polyclonal antibody (Phospho-specific)  
Western blot analysis of extracts from MCF7 cells using Estrogen Receptor-alpha (phospho-Ser167) antibody. Rabbit IgG Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Estrogen receptor beta (417-428) antibody

  Goat Anti-Estrogen receptor beta (aa417-428) Antibody  
(1ug/ml) staining of Human Placenta lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Estrogen receptor beta antibody

  Rabbit polyclonal ESR2 Antibody (Center)  
ESR2 Antibody (Center) (Cat. #TA324615) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the ESR2 antibody detected the ESR2 protein (arrow). Rabbit IgG Purified Bov, Chk, Hu, Por, Rt F, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Estrogen receptor beta antibody

  Rabbit polyclonal ESR2 Antibody(C-term)  
ESR2 Antibody (C-term) (Cat. #TA324671) western blot analysis in MCF-7 cell line and human placenta tissue lysates (35ug/lane).This demonstrates the ESR2 antibody detected the ESR2 protein (arrow). Rabbit IgG Purified Bov, Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Estrogen receptor beta antibody

  Rabbit polyclonal ESR2 Antibody(C-term)  
ESR2 Antibody (C-term) (Cat. #TA324672) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the ESR2 antibody detected the ESR2 protein (arrow). Rabbit IgG Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Estrogen receptor beta antibody

  Rabbit Polyclonal Phospho-Estrogen Receptor- beta (Ser105) Antibody (Phospho-specific)  
Western blot analysis of Estrogen Receptor- beta phosphorylation expression in HepG2 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Estrogen receptor beta antibody

  Rabbit Polyclonal Estrogen Receptor-beta Antibody  
Western blot analysis of Estrogen Receptor-beta expression in EGF treated HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Estrogen receptor beta antibody

  Rabbit anti-ESR2 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using ESR2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Estrogen receptor beta antibody

  Rabbit Polyclonal Anti-ESR2 Antibody  
Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane: Mouse brain tissue, Primary antibody: (ESR2 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Estrogen receptor beta antibody

  Rat Monoclonal anti-Estrogen Receptor Antibody  
Estrogen receptor beta Rat D75 Purified Hu P
1 ml / €479.00
  OriGene Technologies, Inc.

Estrogen receptor beta antibody

  Mouse Monoclonal anti-Estrogen Receptor Antibody  
Estrogen receptor beta Mouse IgG2a CO1531 Purified Hu P
1 ml / €479.00
  OriGene Technologies, Inc.

Estrogen receptor beta antibody

  Rabbit Polyclonal Estrogen Receptor beta Antibody  
ELISA: Estrogen Receptor beta Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

Estrogen receptor beta (F region) antibody

Cat.-No. AM21050PU-N (Clone 4ERbeta-2D7) ESTRB antibody staining of Human Hypothalamus Paraffin Section. Mouse IgG1 ERbeta-2D7 Aff - Purified Hu, Ms C, P
0.25 mg / €400.00
  Acris Antibodies GmbH

Estrogen receptor beta antibody

Western blot (WB) analysis of ER-beta antibody (Cat.-No.: AP06806PU-N) in extracts from HeLa cells. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Estrogen receptor beta (230-241) antibody

Prostate, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Aff - Purified Bear, Bov, Bt, Can, GP, Hu, Mky, Ms, Prim, Sh P
50 µg / €470.00
  Acris Antibodies GmbH

Estrogen receptor beta (N-term) antibody

Estrogen receptor beta Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Estrogen receptor beta pSer105 antibody

Western blot analysis of extracts from HepG2 tissue using Estrogen Receptor- beta (Phospho-Ser105) antibody AP55945PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €340.00
  Acris Antibodies GmbH

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