Estrogen receptor beta antibody

Principal name

Estrogen receptor beta antibody

Alternative names for Estrogen receptor beta antibody

ER-beta,ESR2, ESTRB, NR3A2, Nuclear receptor subfamily 3 group A member 2

SwissProt ID

O08537 (Mouse), Q62986 (Rat), Q92731 (Human), Q9PTU5 (Chick), Q9TU15 (Sheep), Q9XSB5 (Bovin), Q9XSW2 (Pig)

Gene ID

2100 (ESR2), 13983 (Esr2)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), Marmoset, Mky (Monkey), Prim (Primate), Sh (Sheep), Ll (Llama), Bt (Bat), GP (Guinea Pig), Bear, Eq (Equine), Chk (Chicken)

Available hosts

Rabbit, Mouse, Goat, Rat

Available applications

Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Flow Cytometry (F)

Background of Estrogen receptor beta antibody

Estrogen, a steroid hormone, is a key regulator of growth and differentiation in a broad range of target tissues and, it is also implicated in breast and endometrial cancer and osteoporosis (1). Like all steroid hormones, estrogen readily diffuses across cell membrane and binds to and activates estrogen receptors (α and β) which then up-regulate the expression of many genes. These receptors belong to the superfamily of nuclear receptors, more specifically to the family of steroid receptors that act as ligand-regulated transcription factors (2). Estrogen binding receptor protein was first discovered in the early sixties, followed by cloning of this receptor in the mid-eighties. In 996, this receptor was renamed estrogen receptor alpha (ER-alpha) due to cloning of an additional estrogen receptor from rat prostrate. This novel receptor was designated estrogen receptor beta (ER-beta) (3). ER-beta is located on mouse chromosome 12 D1-D3. Recent reports have shown that ER-beta is important for the prevention of age-related hearing loss, proper cAMP signaling pathway, polyovular follicles in mouse ovaries and also important in regulating tyrosine hydroxylase expression in the moue locus coeruleus (4).
Any disruption in estrogen receptor beta signaling has been shown to cause negative effects on ovulation and fertility (4). ER-beta deficiency in mice was found to be associated with increase in small intestine tumorigenesis. ER-beta deficiency also leads to increase epithelial proliferation, decreased apoptosis, and accumulation of incompletely differentiated cells in mouse ventral prostrates (5). In male mice, ER-beta deletion affected the structure of their arteries. ER-beta is expressed in kidney, spleen, testis and skeletal muscles. It is approximately a 72kDa protein (567 amino acids).

General readings

Brandenberger,A.W., et al., (1997) J. Clin. Endocrinol. Metab. 82 (10), 3509-3512

1 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Estrogen receptor beta (F region) antibody

Cat.-No. AM21050PU-N (Clone 4ERbeta-2D7) ESTRB antibody staining of Human Hypothalamus Paraffin Section. Mouse IgG1 ERbeta-2D7 Aff - Purified Hu, Ms C, P
0.25 mg / €440.00
  OriGene Technologies GmbH

1 Item(s)

per page
  • LinkedIn