Estrogen-related receptor alpha antibody

Principal name

Estrogen-related receptor alpha antibody

Alternative names for Estrogen-related receptor alpha antibody

ESRRA, ERR1, ESRL1, NR3B1, Estrogen receptor-like 1, Steroid hormone receptor ERR1, Nuclear receptor subfamily 3 group B member 1

SwissProt ID

O08580 (Mouse), P11474 (Human), Q5QJV7 (Rat), Q6QMY5 (Canfa)

Gene ID

2101 (ESRRA), 26379 (Esrra)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Por (Porcine), Bov (Bovine), Eq (Equine), GP (Guinea Pig), Ye (Yeast)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Flow Cytometry (F), Electrophoretic Mobility Shift Assay (EMSA), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Estrogen-related receptor alpha antibody

Estrogen-related receptor alpha (ERR alpha), a NR3 Steroid Receptor, was isolated based on sequence similarity in its DNA-binding domain to estrogen receptor alpha (ER alpha). ERR alpha has been shown to regulate the promoters of lactoferrin, medium-chain acyl CoA dehydrogenase, osteopontin, and thyroid receptor alpha, and it may affect cellular energy balance and bone formation. ERR alpha binds as a monodimer to the extended half-site TNAAGGTCA and as a homodimer to the estrogen response element (ERE) and is a constitutive activator of the estrogen response element and the palindromic thyroid hormone response element (TRE(pal)) but not of the glucocorticoid response element (GRE). ERR alpha 1 is the major isoform expressed in human breast cancer cell lines. Recent studies have shown that Phe-329 is responsible for the constitutive activity of ERR alpha. ERR alpha is a potential biomarker for unfavorable clinical outcome and, possibly, hormonal insensitivity in breast tumors. ERR alpha status may be predictive of sensitivity to hormonal blockade therapy, and ERR alpha status may also be predictive of ErbB2-based therapy such as Herceptin. Moreover, ERR alpha may be a candidate target for therapeutic development. ERRalpha null mice have altered regulation of genes involved in adipogenesis.In mouse, ERR alpha is expressed in many adult and embryonic tissues (particularly at the onset of ossification) as well as in several osteoblast cell lines. ERR alpha expression has been documented in mouse in brain, spinal cord, pituitary gland, heart, intestine, bone, brown adipose tissue, heart, uterus, cervix, nerve, skeletal muscle, and vagina. ESTs have been isolated from human tissue libraries, including cancerous blood, brain, breast, cervix, colon, duodenum, eye, head/neck, kidney, liver, lung, ovary, pancreas, skeletal muscle, skin, stomach, and uterus, and normal adrenal, blood, brain, colon, embryo, eye, head/neck, heart, kidney, prostate, skeletal muscle, testis, and uterus. The ligands for ERR alpha are PPARgamma coactivator 1 (PGC-1) beta and flavone and isoflavone phytoestrogens.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Estrogen-related receptor alpha antibody

Anti-ESRRA antibody IHC of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Ms, Rt P
50 µg / €379.00
  OriGene Technologies, Inc.

Estrogen-related receptor alpha (Center) antibody

Flow cytometric analysis of 293 cells using ESRRA Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Rabbit Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Estrogen-related receptor alpha antibody

Western Blot: Estrogen Related Receptor alpha Antibody [TA336767] - Analysis of ERR alpha in A431 cell lysates Rabbit Purified Hu, Ms C, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Estrogen-related receptor alpha antibody

WB Suggested Anti-Esrra Antibody; Titration: 1.0 ug/ml; Positive Control: Mouse liver Rabbit IgG Purified Ms WB
50 µg / €325.00
  OriGene Technologies, Inc.

Estrogen-related receptor alpha antibody

WB Suggested Anti-ESRRA Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Transfected 293T Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rt, Ye WB
50 µg / €325.00
  OriGene Technologies, Inc.

Estrogen-related receptor alpha antibody

Anti-ESRRA antibody IHC of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Ms, Rt P
50 µg / €379.00
  OriGene Technologies, Inc.

Estrogen-related receptor alpha antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ESRRA (RC209028, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ESRRA.(1:2000) Mouse IgG1 OTI9D10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Estrogen-related receptor alpha antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ESRRA (RC209028, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ESRRA.(1:500) Mouse IgG2a OTI1E6 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Estrogen-related receptor alpha antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-ESRRA mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120 oC for 3 min, TA808637)(1:150) Mouse IgG1 OTI2C12 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Estrogen-related receptor alpha antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ESRRA (RC209028, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ESRRA.(1:2000) Mouse IgG1 OTI2C10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Estrogen-related receptor alpha antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ESRRA (RC209028, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ESRRA.(1:2000) Mouse IgG1 OTI1C6 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Estrogen-related receptor alpha antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ESRRA (RC209028, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ESRRA.(1:2000) Mouse IgG1 OTI3G10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Estrogen-related receptor alpha antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ESRRA (RC209028, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ESRRA.(1:2000) Mouse IgG1 OTI2G5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Estrogen-related receptor alpha antibody

ESRRA polyclonal antibody (A01), Lot # ABNOVA060619QCS1 Western Blot analysis of ESRRA expression in U-2 OS ( Cat # L022V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Estrogen-related receptor alpha antibody

Western Blot analysis of ESRRA expression in transfected 293T cell line (H00002101-T01) by ESRRA MaxPab polyclonal antibody.

Lane 1: ESRRA transfected lysate(46.53 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

Estrogen-related receptor alpha antibody

Immunoprecipitation of ESRRA transfected lysate using anti-ESRRA MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with ESRRA MaxPab mouse polyclonal antibody (B01) (H00002101-B01). Rabbit Serum Hu E(detection), IP
0.1 ml / €380.00
  Abnova Taiwan Corp.

Estrogen-related receptor alpha antibody

Western Blot analysis of ESRRA expression in transfected 293T cell line (H00002101-T04) by ESRRA MaxPab polyclonal antibody.

Lane 1: ESRRA transfected lysate(45.50 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Estrogen-related receptor alpha (C-term) antibody

Mouse Liver; WB Suggested Anti-Esrra Antibody. . Titration: 1.0 ug/ml. . Positive Control: Mouse liver; Esrra antibody - C-terminal region (ARP32259_P050) in Mouse Liver cells using Western Blot Rabbit Aff - Purified Hu, Ms WB
50 µg / €350.00
  AVIVA Systems Biology

Estrogen-related receptor alpha antibody

Transfected 293T; WB Suggested Anti-ESRRA Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: Transfected 293T; ESRRA antibody - N-terminal region (ARP45617_P050) in Transfected 293T cells using Western Blot Rabbit Aff - Purified Can, Hu, Ms, Por, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Estrogen-related receptor alpha antibody

Estrogen-related receptor alpha Mouse IgG2a H5844 Purified Hu, Rt ELISA, IP, P, WB
0.1 ml / €640.00
  Funakoshi Co., Ltd.

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