Estrogen-related receptor alpha antibody

Principal name

Estrogen-related receptor alpha antibody

Alternative names for Estrogen-related receptor alpha antibody

ESRRA, ERR1, ESRL1, NR3B1, Estrogen receptor-like 1, Steroid hormone receptor ERR1, Nuclear receptor subfamily 3 group B member 1

SwissProt ID

O08580 (Mouse), P11474 (Human), Q5QJV7 (Rat), Q6QMY5 (Canfa)

Gene ID

2101 (ESRRA), 26379 (Esrra), 293701

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat), Bov (Bovine), Eq (Equine), GP (Guinea Pig), Ye (Yeast)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Estrogen-related receptor alpha antibody

Estrogen-related receptor alpha (ERR alpha), a NR3 Steroid Receptor, was isolated based on sequence similarity in its DNA-binding domain to estrogen receptor alpha (ER alpha). ERR alpha has been shown to regulate the promoters of lactoferrin, medium-chain acyl CoA dehydrogenase, osteopontin, and thyroid receptor alpha, and it may affect cellular energy balance and bone formation. ERR alpha binds as a monodimer to the extended half-site TNAAGGTCA and as a homodimer to the estrogen response element (ERE) and is a constitutive activator of the estrogen response element and the palindromic thyroid hormone response element (TRE(pal)) but not of the glucocorticoid response element (GRE). ERR alpha 1 is the major isoform expressed in human breast cancer cell lines. Recent studies have shown that Phe-329 is responsible for the constitutive activity of ERR alpha. ERR alpha is a potential biomarker for unfavorable clinical outcome and, possibly, hormonal insensitivity in breast tumors. ERR alpha status may be predictive of sensitivity to hormonal blockade therapy, and ERR alpha status may also be predictive of ErbB2-based therapy such as Herceptin. Moreover, ERR alpha may be a candidate target for therapeutic development. ERRalpha null mice have altered regulation of genes involved in adipogenesis.

In Mouse, ERR alpha is expressed in many adult and embryonic tissues (particularly at the onset of ossification) as well as in several osteoblast cell lines. ERR alpha expression has been documented in mouse in brain, spinal cord, pituitary gland, heart, intestine, bone, brown adipose tissue, heart, uterus, cervix, nerve, skeletal muscle, and vagina.
ESTs have been isolated from human tissue libraries, including cancerous blood, brain, breast, cervix, colon, duodenum, eye, head/neck, kidney, liver, lung, ovary, pancreas, skeletal muscle, skin, stomach, normal adrenal, blood, embryo, heart, prostate, testis and uterus.
Ligand: PPARgamma coactivator 1 (PGC-1) beta

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Estrogen-related receptor alpha antibody

  Rabbit Polyclonal Anti-ESRRA Antibody (Internal)  
Anti-ESRRA antibody IHC of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Ms, Rt P
50 µg / €400.00
  OriGene Technologies, Inc.

Estrogen-related receptor alpha (Center) antibody

  Rabbit polyclonal ESRRA Antibody (Center)  
Flow cytometric analysis of 293 cells using ESRRA Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Rabbit Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Estrogen-related receptor alpha antibody

  Rabbit Polyclonal ERR alpha/NR3B1 Antibody  
Western Blot: Estrogen Related Receptor alpha Antibody [TA336767] - Analysis of ERR alpha in A431 cell lysates Rabbit Purified Hu, Ms C, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Estrogen-related receptor alpha antibody

  Rabbit Polyclonal Anti-Esrra Antibody  
WB Suggested Anti-Esrra Antibody; Titration: 1.0 ug/ml; Positive Control: Mouse liver Rabbit IgG Purified Ms WB
50 µg / €325.00
  OriGene Technologies, Inc.

Estrogen-related receptor alpha antibody

  Rabbit Polyclonal Anti-ESRRA Antibody  
WB Suggested Anti-ESRRA Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Transfected 293T Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rt, Ye WB
50 µg / €325.00
  OriGene Technologies, Inc.

Estrogen-related receptor alpha antibody

  Rabbit Polyclonal Anti-ESRRA Antibody (Ligand-binding Domain)  
Anti-ESRRA antibody IHC of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Ms, Rt P
50 µg / €400.00
  OriGene Technologies, Inc.

Estrogen-related receptor alpha antibody

  ESRRA mouse monoclonal antibody, clone OTI9D10 (formerly 9D10)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ESRRA (RC209028, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ESRRA.(1:2000) Mouse IgG1 OTI9D10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Estrogen-related receptor alpha antibody

  ESRRA mouse monoclonal antibody, clone OTI1E6 (formerly 1E6)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ESRRA (RC209028, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ESRRA.(1:500) Mouse IgG2a OTI1E6 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Estrogen-related receptor alpha antibody

  ESRRA mouse monoclonal antibody, clone OTI2C12 (formerly 2C12)  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-ESRRA mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120 oC for 3 min, TA808637)(1:150) Mouse IgG1 OTI2C12 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Estrogen-related receptor alpha antibody

  ESRRA mouse monoclonal antibody, clone OTI2C10 (formerly 2C10)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ESRRA (RC209028, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ESRRA.(1:2000) Mouse IgG1 OTI2C10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Estrogen-related receptor alpha antibody

  ESRRA mouse monoclonal antibody, clone OTI1C6 (formerly 1C6)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ESRRA (RC209028, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ESRRA.(1:2000) Mouse IgG1 OTI1C6 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Estrogen-related receptor alpha antibody

  ESRRA mouse monoclonal antibody, clone OTI3G10 (formerly 3G10)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ESRRA (RC209028, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ESRRA.(1:2000) Mouse IgG1 OTI3G10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Estrogen-related receptor alpha antibody

  ESRRA mouse monoclonal antibody, clone OTI2G5 (formerly 2G5)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ESRRA (RC209028, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ESRRA.(1:2000) Mouse IgG1 OTI2G5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CRISPR

Catalog No. Species Donor Vector  

ESRRA - human gene knockout kit via CRISPR

ESRRA - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

ESRRA - human gene knockout kit via CRISPR

ESRRA - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

ESRRA - human gene knockout kit via CRISPR

ESRRA - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

ESRRA - human gene knockout kit via CRISPR

ESRRA - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Esrra - mouse gene knockout kit via CRISPR

Esrra - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Esrra - mouse gene knockout kit via CRISPR

Esrra - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Esrra - mouse gene knockout kit via CRISPR

Esrra - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

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