ETV5 / ERM antibody

Principal name

ETV5 / ERM antibody

Alternative names for ETV5 / ERM antibody

ETS translocation variant 5, Ets-related protein ERM

SwissProt ID

P41161 (Human), Q9CXC9 (Mouse)

Gene ID

2119 (ETV5)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), African clawed frog, Ze (Zebrafish), Chk (Chicken), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Flow Cytometry (F)

Background of ETV5 / ERM antibody

The ETS family of transcription factors, characterized by an evolutionarily conserved DNA-binding domain, regulates expression of more than 300 target genes by binding to a purine-rich GGAA/T core sequence. Depending on the cellular context, they can function as transactivators or transrepressors. Ets proteins have been implicated in regulation of gene expression during a variety of biological processes, including growth control, transformation, T-cell activation, and developmental programs in many organisms. Signals regulating cell growth are transmitted from outside the cell to the nucleus by growth factors and their receptors, G-proteins, kinases and transcription factors. It was shown that ETS signal transduction is implicated in hematopoiesis and angiogenesis at the earliest stages of embryogenesis, and is later involved in tissue development. Deregulated expression and/or formation of chimeric fusion proteins of the ETS family due to proviral insertion or chromosome translocation is associated with leukemias and with specific types of solid tumors.  Among the multiple Ets proteins, the PEA3 group consists of ETV1 (Ets variant gene 1; also called ER81), ETV4 (also called PEA3) and ETV5 (also called ERM). All three members are 95% identical in the ETS domain and more than 85% in the acidic transactivation domain. Several studies suggest that the PEA3 group proteins are involved in intestinal tumors, gastric cancer, and breast cancer metastasis. In nearly all Ewing’s sarcoma tumors, EWS, which encodes a RNA-binding protein, is fused by chromosomal translocation to an Ets gene, including FLI, ERG, ETV4, and ETV1. This results in the expression of chimeric proteins that may be important in tumor cell transformation. Recently, it was reported that TMPRSS2, an AR-regulated gene, is fused by translocation to the ETV1, ERG, or ETV4 gene in a subset of prostate cancers. These findings suggest an important role for PEA3 proteins in prostate cancer. In addition Ets family members have been correlated to tumor progression by upregulating the expression of matrix-degrading proteases. The acquisition of a migratory phenotype by the epithelial tumor cells together with the remodeling of the extracellular matrix must accompany the process of cancer cell invasion. Indeed, ETV5 has been shown to act through matrix metalloproteinase-2 gelatinolytic activity to confer invasive capabilities, associated with an initial switch to myometrial infiltration.

General readings

Fontaine-Bisson, B., et al. Diabetologia 53(10):2155-2162(2010)
Lens, Z., et al. Biochem. Biophys. Res. Commun. 399(1):104-110(2010)
Ng, M.C., et al. J. Clin. Endocrinol. Metab. 95(5):2418-2425(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010)
Elks, C.E., et al. PLoS Med. 7 (5), E1000284 (2010).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ETV5 / ERM antibody

WB Suggested Anti-ETV5 Antibody Titration: 0.2-1 ug/ml; Positive Control: Transfected 293T Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

ETV5 / ERM antibody

ETV5 monoclonal antibody (M02), clone 7C10. Western Blot analysis of ETV5 expression in NIH/3T3 ( Cat # L018V1 ). Mouse IgG1 7C10 Purified Hu, Ms, Rt E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

ETV5 / ERM antibody

Transfected 293T; WB Suggested Anti-ETV5 Antibody Titration: 0.2-1 ug/ml. Positive Control: Transfected 293T; ETV5 antibody - N-terminal region (ARP38468_P050) in Transfected 293T cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

ETV5 / ERM (N-term) antibody

Western blot analysis of ETV5 Antibody (N-term) Pab (Cat. #TA324368) pre-incubated without(lane 1) and with(lane 2) blocking peptide in SW480 cell line lysate. ETV5 Antibody (N-term) (arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu F, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

ETV5 / ERM antibody

WB Suggested Anti-ETV5 Antibody Titration: 0.2-1 ug/ml; Positive Control: 293T cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

ETV5 / ERM antibody

Western blot analysis using ETV5 mouse mAb against Jurkat (1), NIH/3T3 (2) and MCF-7 (3) cell lysate. Mouse IgG1 3H3 Ascites Hu E, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

ETV5 / ERM antibody

ETV5 / ERM Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

ETV5 / ERM antibody

ETV5 monoclonal antibody (M01), clone 3B10 Western Blot analysis of ETV5 expression in Hela NE ( Cat # L013V3 ). Mouse IgG1 3B10 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

ETV5 / ERM antibody

Human Lung; WB Suggested Anti-ETV5 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:7812500. Positive Control: Human Lung; ETV5 antibody - N-terminal region (ARP31658_P050) in Human Lung cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

ETV5 / ERM antibody

Human 293T; WB Suggested Anti-ETV5 Antibody Titration: 0.2-1 ug/ml. Positive Control: 293T cell lysate; ETV5 antibody - N-terminal region (ARP32264_P050) in Human 293T cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

ETV5 / ERM antibody

Western Blot: ERM / Etv5 Antibody (3H3) [NBP1-51614] - Western blot analysis using ETV5 mouse mAb against Jurkat (1), NIH/3T3 (2) and MCF-7 (3) cell lysate. Mouse IgG1 3H3 Purified Hu E, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ETV5 / ERM

ETV5 / ERM Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

ETV5 / ERM

ETV5 / ERM Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

13 Item(s)

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