Exostosin-1 antibody

Principal name

Exostosin-1 antibody

Alternative names for Exostosin-1 antibody

EXT1, Multiple exostoses protein 1, Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, Putative tumor suppressor protein EXT1

SwissProt ID

A5D7I4 (Bovin), P97464 (Mouse), Q16394 (Human), Q9JK82 (Crigr)

Gene ID

2131 (EXT1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P)

Background of Exostosin-1 antibody

Hereditary multiple exostoses (EXT) is an autosomal domint disorder characterized by the formation of cartilage-capped tumors (exostoses) that develop from the growth plate of endochondral bone. This condition can lead to skeletal abnormalities, short stature and malignt transformation of exostoses to chondrosarcomas or osteosarcomas. Linkage alyses have identified three different genes for EXT, EXT1 on 8q24.1, EXT2 on 11p11-13 and EXT3 on 19p, a family of tumor suppressor genes. Most EXT cases have been attributed to missense or frameshift mutations, which lead to loss of function of the EXT genes. EXT1 is an ER-resident type II transmembrane glycoprotein and a heparan sulphate polymerase with both D-glucuronyl and N-acetyl-D-glucosaminoglycan transferase activities. Expression of EXT1 in cells results in the alteration of the synthesis and display of cell surface heparan sulfate glycosaminoglycans. EXT1 mutations have been identified in multiple types of human tumors.

General readings

Zuntini, M., et al. Oncogene 29(26):3827-3834(2010)
Wen, W., et al. Genet Test Mol Biomarkers 14(3):371-376(2010)
Li, Y., et al. Pathology 42(1):91-93(2010)
Baasanjav, S., et al. BMC Med. Genet. 11, 110 (2010)
Ludecke, H.J., et al. Genomics 40(2):351-354(1997).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Exostosin-1 antibody

Predicted band size: 86 kDa . Positive control: MDA-MB231 cell lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lysate: 40 ug Primary antibody: 1/5000 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Exostosin-1 antibody

Western blot analysis of extracts of various cell lines, using EXT1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Exostosin-1 (Center) antibody

Western blot analysis of EXT1 Antibody (Center) Cat.-No AP51483PU-N in K562 cell line lysates (35ug/lane). This demonstrates the EXT1 antibody detected the EXT1 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Exostosin-1 antibody

Western Blot analysis of EXT1 expression in transfected 293T cell line (H00002131-T01) by EXT1 MaxPab polyclonal antibody.

Lane 1: EXT1 transfected lysate(86.30 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Exostosin-1 antibody

Detection limit for recombinant GST tagged EXT1 is approximately 3ng/ml as a capture antibody. Mouse IgG2a 5A5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Exostosin-1 antibody

Immunohistochemistry-Paraffin: EXT1 Antibody [NBP1-91875] Immunohistochemical staining of human rectum shows strong membranous and cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Exostosin-1

Exostosin-1 Human
2 µg / €300.00
  Abnova Taiwan Corp.

Exostosin-1

Exostosin-1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Exostosin-1

Exostosin-1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Exostosin-1

Exostosin-1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Exostosin-1

Exostosin-1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

11 Item(s)

per page
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