EZH2 / KMT6 antibody

Principal name

EZH2 / KMT6 antibody

Alternative names for EZH2 / KMT6 antibody

ENX-1, Lysine N-methyltransferase 6, Histone-lysine N-methyltransferase EZH2, Enhancer of zeste homolog 2

SwissProt ID

Q15910 (Human), Q61188 (Mouse)

Gene ID

2146 (EZH2), 14056 (Ezh2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Ze (Zebrafish), African clawed frog, Mky (Monkey), Frog, Prim (Primate), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), ChIP assay (ChIP), Flow Cytometry (F), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of EZH2 / KMT6 antibody

EZH2 (histone methyltransferase enhancer of zeste homolog 2) is a member of polycomb group proteins, and together with embryonic ectoderm development protein and suppressor of Zeste (SUZ12), EZH2 forms the polycomb repressor complex 2 which plays an important role in variety of biological processes such as differentiation, maintaince of cellular identity and proliferation, and stem-cell plasticity. EZH2 contains histone methyltransferase activity and mediates transcriptiol repression of target genes at chromatin level by catalyzing trimethylation of histone H3 lysine 27 (H3K27me3). EZH2 is overexpressed in cancers of diverse origins that includes hematologic maligncies, urothelial/esophageal carcinoma, glioma, rel cell carcinoma, NSCLC, and colorectal, breast and hepatic cancer. Moreover, high expression of EZH2 has been linked to aggressive tumor formation/poor prognosis and EZH2 contributes to the metastasis through the downregulation of E-cadherin by mediating histone H3 methylation. Accordingly, inhibition of EZH2 expression results in significantly decreased cell proliferation and increased G2-M arrest.

General readings

Mural,R.J., (2005) Direct Submission

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

EZH2 / KMT6 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-EZH2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min, TA802907) Mouse IgG1 OTI2B10 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

EZH2 / KMT6 (C-term) antibody

Human prostate cancer stained with anti-EZH2 Antibody Cat.-No AM33207PU (Clone SP129) Rabbit IgG SP129 Purified Frog, Hu, Mky, Ms, Rt F, P, WB
0.5 ml / €520.00
  Acris Antibodies GmbH

EZH2 / KMT6 (C-term) antibody

Human prostate cancer stained with anti-EZH2 Antibody Cat.-No AM33207PU (Clone SP129) Rabbit IgG SP129 Purified Frog, Hu, Mky, Ms, Rt F, P, WB
1 ml / €750.00
  Acris Antibodies GmbH

EZH2 / KMT6 (C-term) antibody

Human prostate cancer stained with anti-EZH2 Antibody Cat.-No AM33207PU (Clone SP129) Rabbit IgG SP129 Purified Frog, Hu, Mky, Ms, Rt F, P, WB
0.1 ml / €290.00
  Acris Antibodies GmbH

EZH2 / KMT6 antibody

Human prostate carcinoma stained with anti-EZH2 antibody Rabbit IgG Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

EZH2 / KMT6 antibody

Human prostate carcinoma stained with anti-EZH2 antibody Rabbit IgG Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

EZH2 / KMT6 antibody

Human prostate carcinoma stained with anti-EZH2 antibody Rabbit IgG Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

EZH2 / KMT6 antibody

Western blot analysis of Ezh2 using rat kidney tissue lysate. Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

EZH2 / KMT6 (N-term) antibody

Western blot analysis of EZH2 in 293 cell lysate with EZH2 antibody at 1 ug/mL. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

EZH2 / KMT6 antibody

Western blot analysis of EZH2 antibody (Cat. #TA324333) in T47D cell line lysates (35ug/lane).EZH2 (arrow) was detected using the purified Mab. Mouse IgG1 144CT2.1.1.5 Purified Hu, Mky ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

EZH2 / KMT6 antibody

Western blot analysis of extracts of various cell lines, using EZH2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

EZH2 / KMT6 antibody

Western Blot: KMT6/EZH2 Antibody [TA336556] - Detection of E2H2 in Jurkat whole cell lysate using TA336556. Rabbit Purified Hu, Ms, Prim WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

EZH2 / KMT6 antibody

WB Suggested Anti-EZH2 Antibody Titration: 1.0 ug/ml; Positive Control: MCF7 cell lysate; EZH2 is supported by BioGPS gene expression data to be expressed in MCF7 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

EZH2 / KMT6 antibody

ChIP assays were performed using 2.5 µg of the ab against EZH2 on sheared chromatin from 5 million E14 mouse embryonic stem and from SUZ12-/- cells, used as a negative control. IgG was used as negative IP control. Quantitative PCR was performed with primers specific for the HoxA10 gene and for the T gene which encodes the Brachyury transcription factor. Image shows the recovery, expressed as a % of input (the relative amount of IP'd DNA compared to input DNA after qPCR analysis). Mouse IgG1 Monoclol Purified Hu, Ms
50 µg / €325.00
  OriGene Technologies, Inc.

EZH2 / KMT6 antibody

EZH2 / KMT6 Rabbit IgG Purified Hu, Ms
0.1 ml / €325.00
  OriGene Technologies, Inc.

EZH2 / KMT6 antibody

WB using the antibody against EZH2 diluted 1:1,000 in TBS-Tween containing 5% skimmed milk. The position of the protein of interest (expected size 85 kDa) is indicated on the right; the marker (in kDa) is shown on the left. Rabbit IgG Purified Hu, Ms
50 µg / €325.00
  OriGene Technologies, Inc.

EZH2 / KMT6 antibody

Western blot analysis of EZH2 expression in HEK293 cell lysate Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

EZH2 / KMT6 antibody

ELISA: KMT6 / EZH2 Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

EZH2 / KMT6 antibody

Immunohistochemical staining of paraffin-embedded Human lymph node tissue within the normal limits using anti-EZH2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA803011) Mouse IgG2b OTI10B10 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

EZH2 / KMT6 control peptide

EZH2 / KMT6
50 µg / €160.00
  Acris Antibodies GmbH

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