F2RL1 / GPR11 / PAR2 antibody

Principal name

F2RL1 / GPR11 / PAR2 antibody

Alternative names for F2RL1 / GPR11 / PAR2 antibody

Proteinase-activated receptor 2, PAR-2, Thrombin receptor-like 1, G-protein coupled receptor 11, Coagulation factor II receptor-like 1

SwissProt ID

P55085 (Human), P55086 (Mouse), Q2HJA4 (Bovin), Q63645 (Rat)

Gene ID

2150 (F2RL1), 116677 (F2rl1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Hst (Hamster), Mky (Monkey), Rb (Rabbit), Gorilla, Bov (Bovine), Can (Canine), Por (Porcine)

Available hosts

Rabbit

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of F2RL1 / GPR11 / PAR2 antibody

Protease-activated receptor 2 (PAR-2) belongs to a family of four G protein-coupled receptors (PAR-1 - 4) that are activated as a result of proteolytic cleavage by certain serine proteases, hence their me. In this novel modality of activation, a specific protease cleaves the PAR receptor within a defined sequence in its extracellular N-termil domain. This results in the creation of a new N-termil tethered ligand, which subsequently binds to a site in the second extracellular loop of the same receptor. This binding results in the coupling of the receptor to G proteins and in the activation of several sigl transduction pathways. Different PARs are activated by different proteases. Hence, PAR-1 is activated by thrombin, as are PAR-3 and PAR-4. PAR-2 is the only PAR family receptor that is activated by trypsin and not by thrombin. PAR-2 can be also cleaved and activated by other proteases such as tryptase, membrane-type serine protease 1, protease 3, and others. The intramolecular ture of PAR activation and the continuous presence of the tethered ligand that cannot diffuse away imply the existence of several mechanisms for the rapid termition of PAR sigling. Indeed, following receptor activation, there is rapid phosphorylation of the C-termil end of the receptor, followed by receptor interlization and degradation. In addition, several proteases can cleave away the tethered ligand, thereby “disarming” the PAR. PAR-2-mediated intracellular sigling has not been clearly elucidated, but activators of PAR-2 induce generation of IP3 and mobilization of intracellular Ca2+. Activation of the ERK1/2 and NF-kB intracellular pathways following PAR-2 activation has been also described. Tissue distribution of PAR-2 is wide with the highest expression levels found in pancreas, small intestine, liver and kidney. In addition, PAR-2 expression was observed in dorsal root ganglion neurons, smooth muscle cells and endothelial cells. The physiological role of PAR-2 is not clearly understood, however studies using PAR-2 knockout mice have suggested roles in the cardiovascular, pulmory and gastrointestil systems. Several studies suggest that PAR-2 plays a central role in inflammatory diseases and nociceptive pain transduction; hence PAR-2 blockers have been proposed to be useful in the therapeutic control of inflammation and pain.

  1. Quick-Filters:
  2. Highly Validated (3)

10 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

F2RL1 / GPR11 / PAR2 (C-term) antibody

Anti-F2RL1 / PAR2 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bov, Can, Elephant, Hst, Hu, Mky, Ms, Op, Por, Prim, Rb P
50 µg / €345.00
  OriGene Technologies, Inc.

F2RL1 / GPR11 / PAR2 (N-term, extracel. dom.) antibody

Anti-F2RL1 / PAR2 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Mky, Prim P
50 µg / €345.00
  OriGene Technologies, Inc.

F2RL1 / GPR11 / PAR2 antibody

Western blot analysis of human breast adenocarcinoma MDA-MB-231(lanes 1 and 4) and MDA-MB-468 (lanes 2 and 5), and human lung small cell carcinoma NCI-H526 (lanes 3 and 6) cell lines: 1-3. Anti-Protease-Activated Receptor-2 antibody , (1:600). 4-6. Anti-Protease-Activated Receptor-2 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

F2RL1 / GPR11 / PAR2 antibody

Anti-F2RL1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Hst, Hu, Mky, Ms, Rt
50 µg / €345.00
  OriGene Technologies, Inc.

F2RL1 / GPR11 / PAR2 antibody

Host: Rabbit; Target Name: F2RL1; Sample Tissue: Hela Whole cell lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

F2RL1 / GPR11 / PAR2

F2RL1 / GPR11 / PAR2 Human
10 µg / €540.00
  Abnova Taiwan Corp.

F2RL1 / GPR11 / PAR2

F2RL1 / GPR11 / PAR2 Human
2 µg / €300.00
  Abnova Taiwan Corp.

F2RL1 / GPR11 / PAR2

F2RL1 / GPR11 / PAR2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

F2RL1 / GPR11 / PAR2

F2RL1 / GPR11 / PAR2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

F2RL1 overexpression lysate

F2RL1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

10 Item(s)

per page
  • LinkedIn