FABP4 antibody

Principal name

FABP4 antibody

Alternative names for FABP4 antibody

A-FABP, Adipocyte lipid-binding protein, Fatty acid-binding protein 4

SwissProt ID

O97788 (Pig), P04117 (Mouse), P15090 (Human), P48035 (Bovin), P70623 (Rat)

Gene ID

2167 (FABP4), 11770 (Fabp4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Rb (Rabbit), Eq (Equine), Gt (Goat), Sh (Sheep), Bov (Bovine)

Available hosts

Rabbit, Mouse, Chicken, Goat

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), EPair for Elisa (EPair)

Background of FABP4 antibody

Adipocyte fatty acid binding protein AFABP is a 15 kDa member of the intracellular fatty acid binding protein (FABP) family, which is known for the ability to bind fatty acids and related compounds (bile acids or retinoids) in an internal cavity. AFABP is expressed in a differentiation-dependent fashion in adipocytes and is a critical gene in the regulation of the biological function of these cells . In mice, targeted mutations in AFABP provide significant protection from hyperinsulinemia and insulin resistance in the context of both dietary and genetic obesity. Adipocytes obtained from AFABP-deficient mice also have reduced efficiency of lipolysis in vitro and in vivo, and these mice exhibited moderately improved systemic dyslipidemia. Recent studies also demonstrated AFABP expression in macrophages upon differentiation and activation. In these cells, AFABP modulates inflammatory responses and cholesterol ester accumulation, and total or macrophage-specific AFABP deficiency confers dramatic protection against atherosclerosis in the apoE-/- mice. These results indicate a central role for AFABP in the development of major components of the metabolic syndrome through its distinct actions in adipocytes and macrophages.

General readings

1. Xu A, Wang Y, Xu JY, Stejskal D, Tam S, Zhang J, Wat NM, Wong WK, Lam KS . Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome. Clin Chem . Mar;52(3):405-13 (2006)
See: http://www.clinchem.org/cgi/content/abstract/52/3/405
2. Prinsen CF, de Bruijn DR, Merkx GF, Veerkamp JH. Assignment of the human adipocyte fatty acid-binding protein gene (FABP4) to chromosome 8q21 using somatic cell hybrid and fluorescence in situ hybridization techniques.
3. van Dongen MJ, Uppenberg J, Svensson S, Lundback T, Akerud T, Wikstrom M, Schultz J. Structure-based screening as applied to human FABP4: a highly efficient alternative to HTS for hit generation.
4. Witthuhn BA, Bernlohr DA. Upregulation of bone morphogenetic protein GDF-3/Vgr-2 expression in adipose tissue of FABP4/aP2 null mice.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FABP4 (1-30) antibody

Adipocytes, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms E, P, WB
0.2 ml / €470.00
  Acris Antibodies GmbH

FABP4 antibody

Western blot analysis of extracts of various cell lines , using FABP4 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

FABP4 antibody

AP32740PU-N FABP4 Antibody staining of Human Adipose lysate at 0.03µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu WB
0.1 mg / €340.00
  Acris Antibodies GmbH

FABP4 antibody

Western blot analysis of Human fetal brain tissue using TA321346(FABP4 Antibody) at dilution 1/100 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

FABP4 antibody

FABP4 Antibody (Cat. #TA328110) western blot analysis in mouse 3T3-L1 cell line and human placenta tissue lysates (35ug/lane).This demonstrates the FABP4 antibody detected the FABP4 protein (arrow). Mouse IgG1 1105CT1.1.1 Purified Hu, Ms WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

FABP4 antibody

WB Suggested Anti-FABP4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Human Spleen Rabbit IgG Purified Can, Eq, Gt, Hu, Ms, Rb, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

FABP4 antibody

WB Suggested Anti-FABP4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human Muscle Rabbit IgG Purified Bov, Can, Eq, Gt, Hu, Rb, Sh P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

FABP4 antibody

Western blot analysis using FABP4 antibody Cat.-No AM06259SU-N against truncated Trx-FABP4 recombinant protein (Lane 1). Mouse IgG1 5H11A4E11 Ascites Hu WB
0.1 ml / €340.00
  Acris Antibodies GmbH

FABP4 antibody

Western blot analysis using FABP4 mouse mAb against FABP4-hIgGFc transfected HEK293 cell lysate. Mouse IgG1 9B8D Ascites Hu E, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

FABP4 antibody

The extracts of mouse heart (40ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human FABP4 (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG1 3F4 Purified Hu, Ms E, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

FABP4 antibody

The extracts of mouse heart (40ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human FABP4 (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG1 3F4 Purified Hu, Ms E, WB
50 µl / €230.00
  Acris Antibodies GmbH

FABP4 (103-118) antibody

Breast, adipocytes: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

FABP4 antibody

Western blot analysis of anti-FABP4 (Cat.#AP12406PU-N) in mouse heart tissue lysates (35ug/lane). FABP4 (arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

FABP4 (C-term) antibody

FABP4 Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

FABP4 antibody

FABP4 Rabbit Azide Free Hu C, WB
50 µg / €370.00
  Acris Antibodies GmbH

FABP4 antibody

FABP4 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

FABP4 antibody

Western Blot analysis of FABP4 expression in transfected 293T cell line (H00002167-T01) by FABP4 MaxPab polyclonal antibody.

Lane1:FABP4 transfected lysate(14.63 KDa).
Lane 2:Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

FABP4 antibody

FABP4 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

FABP4 antibody

FABP4 MaxPab rabbit polyclonal antibody. Western Blot analysis of FABP4 expression in human kidney. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

FABP4 antibody

FABP4 MaxPab rabbit polyclonal antibody. Western Blot analysis of FABP4 expression in human liver. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

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