FADD antibody

Principal name

FADD antibody

Alternative names for FADD antibody

FAS-associated death domain protein, MORT1, GIG3, FAS-associating death domain-containing protein, Mediator of receptor induced toxicity, Growth-inhibiting gene 3 protein

SwissProt ID

Q13158 (Human), Q61160 (Mouse), Q645M6 (Bovin)

Gene ID

8772 (FADD), 14082 (Fadd)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Can (Canine)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), EPair for Elisa (EPair), Flow Cytometry (F)

Background of FADD antibody

FADD (Fas Associated Death Domain) is an apoptosis adapter molecule enabling transduction of the apoptosis signal initiated via the FasL/Fas receptor interaction. The protein contains a C terminal death domain that interacts with the Fas receptor death domain. The N terminus contains a death effectors domain (DED) which recruits caspase to the death inducing signaling complex (DISC) and initiates the apoptotic caspase cascade. Recruitment of Caspase 8 to the Fas receptor results in oligomerization of the Caspase 8 protein, which in turn drives its autoactivation through self-cleavage. Activated Caspase 8 then activates other downstream caspases including Caspase 9, thereby commiting the cell to undergo apoptosis. FADD is implicated in non-apoptotic cellular pathways such as the regulation of cell cycle machinery in T lymphocytes. This is connected to the phosphorylation state of FADD and to the FasL/TRAIL induced transcriptional activation of cfos protooncogene. FADD also interacts with the hepatitis C virus core protein in the HEK 293 cell line.

General readings

1. Imtiyaz HZ et al, I J. Biol. Chem., Vol. 280, Issue 36,
31360-31367, 2005
2. Chinnaiyan AM et al. Cell 81, 505–512, 1995
3. Boldin MP et al, Cell 85, 803–815, 1996.
4. Cohen PL et al. Annu. Rev. Immunol. 9, 243–269, 1991.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FADD antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-FADD Rabbit Polyclonal antibody. (TA590165) Rabbit IgG Purified Can, Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FADD antibody

Paraffin embedded sections of human breast cancer tissue were incubated with anti-human FADD (1:50) for 2 hours at room temperature. Antigen retrieval was performed in 0.1M sodium citrate buffer and detected using Diaminobenzidine (DAB) Mouse IgG2b J1D2 Purified Hu E, P, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

FADD antibody

Paraffin embedded sections of human breast cancer tissue were incubated with anti-human FADD (1:50) for 2 hours at room temperature. Antigen retrieval was performed in 0.1M sodium citrate buffer and detected using Diaminobenzidine (DAB) Mouse IgG2b J1D2 Purified Hu E, P, WB
50 µl / €230.00
  Acris Antibodies GmbH

FADD antibody

Western blot analysis of extracts from HuvEc cells, A549 cells, HeLa cells and JurKat cells, using FADD (Ab-191) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

FADD antibody

Predicted band size: 23 kDa . Positive control: Mouse spleen tissue and RAW264.7 cell lysate. Recommended dilution: 1/1000-5000. (Gel: 8%+12%SDS-PAGE Lane1: Mouse spleen tissue lysate Lane2: Mouse RAW264.7 cell lysate Lysates: 30 ug per lane Primary antibody: 1/550 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 5 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

FADD antibody

Predicted cell location: Cytoplasm. Positive control: Human thyroid and esophagus cancer tissue. Recommended dilution: 1/50-150  The image on the left is immunohistochemistry of paraffin-embedded Human thyroid and esophagus cancer tissue using FADD antibody at dilution 1/50, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

FADD antibody

Western blot analysis of extracts of various cell lines, using FADD antibody. Rabbit IgG Purified Hu, Ms
0.1 mg / €325.00
  OriGene Technologies, Inc.

FADD antibody

Western blot detection of FADD in A431 and Jurkat cell lysates using FADD mouse mAb (1:1000 diluted).Predicted band size:23KDa.Observed band size:23KDa. Mouse IgG1 7C4-F12-F1 Purified WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

FADD antibody

Western blot analysis of extracts (10ug) from 5 different cell lines by using anti-FADD monoclonal antibody at 1:200 dilution. Mouse IgG1 OTI1C11 Purified Hu F, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

FADD antibody

FADD Mouse IgG1 T1B Purified Hu, Ms WB
0.1 mg / €420.00
  Acris Antibodies GmbH

FADD antibody

FADD Mouse IgG1 1A11 Purified Hu E, IP, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

FADD antibody

FADD Mouse IgG1 1A11 Sepharose Hu E, IP, WB
50 Tests / €470.00
  Acris Antibodies GmbH

FADD (1-208) antibody

Western blot analysis of FADD expression in Jurkat (1), HeLa (2), ZR-75-1 (3), NIH/3T3 (4) and WR19L (5) using AM26589AF-N. Mouse IgG1 1F7 Azide Free Hu, Ms WB
0.1 mg / €360.00
  Acris Antibodies GmbH

FADD (1-208) antibody

Western blot analysis of FADD expression in HeLa (1), MRC-5 (2), ZR-75-1 (3), A431 (4), HEp-2 (5), NIH/3T3 (6), WR19L (7) and PC12 (8) using AM26590AF-N. Mouse IgG1 4G3 Azide Free Hu WB
0.1 mg / €360.00
  Acris Antibodies GmbH

FADD control peptide

FADD Purified
50 µg / €190.00
  Acris Antibodies GmbH

FADD antibody

Western blot analysis of FADD expression with Jurkat cell lysates (Lane 1, 2). Rabbit Aff - Purified Hu, Ms, Rt IP, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

FADD antibody

Immunohistochemistry (IHC) analyzes of FADD antibody (Cat.-No.: AP06388PU-N) in paraffin-embedded human lung carcinoma tissue. Rabbit Aff - Purified Hu, Ms P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

FADD pSer191 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu, Ms P, WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

FADD pSer191 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using FADD (Phospho-Ser191) antibody AP55837PU-N (left)or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu, Ms P, WB
0.1 ml / €340.00
  Acris Antibodies GmbH

FADD pSer191 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using FADD (Phospho-Ser191) antibody AP55837PU-N (left)or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu, Ms P, WB
50 µl / €270.00
  Acris Antibodies GmbH

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