FAIM antibody

Principal name

FAIM antibody

Alternative names for FAIM antibody

FAIM1, FAIM-1, Fas Apoptotic Inhibitory Molecule 1

SwissProt ID

Q0IIF6 (Bovin), Q8R5H8 (Rat), Q9NVQ4 (Human), Q9WUD8 (Mouse)

Gene ID

55179 (FAIM), 100362113 (LOC100362113), 23873 (Faim), 140930

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bt (Bat), Can (Canine), Chk (Chicken), Eq (Equine), Hst (Hamster), Mky (Monkey), Op (Opossum), Por (Porcine), Prim (Primate), Rb (Rabbit), Xen (Xenopus), Tr (Turkey), L (Lizard), Bear, Bov (Bovine), Ze (Zebrafish), African clawed frog, GP (Guinea Pig)

Available hosts

Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of FAIM antibody

FAIM (Fas apoptosis inhibitory molecule) was identified as a protein that was inducibly expressed in B lymphocytes resistant to Fas-mediated apoptosis. Expression of FAIM inhibits receptor-mediated apoptosis in B cells as well as other cell types. FAIM is expressed in germil center B cells, is positively regulated by IRF-4, and is also capable of inducing IRF-4 expression in a feed-forward mechanism. FAIM also regulates T cell receptor-mediated apoptosis by modulating Akt activation and Nur77 expression. Knockout mice for FAIM show an increased sensitivity to Fas-mediated apoptosis within B and T cells as well as hepatocytes. An altertively spliced form of FAIM, termed FAIM-L, is found predomintly in the brain. In the nervous system, the origilly identified FAIM does not appear to play a role in apoptosis, but rather can promote neurite outgrowth through the activation of Erk and NF-?B pathways. In contrast, FAIM-L does inhibit neurol cell death triggered by death receptors.

General readings

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Li, G., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (PT 8), 935-937 (2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Kaku, H., et al. J. Immunol. 183(3):1667-1674(2009)
Segura, M.F., et al. J. Neurosci. 27(42):11228-11241(2007).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FAIM antibody

  Goat Polyclonal Antibody against FAIM  
TA303191 (0.5µg/ml) staining of Human Lymph Node lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FAIM antibody

  Rabbit Polyclonal FAIM Antibody  
Western blot analysis of FAIM in human spleen tissue lysate with FAIM antibody at (A) 5 and (B) 10 µg/ml. Rabbit IgG Aff - Purified Hu, Ms E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FAIM antibody

  Anti-FAIM Rabbit Polyclonal Antibody  
Predicted band size: 20 kDa . Positive control: 293 cell lysate. Recommended dilution: 1/500-2000. (Gel: 12%SDS-PAGE Lysate: 40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

FAIM antibody

  Rabbit Polyclonal Anti-FAIM Antibody  
WB Suggested Anti-FAIM Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

FAIM antibody

  Rabbit Polyclonal Anti-FAIM Antibody  
WB Suggested Anti-FAIM Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: OVCAR-3 cell lysate. FAIM is supported by BioGPS gene expression data to be expressed in OVCAR3 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por WB
50 µg / €325.00
  OriGene Technologies, Inc.

FAIM (121-132) antibody

AP08817PU-N staining FAIM in paraffin-embedded Human Placenta by Immunohistochemistry. Goat IgG Aff - Purified Bear, Bt, Can, Chk, Elephant, Eq, Hst, Hu, L, Mky, Ms, Op, Por, Prim, Rb, Rt, Tr, Xen E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

FAIM (Center) antibody

Western blot analysis of FAIM Antibody (Center) Cat.-No AP51510PU-N in HL-60 cell line lysates (35ug/lane). This demonstrates the FAIM antibody detected the FAIM protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

FAIM - human gene knockout kit via CRISPR

FAIM - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

FAIM - human gene knockout kit via CRISPR

FAIM - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

FAIM - human gene knockout kit via CRISPR

FAIM - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

FAIM - human gene knockout kit via CRISPR

FAIM - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Faim - mouse gene knockout kit via CRISPR

Faim - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Faim - mouse gene knockout kit via CRISPR

Faim - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Faim - mouse gene knockout kit via CRISPR

Faim - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Faim - mouse gene knockout kit via CRISPR

Faim - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

FAIM (transcript variant 3)

  Recombinant protein of human Fas apoptotic inhibitory molecule (FAIM), transcript variant 3  
FAIM Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

FAIM (1-213, His-tag)

FAIM Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

FAIM (1-213, His-tag)

FAIM Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

FAIM overexpression lysate

FAIM overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

FAIM overexpression lysate

FAIM overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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