FANCA antibody

Principal name

FANCA antibody

Alternative names for FANCA antibody

Fanconi anemia group A protein, FAA, FACA, FANCH

SwissProt ID

O15360 (Human), Q9JL68 (Mouse), Q9JL70 (Mouse), Q9UEL9 (Human)

Gene ID

2175 (FANCA)

Available reactivities

Hu (Human), Mky (Monkey), Chimp (Chimpanzee), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunoprecipitation (IP)

Background of FANCA antibody

FANCA (Fanconi anemia group A protein) is a D repair protein which plays a key role in post-replication repair, cell cycle checkpoint function, interstrand D cross-link repair and maintence of chromosome stability. FANCA belongs to multisubunit FA complex (FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM) which is absent in FA patients. When complexed with FANCF, FANCG and FANCL (but not with FANCC, nor FANCE), FANCA interacts with HES1 and this interaction is crucial for the stability as well as nuclear localization of FA core complex proteins. FANCA-FANCC/FANCG complex may include EIF2AK2 and HSP70 also and it directly interacts with FAAP20/C1orf86. Localized mainly in the nucleus and cytoplasm, it gets phosphorylated upon D damage through ATM/ATR. FANCA is a most frequently mutated gene in FA (representing 60-70% of the cases) and over 350 unique mutations have been reported which includes large genomic deletions mediated by unusually high density of ALU repetitions found in its genomic sequence. FANCA sequence alterations or its altered expression has been associated with ovarian cancer and leukemia, and homozygous mutations of FANCA have been linked to esophageal cancer. Defects in FANCA are a cause of Fanconi anemia (FA), a rare disorder characterized by physical abnormalities, bone marrow failure (BMF), increased risk of maligncies, and cellular hypersensitivity to D cross-linking agents.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FANCA (995-1009) antibody

Figure 1. Staining FANCA in Brain, Cerebellum by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Aff - Purified Hu, Mky E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

FANCA antibody

Sample (30 ug of whole cell lysate). A: A431 . B: Hela. 12% SDS PAGE. TA308599 diluted at 1:1000. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

FANCA antibody

Immunoprecipitation: FANCA antibody (5G9) - Immunoprecipitation: FANCA Antibody (5G9) - Immunoprecipitated FANCA from wildtype (HSC93) lymphoblasts. (de Winter el al., Hu. Mol. Gen. 9:2665, 2000) Mouse IgG1 5G9 Purified Hu IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

FANCA antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using FANCA antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

FANCA (995-1009) antibody

Western blot using affinity purified anti-FANCA antibody shows detection of FANCA only in FANCA transfected GM6914 cell lysates.  No staining is seen in lysates prepared from FANCA (-/-) cells in the absence of FANCA transfection. Modified from Smogorzewska et al (2007) Cell 129, 289-301. Rabbit IgG Aff - Purified Chimp, Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FANCA antibody

Western Blot: FANCA Antibody [TA336291] - Detection of FANC A in transfected COS1 cell lysate. Rabbit Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

FANCA antibody

Western Blot: FANCA Antibody [TA336575] - Detection of FANCA in 293 EBNA cell lysates using TA336575. Rabbit Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

FANCA antibody

Immunoprecipitation: FANCA Antibody [TA336731] - Lane 1: The Fanconi anemia core complex was obtained by IP from HeLa nuclear extracts with anti-FANCA under high stringency washing conditions, removing BLM, Topo III alpha, BLAP75 and RPA70 as indicated. L Rabbit Purified Hu IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

FANCA (C-term) antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

FANCA antibody

Immunofluorescence of purified MaxPab antibody to FANCA on HeLa cell. [antibody concentration 10 ug/ml] Mouse Serum Hu E(detection), ICC/IF, WB
50 µl / €370.00
  Abnova Taiwan Corp.

FANCA antibody

Immunofluorescence of purified MaxPab antibody to FANCA on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

FANCA antibody

Western blot using FANCA polyclonal antibody ( Cat # PAB10045 ) shows detection of FANCA only in FANCA transfected GM6914 cell lysates.
No staining is seen in lysates prepared from FANCA ( -/- ) cells in the absence of FANCA transfection.
Modified from Smogorzewska et al ( 2007 ) Cell 129, 289-301. Chimp, Hu
0.1 mg / €560.00
  Abnova Taiwan Corp.

FANCA antibody

Western blot analysis of FANCA in transfected COS-1 cell lysate using FANCA polyclonal antibody ( Cat # PAB12429 ). Rabbit Hu WB
0.1 ml / €400.00
  Abnova Taiwan Corp.

FANCA antibody

Western blot analysis of FANCA in 293 EBNA cell lysates using FANCA polyclonal antibody ( Cat # PAB12528 ). Rabbit Hu WB
0.1 ml / €400.00
  Abnova Taiwan Corp.

FANCA pSer1149 antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using FANCA (Phospho-Ser1149) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, P, WB
50 µg / €205.00
  Assay Biotech

FANCA pSer1149 antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using FANCA (Phospho-Ser1149) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, P, WB
0.1 mg / €310.00
  Assay Biotech

FANCA antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using FANCA (Ab-1149) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, P
50 µg / €205.00
  Assay Biotech

FANCA antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using FANCA (Ab-1149) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, P
0.1 mg / €310.00
  Assay Biotech

FANCA pSer1149 antibody

Immunofluorescent analysis of FANCA (pS1149) staining in HepG2 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4  C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, IP, WB
30 µl / €210.00
  Cohesion Biosciences Ltd.

FANCA pSer1149 antibody

Immunofluorescent analysis of FANCA (pS1149) staining in HepG2 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4  C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, IP, WB
0.1 ml / €330.00
  Cohesion Biosciences Ltd.

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