Fascin antibody

Principal name

Fascin antibody

Alternative names for Fascin antibody

SCN1, FAN1, HSN, SNL, p55, Singed-like protein, Dendritic cell marker, 55 kDa actin-bundling protein

SwissProt ID

P85845 (Rat), Q16658 (Human), Q61553 (Mouse)

Gene ID

6624 (FSCN1), 14086 (Fscn1), 1956 (EGFR)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Por (Porcine), Eq (Equine), GP (Guinea Pig), Ze (Zebrafish)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of Fascin antibody

Fascin is a actin cross-linking protein.The Fascin gene contains 5 exons and spans 7 kb. It is a 54-58 kilodalton monomeric actin filament bundling protein originally isolated from sea urchin egg but also found in Drosophila and vertebrates, including humans. Fascin (from the Latin for bundle) is spaced at 11 nanometre intervals along the filament. The bundles in cross section are seen to be hexagonally packed, and the longitudinal spacing is compatible with a model where fascin cross-links at alternating 4 and 5 actins. It is calcium insensitive and monomeric. Fascin binds beta-catenin, and colocalizes with it at the leading edges and borders of epithelial and endothelial cells. The role of Fascin in regulating cytoskeletal structures for the maintenance of cell adhesion, coordinating motility and invasion through interactions with signalling pathways is an active area of research especially from the cancer biology perspective. Abnormal fascin expression or function has been implicated in breast cancer, colon cancer, esophageal squamous cell carcinoma, gallbladder cancer and prostate cancer.

General readings

Wu D., et al. (2010) Ann Oncol. 21(3): 589-596. Shin H., et al. (2009) Phys Rev Left. 103(23): 238102.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Fascin antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-FSCN1 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA807293)(1:150) Mouse IgG1 OTI3B4 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Fascin antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-FSCN1 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA807305)(1:150) Mouse IgG2a OTI5G1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Fascin antibody

AP32962PU-N (1µg/ml) staining of Human Skeletal Muscle lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu, Ms, Rt WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Fascin antibody

Sample (30 ug of whole cell lysate). A: HeLa. B: Hep G2 . 7.5% SDS PAGE. TA308801 diluted at 1:1000 Rabbit IgG Aff - Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Fascin antibody

Immunohistochemistry staining of Paraffin Hodgkin lymphoma tissue by Fascin antibody (dilution: 1:100 - 1:500; visualization of staining: Cytoplasmic) Mouse IgG1 55-k2 Purified Hu P
1 ml / €230.00
  OriGene Technologies, Inc.

Fascin antibody

WB Suggested Anti-Fscn1 Antibody; Titration: 1.0 ug/ml; Positive Control: Mouse Thymus Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Fascin antibody

Formalin-Fixed, Paraffin-Embedded Human Hodgkin’s lymphoma stained with Fascin antibody Cat.-No. AM10085SU-N using peroxidase conjugate and DAB chromogen. Note the cytoplasmic staining of Hodgkin's cells. Mouse IgG1 55K-2 Supernatant Hu, Rt P
1 ml / €600.00
  Acris Antibodies GmbH

Fascin antibody

The Cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human FSCN1 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Lane 1. : HeLa cell lysate 
Lane 2. : HepG2 cell lysate 
Lane 3. : THP-1 cell lysate Mouse IgG2b AT13D2 Purified Hu E, F, ICC/IF, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

Fascin antibody

The Cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human FSCN1 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Lane 1. : HeLa cell lysate 
Lane 2. : HepG2 cell lysate 
Lane 3. : THP-1 cell lysate Mouse IgG2b AT13D2 Purified Hu E, F, ICC/IF, WB
50 µl / €220.00
  Acris Antibodies GmbH

Fascin antibody

Western blot analysis of Fascin Antibody (Center) (AP17358PU-N) in Y79 cell line lysates (35 µg/lane). Fascin (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Fascin pSer39 antibody

Fascin Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

Fascin (N-term) antibody

Mouse Thymus; WB Suggested Anti-Fscn1 Antibody. . Titration: 1.0 ug/ml. . Positive Control: Mouse Thymus; Fscn1 antibody - N-terminal region (ARP46088_P050) in Mouse Thymus cells using Western Blot Rabbit Aff - Purified Hu, Ms WB
50 µg / €350.00
  AVIVA Systems Biology

Fascin antibody

Fascin Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €290.00
  Boster Immunoleader

Fascin antibody

Western Blot:  Fascin Antibody [NBP1-32708] - (30 ug of whole cell lysate) A: HeLa B: Hep G2  7.5% SDS PAGE diluted at 1:1000 Rabbit IgG Hu WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Fascin antibody

Fascin Rabbit Aff - Purified Ms WB
50 µg / €440.00
  Novus Biologicals Inc.

Fascin antibody

Immunohistochemistry-Paraffin: Fascin Antibody [NBP1-91887] - Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells of seminiferus ducts. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Fascin

Fascin Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Fascin (1-493, His-tag)

Fascin Human Purified > 95 % by SDS - PAGE E. coli
0.5 mg / €750.00
  Acris Antibodies GmbH

Fascin (1-493, His-tag)

Fascin Human Purified > 95 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Fascin

Fascin Human
0.1 mg / €380.00
  Abnova Taiwan Corp.

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