Fascin antibody

Principal name

Fascin antibody

Alternative names for Fascin antibody

SCN1, FAN1, HSN, SNL, p55, Singed-like protein, Dendritic cell marker, 55 kDa actin-bundling protein

SwissProt ID

P85845 (Rat), Q16658 (Human), Q61553 (Mouse)

Gene ID

6624 (FSCN1), 14086 (Fscn1), 683788 (LOC683788)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Ze (Zebrafish)

Available hosts

Mouse, Rabbit, Goat

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Fascin antibody

Fascin is a actin cross-linking protein.The Fascin gene contains 5 exons and spans 7 kb. It is a 54-58 kilodalton monomeric actin filament bundling protein originally isolated from sea urchin egg but also found in Drosophila and vertebrates, including humans. Fascin (from the Latin for bundle) is spaced at 11 nanometre intervals along the filament. The bundles in cross section are seen to be hexagonally packed, and the longitudinal spacing is compatible with a model where fascin cross-links at alternating 4 and 5 actins. It is calcium insensitive and monomeric. Fascin binds beta-catenin, and colocalizes with it at the leading edges and borders of epithelial and endothelial cells. The role of Fascin in regulating cytoskeletal structures for the maintenance of cell adhesion, coordinating motility and invasion through interactions with signalling pathways is an active area of research especially from the cancer biology perspective. Abnormal fascin expression or function has been implicated in breast cancer, colon cancer, esophageal squamous cell carcinoma, gallbladder cancer and prostate cancer.

General readings

Wu D., et al. (2010) Ann Oncol. 21(3): 589-596. Shin H., et al. (2009) Phys Rev Left. 103(23): 238102.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Fascin antibody

  FSCN1 mouse monoclonal antibody, clone OTI3B4 (formerly 3B4)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-FSCN1 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA807293)(1:150) Mouse IgG1 OTI3B4 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Fascin antibody

  FSCN1 mouse monoclonal antibody, clone OTI5G1 (formerly 5G1)  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-FSCN1 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA807305)(1:150) Mouse IgG2a OTI5G1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Fascin antibody

AP32962PU-N (1µg/ml) staining of Human Skeletal Muscle lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu, Ms, Rt WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Fascin antibody

  Rabbit polyclonal antibody to Fascin (fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus))  
Sample (30 ug of whole cell lysate). A: HeLa. B: Hep G2 . 7.5% SDS PAGE. TA308801 diluted at 1:1000 Rabbit IgG Aff - Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Fascin antibody

  Mouse Monoclonal Fascin Antibody  
Immunohistochemistry staining of Paraffin Hodgkin lymphoma tissue by Fascin antibody (dilution: 1:100 - 1:500; visualization of staining: Cytoplasmic) Mouse IgG1 55-k2 Purified Hu P
1 ml / €760.00
  OriGene Technologies, Inc.

Fascin antibody

  Rabbit Polyclonal Anti-Fscn1 Antibody  
WB Suggested Anti-Fscn1 Antibody; Titration: 1.0 ug/ml; Positive Control: Mouse Thymus Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Fascin antibody

  Rabbit Polyclonal Anti-FSCN1 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using (FSCN1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Fascin antibody

  Rabbit Polyclonal Anti-FSCN1 Antibody  
Gel: 10%SDS-PAGE, Lysate: 40 ug, Lane 1-2: Raji cells, U937 cells, Primary antibody: (FSCN1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Fascin antibody

Formalin-Fixed, Paraffin-Embedded Human Hodgkin’s lymphoma stained with Fascin antibody Cat.-No. AM10085SU-N using peroxidase conjugate and DAB chromogen. Note the cytoplasmic staining of Hodgkin's cells. Mouse IgG1 55K-2 Supernatant Hu, Rt P
1 ml / €610.00
  Acris Antibodies GmbH

Fascin antibody

The Cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human FSCN1 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Lane 1. : HeLa cell lysate 
Lane 2. : HepG2 cell lysate 
Lane 3. : THP-1 cell lysate Mouse IgG2b AT13D2 Purified Hu E, F, ICC/IF, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

Fascin antibody

The Cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human FSCN1 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Lane 1. : HeLa cell lysate 
Lane 2. : HepG2 cell lysate 
Lane 3. : THP-1 cell lysate Mouse IgG2b AT13D2 Purified Hu E, F, ICC/IF, WB
50 µl / €220.00
  Acris Antibodies GmbH

Fascin antibody

Western blot analysis of Fascin Antibody (Center) (AP17358PU-N) in Y79 cell line lysates (35 µg/lane). Fascin (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Fascin pSer39 antibody

Fascin Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

FSCN1 - human gene knockout kit via CRISPR

FSCN1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

FSCN1 - human gene knockout kit via CRISPR

FSCN1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

FSCN1 - human gene knockout kit via CRISPR

FSCN1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

FSCN1 - human gene knockout kit via CRISPR

FSCN1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Fscn1 - mouse gene knockout kit via CRISPR

Fscn1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Fscn1 - mouse gene knockout kit via CRISPR

Fscn1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Fscn1 - mouse gene knockout kit via CRISPR

Fscn1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

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