Fatty acid synthase antibody

Principal name

Fatty acid synthase antibody

Alternative names for Fatty acid synthase antibody

FASN, FAS

SwissProt ID

P07855 (Rabit), P12276 (Chick), P12785 (Rat), P19096 (Mouse), P49327 (Human), Q71SP7 (Bovin)

Gene ID

2194 (FASN), 14104 (Fasn)

Available reactivities

Hu (Human), Chk (Chicken), Ms (Mouse), Rt (Rat), Fu (Fungi), Gorilla, Hst (Hamster), Por (Porcine), Prim (Primate)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Frozen Sections (C), Immunoprecipitation (IP), EPair for Elisa (EPair)

Background of Fatty acid synthase antibody

Fatty acid synthetase (FASN) is a key player of fatty acid biosynthetic pathway and it catalyzes formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and DPH (de novo lipid synthesis). Localized in cytoplasm and melanosomes, FASN is expressed at low level in normal adult tissues; however, it is significantly upregulated in cancer cells. The FASN expression is regulated by growth factors/growth factor receptors (EGFR and HER2) and steroid hormone /steroid hormone receptors (ER, AR and progesterone receptor). Downstream of the receptors, PI3K-AKT and MAPK sigling mediate FASN expression through SREBP-1c. FASN expression is also controlled by p53 family proteins and SPOT14, lipogenesis-related nuclear protein generally overexpressed in breast cancer. Extracellular stresses including hypoxia and low pH also induce the FASN expression in cancer cells and USP2a stabilises FASN alongwith promotion of its mTOR-dependent selective translatiol induction. FASN activation provides rapidly proliferating tumor cells sufficient amount of lipids for membrane biogenesis and confers growth/survival advantage possibly acting as a metabolic oncogene. Because FASN-inhibitors are selectively toxic to tumor cells, it has emerged as an attractive target for cancer.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Fatty acid synthase antibody

  Rabbit Polyclonal antibody to Fatty Acid Synthase (fatty acid synthase)  
Fatty Acid Synthase antibody [N1], N-term detects FASN protein by Western blot analysis. A. 30 ug PC-12 whole cell lysate/extract. B. 30 ug Rat2 whole cell lysate/extract. 5 % SDS-PAGE. Fatty Acid Synthase antibody [N1], N-term (TA308750) dilution: 1:1000 Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Fatty acid synthase antibody

  Rabbit Polyclonal antibody to Fatty Acid Synthase (fatty acid synthase)  
Sample (50 ug of whole cell lysate). A: mouse liver. 5% SDS PAGE. TA308751 diluted at 1:1000. Rabbit IgG Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Fatty acid synthase antibody

  Rabbit polyclonal FASN Antibody (Center)  
Western blot analysis of FASN Antibody (Center) (Cat. #TA324935) in Ramos cell line lysates (35ug/lane).FASN (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Fatty acid synthase antibody

  Rabbit Polyclonal Fatty Acid Synthase/FASN Antibody  
Western Blot: Fatty Acid Synthase Antibody [TA336642] - Analysis of Fatty Acid Synthase, using TA336642. Samples: 50 ug of total mouse liver lysate. Rabbit Purified Chk, Hst, Hu, Ms, Por, Prim, Rt C, ICC/IF, IP, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Fatty acid synthase antibody

  Mouse monoclonal FASN Antibody (Center) (Ascites)  
FASN Antibody (Center) (Cat. #TA324351) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the FASN antibody detected the FASN protein (arrow). Mouse IgM 497CT15.2.5 Ascites Hu, Ms ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Fatty acid synthase antibody

  Mouse monoclonal FASN Antibody (Center)  
FASN Antibody (Center) (Cat. #TA324352) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the FASN (Center) antibody detected the FASN (Center) protein (arrow). Mouse IgM 497CT15.2.5 Purified Hu, Ms ICC/IF, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Fatty acid synthase antibody

Human Prostate (formalin-fixed, paraffin-embedded) stained with FASN antibody AP22808PU-N followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Ig Fraction Hu E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Fatty acid synthase (2118-2129) antibody

Brain, cortex, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Aff - Purified Fu, Gorilla, Hu P
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

Fasn - mouse gene knockout kit via CRISPR

Fasn - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Fasn - mouse gene knockout kit via CRISPR

Fasn - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Fasn - mouse gene knockout kit via CRISPR

Fasn - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Fatty acid synthase

  Recombinant protein of human fatty acid synthase (FASN)  
Fatty acid synthase Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

FASN overexpression lysate

FASN overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, FASN (Myc-DDK tagged) - Human fatty acid synthase (FASN), 200 uL, >10^7 TU/mL

Lenti ORF particles, FASN (Myc-DDK tagged) - Human fatty acid synthase (FASN), 200 uL, >10^7 TU/mL  
200 µl / €2,280.00
  OriGene Technologies, Inc.

14 Item(s)

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