FBXW7 antibody

Principal name

FBXW7 antibody

Alternative names for FBXW7 antibody

FBW7, FBX30, SEL10, Archipelago homolog, hAgo, SEL-10, hCDC4, F-box/WD repeat-containing protein 7, F-box and WD-40 domain-containing protein 7, F-box protein FBX30

SwissProt ID

Q8VBV4 (Mouse), Q969H0 (Human)

Gene ID

55294 (FBXW7), 50754 (Fbxw7)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Dros (Drosophila), Ms (Mouse), African clawed frog, Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of FBXW7 antibody

FBXW7 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in FBXW7 gene are detected in ovarian and breast cancer cell lines, implicating the gene\'s potential role in the pathogenesis of human cancers.This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene\'s potential role in the pathogenesis of human cancers. Three transcript variants encoding three different isoforms have been found for this gene.

General readings

Lee,J.W., Pathology 40 (3), 305 (2008)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FBXW7 antibody

  FBXW7 mouse monoclonal antibody, clone OTI6F5 (formerly 6F5)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-FBXW7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802869) Mouse IgG2a OTI6F5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FBXW7 antibody

  FBXW7 mouse monoclonal antibody, clone OTI2G7 (formerly 2G7)  
Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-FBXW7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802834) Mouse IgG2a OTI2G7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FBXW7 antibody

  FBXW7 mouse monoclonal antibody, clone OTI13H4 (formerly 13H4)  
Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-FBXW7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802934) Mouse IgG2b OTI13H4 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FBXW7 (599-708) antibody

  FBXW7 / FBW7 Mouse Monoclonal (3D1) Antibody  
Anti-FBXW7 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. Mouse IgG2a 3D1 Purified Hu E, P, WB
50 µg / €450.00
  OriGene Technologies, Inc.

FBXW7 antibody

  Rabbit Polyclonal Anti-FBXW7 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using (FBXW7 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

FBXW7 antibody

  Rabbit Monoclonal anti-FBXW7 Antibody  
Human endometrial adenocarcinoma stained with anti-FBXW7 antibody. Rabbit IgG SP237 Purified Hu F, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

FBXW7 antibody

  FBXW7 mouse monoclonal antibody, clone OTI6H1 (formerly 6H1)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FBXW7 (RC217398, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FBXW7. Mouse IgG1 OTI6H1 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FBXW7 antibody

  FBXW7 mouse monoclonal antibody, clone OTI2E12 (formerly 2E12)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FBXW7 (RC217398, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FBXW7. Mouse IgG2a OTI2E12 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FBXW7 antibody

  FBXW7 mouse monoclonal antibody, clone OTI10B9 (formerly 10B9)  
Immunohistochemical staining of paraffin-embedded Human bladder tissue within the normal limits using anti-FBXW7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA802871) Mouse IgG2a OTI10B9 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FBXW7 antibody

  FBXW7 mouse monoclonal antibody, clone OTI1C7 (formerly 1C7)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FBXW7 (RC217398, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FBXW7. Mouse IgG1 OTI1C7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FBXW7 antibody

  FBXW7 mouse monoclonal antibody, clone OTI4C11 (formerly 4C11)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-FBXW7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802883) Mouse IgG2b OTI4C11 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FBXW7 antibody

  FBXW7 mouse monoclonal antibody, clone OTI4E7 (formerly 4E7)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FBXW7 (RC217398, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FBXW7. Mouse IgG2b OTI4E7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FBXW7 antibody

  Purified FBXW7 mouse monoclonal antibody, clone OTI6B1 (formerly 6B1)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FBXW7 (RC217398, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FBXW7. Mouse IgG2b OTI6B1 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FBXW7 control peptide

FBXW7 Purified
50 µg / €220.00
  Acris Antibodies GmbH

FBXW7 antibody

Western blot analysis using FBXW7 antibody (AP05288PU-N) on human brain lysate. Antibody used at 1 µg/ml dilution and is used alone (1) or incubated with blocking peptide (2). Visualized using mouse anti-rabbit HRP at 1:200K dilution. Rabbit Aff - Purified Hu WB
0.1 mg / €490.00
  Acris Antibodies GmbH

FBXW7 antibody

Western blot using FBXW7 antibody (AP05288SU-N) on human brain lysate (15 µg/lane). Antibody used at 10 µg/ml (1) and 1 µg/ml (2). Secondary antibody, mouse anti-rabbit HRP used at 1:50k dilution. Rabbit Purified Hu WB
0.1 mg / €380.00
  Acris Antibodies GmbH

FBXW7 (N-term) antibody

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Hu E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

FBXW7 - human gene knockout kit via CRISPR

FBXW7 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Fbxw7 - mouse gene knockout kit via CRISPR

Fbxw7 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Fbxw7 - mouse gene knockout kit via CRISPR

Fbxw7 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

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