FERMT3 antibody

Principal name

FERMT3 antibody

Alternative names for FERMT3 antibody

Fermitin family homolog 3, Unc-112-related protein 2, Kindlin-3, MIG2-like protein, KIND3, MIG2B, URP2

SwissProt ID

Q32LP0 (Bovin), Q86UX7 (Human), Q8K1B8 (Mouse)

Gene ID

83706 (FERMT3), 108101 (Fermt3)

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Goat

Available applications

ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of FERMT3 antibody

The three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites. The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 have been shown to play an essential role in integrin-mediated adhesion and spreading. In contrast to the widely expressed KINDLIN1 and KINDLIN2, KINDLIN3 is restricted to hematopoietic cells and is particularly abundant in megakaryocytes and platelets. Several reports describe a transcriptional misregulation of KINDLINs in various types of cancer. A recent study demonstrates that KINDLIN3 is essential for platelet integrin activation and subsequent integrin outside-in signaling, suggesting it may serve as a potential target for the design of therapeutics aimed at specifically disrupting integrin activation in platelets and leukocytes.

General readings

1. Svensson L, Howarth K, McDowall A, Patzak I, Evans R, Ussar S, Moser M, Metin A, Fried M, Tomlinson I, Hogg N.
Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation. Nature medicine 2009 Mar 15 (3): 306-12.
PMID: 19234463

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18 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FERMT3 antibody

  FERMT3 mouse monoclonal antibody, clone OTI3C7 (formerly 3C7)  
Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-FERMT3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120 oC for 3 min, TA807987)(1:150) Mouse IgG1 OTI3C7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FERMT3 antibody

  FERMT3 mouse monoclonal antibody, clone OTI2G2 (formerly 2G2)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-FERMT3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120 oC for 3 min, TA807994)(1:150) Mouse IgG2b OTI2G2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FERMT3 (C-term) antibody

  Goat Anti-URP2 / kindlin-3 Antibody  
TA305691 (1ug/ml) staining of Human Peripheral Blood Mononucleocytes lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FERMT3 antibody

  Rabbit Polyclonal KINDLIN3 Antibody  
Western blot analysis of KINDLIN3 in rat spleen lysate with KINDLIN3 antibody at (A) 1 and (B) 2 µg/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FERMT3 (C-term) antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

FERMT3 - human gene knockout kit via CRISPR

FERMT3 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

FERMT3 - human gene knockout kit via CRISPR

FERMT3 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

FERMT3 - human gene knockout kit via CRISPR

FERMT3 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Fermt3 - mouse gene knockout kit via CRISPR

Fermt3 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Fermt3 - mouse gene knockout kit via CRISPR

Fermt3 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Fermt3 - mouse gene knockout kit via CRISPR

Fermt3 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Fermt3 - mouse gene knockout kit via CRISPR

Fermt3 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

FERMT3 (transcript variant URP2SF)

  Recombinant protein of human fermitin family homolog 3 (Drosophila) (FERMT3), transcript variant URP2SF  
FERMT3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Lysates

Catalog No.    

FERMT3 overexpression lysate

FERMT3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, FERMT3 (mGFP-tagged)-Human fermitin family member 3 (FERMT3), transcript variant URP2LF, 200 uL, >10^7 TU/mL

Lenti ORF particles, FERMT3 (mGFP-tagged)-Human fermitin family member 3 (FERMT3), transcript variant URP2LF, 200 uL, >10^7 TU/mL  
200 µl / €1,510.00
  OriGene Technologies, Inc.

Lenti ORF particles, FERMT3 (mGFP-tagged) - Human fermitin family member 3 (FERMT3), transcript variant URP2SF, 200 uL, >10^7 TU/mL

Lenti ORF particles, FERMT3 (mGFP-tagged) - Human fermitin family member 3 (FERMT3), transcript variant URP2SF, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, FERMT3 (Myc-DDK-tagged)-Human fermitin family member 3 (FERMT3), transcript variant URP2LF, 200 uL, >10^7 TU/mL

Lenti ORF particles, FERMT3 (Myc-DDK-tagged)-Human fermitin family member 3 (FERMT3), transcript variant URP2LF, 200 uL, >10^7 TU/mL  
200 µl / €1,360.00
  OriGene Technologies, Inc.

Lenti ORF particles, FERMT3 (Myc-DDK tagged) - Human fermitin family member 3 (FERMT3), transcript variant URP2SF , 200 uL, >10^7 TU/mL

Lenti ORF particles, FERMT3 (Myc-DDK tagged) - Human fermitin family member 3 (FERMT3), transcript variant URP2SF , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

18 Item(s)

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