FERMT3 antibody

Principal name

FERMT3 antibody

Alternative names for FERMT3 antibody

Fermitin family homolog 3, Unc-112-related protein 2, Kindlin-3, MIG2-like protein, KIND3, MIG2B, URP2

SwissProt ID

Q32LP0 (Bovin), Q86UX7 (Human), Q8K1B8 (Mouse)

Gene ID

83706 (FERMT3), 3837069 (aroE)

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Rt (Rat), Chimp (Chimpanzee)

Available hosts

Mouse, Goat, Rabbit, Rat

Available applications

ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of FERMT3 antibody

The three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites. The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 have been shown to play an essential role in integrin-mediated adhesion and spreading. In contrast to the widely expressed KINDLIN1 and KINDLIN2, KINDLIN3 is restricted to hematopoietic cells and is particularly abundant in megakaryocytes and platelets. Several reports describe a transcriptional misregulation of KINDLINs in various types of cancer. A recent study demonstrates that KINDLIN3 is essential for platelet integrin activation and subsequent integrin outside-in signaling, suggesting it may serve as a potential target for the design of therapeutics aimed at specifically disrupting integrin activation in platelets and leukocytes.

General readings

1. Svensson L, Howarth K, McDowall A, Patzak I, Evans R, Ussar S, Moser M, Metin A, Fried M, Tomlinson I, Hogg N.
Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation. Nature medicine 2009 Mar 15 (3): 306-12.
PMID: 19234463

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FERMT3 antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-FERMT3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120 oC for 3 min, TA807987)(1:150) Mouse IgG1 OTI3C7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FERMT3 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-FERMT3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120 oC for 3 min, TA807994)(1:150) Mouse IgG2b OTI2G2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FERMT3 (C-term) antibody

TA305691 (1ug/ml) staining of Human Peripheral Blood Mononucleocytes lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FERMT3 antibody

Western blot analysis of KINDLIN3 in rat spleen lysate with KINDLIN3 antibody at (A) 1 and (B) 2 µg/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FERMT3 (C-term) antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

FERMT3 Control Peptide

FERMT3
50 µg / €160.00
  Acris Antibodies GmbH

FERMT3 antibody

Immunofluorescence of purified MaxPab antibody to URP2 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

FERMT3 antibody

FERMT3 Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

FERMT3 antibody

FERMT3 Goat Aff - Purified Can, Hu, Ms, Rt E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

FERMT3 antibody

FERMT3 Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €480.00
  Novus Biologicals Inc.

FERMT3 antibody

Western Blot: URP2 Antibody [NBP1-76349] - Analysis of KINDLIN3 in rat spleen lysate with KINDLIN3 antibody at (A) 1 and (B) 2 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

FERMT3 (transcript variant URP2SF)

FERMT3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

FERMT3

FERMT3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

FERMT3

FERMT3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

FERMT3 overexpression lysate

FERMT3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

15 Item(s)

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