FGF21 antibody

Principal name

FGF21 antibody

Alternative names for FGF21 antibody

FGF-21, Fibroblast growth factor 21

SwissProt ID

Q9JJN1 (Mouse), Q9NSA1 (Human)

Gene ID

26291 (FGF21), 105242481 (LOC105242481), 56636 (Fgf21)

Available reactivities

Hu (Human), Rt (Rat), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Mky (Monkey)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of FGF21 antibody

FGF21(Fibroblast growth factor 21) is a protein that in humans is encoded by the FGF21 gene, which is also a member of the fibroblast growth factor (FGF) family. The FGF21 gene is mapped on 19q13.33. Using RT-PCR, Fgf21 was expressed in several types of adipose tissue in mice, including subcutaneous and epididymal fat pads and brown adipose tissue. The level of Fgf21 expression in adipose tissue was comparable to that in liver. FGF21 stimulates glucose uptake in adipocytes but not in other cell types. This effect is additive to the activity of insulin. FGF21 treatment of adipocytes is associated with phosphorylation of FRS2, a protein linking FGF receptors to the Ras/MAP kinase pathway. FGF21 also protects animals from diet-induced obesity when overexpressed in transgenic mice and lowers blood glucose and triglyceride levels when administered to diabetic rodents. Changes in Fgf21 expression due to suckling or nutritional manipulations were associated with changes in circulating free fatty acid and ketone body levels. In differentiated mouse brown adipocytes in culture, Fgf21 treatment increased the expression of thermogenic genes, caused higher total and uncoupled respiration, and enhanced glucose oxidation.

General readings

Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA.
Endocrine Regulation of the Fasting Response by PPARalpha-Mediated Induction of Fibroblast Growth Factor 21.
Metab. 2007 Jun;5(6):415-25.
PMID: 17550777.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FGF21 antibody

  FGF21 mouse monoclonal antibody, clone OTI1H4 (formerly 1H4)  
Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-FGF21 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502953) Mouse IgG1 OTI1H4 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FGF21 antibody

  FGF21 mouse monoclonal antibody, clone UMAB71  
Immunohistochemical staining of paraffin-embedded Human adult heart tissue using anti-FGF21 mouse monoclonal antibody. (UM500059; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB71 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

FGF21 antibody

  FGF21 mouse monoclonal antibody, clone UMAB71  
Immunohistochemical staining of paraffin-embedded Human adult heart tissue using anti-FGF21 mouse monoclonal antibody. (UM500059; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB71 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

FGF21 antibody

  FGF21 mouse monoclonal antibody, clone OTI4B2 (formerly 4B2)  
Immunofluorescent staining of HeLa cells using anti-FGF21 mouse monoclonal antibody (TA502771). Mouse IgG1 OTI4B2 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FGF21 antibody

  FGF21 mouse monoclonal antibody, clone OTI2F10 (formerly 2F10)  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-FGF21 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502772) Mouse IgG2a OTI2F10 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FGF21 antibody

  FGF21 mouse monoclonal antibody, clone OTI4B4 (formerly 4B4)  
Anti-FGF21 mouse monoclonal antibody (TA502786) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY FGF21(RC204538 ). Mouse IgG2b OTI4B4 Purified Hu F, ICC/IF, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

FGF21 antibody

  FGF21 mouse monoclonal antibody, clone OTI9E5 (formerly 9E5)  
Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-FGF21 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502788) Mouse IgG1 OTI9E5 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FGF21 antibody

  Goat Polyclonal Antibody against FGF21  
TA303289 (1µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FGF21 antibody

  Rabbit Polyclonal Anti-FGF21 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using (FGF21 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

FGF21 antibody

  FGF21 mouse monoclonal antibody, clone OTI3G9 (formerly 3G9)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FGF21 (RC204538 , Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FGF21. Mouse IgG1 OTI3G9 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FGF21 antibody

  FGF21 mouse monoclonal antibody, clone OTI1B4 (formerly 1B4)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FGF21 (RC204538, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FGF21. Mouse IgG2b OTI1B4 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FGF21 antibody

  FGF21 mouse monoclonal antibody, clone OTI3E5 (formerly 3E5)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FGF21 (RC204538, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FGF21. Mouse IgG1 OTI3E5 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FGF21 antibody

  FGF21 mouse monoclonal antibody, clone OTI1H5 (formerly 1H5)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FGF21 (RC204538, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FGF21. Mouse IgG1 OTI1H5 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FGF21 antibody

  FGF21 mouse monoclonal antibody, clone OTI9A7 (formerly 9A7)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FGF21 (RC204538, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FGF21. Mouse IgG1 OTI9A7 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FGF21 antibody

  FGF21 mouse monoclonal antibody, clone OTI2F8 (formerly 2F8)  
Anti-FGF21 mouse monoclonal antibody (TA502868) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY FGF21(RC204538 ). Mouse IgG1 OTI2F8 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FGF21 antibody

  FGF21 mouse monoclonal antibody, clone OTI2B9 (formerly 2B9)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FGF21 (RC204538 , Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FGF21. Mouse IgG1 OTI2B9 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FGF21 antibody

  FGF21 mouse monoclonal antibody, clone OTI2E2 (formerly 2E2)  
Anti-FGF21 mouse monoclonal antibody (TA502954) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY FGF21(RC204538). Mouse IgG1 OTI2E2 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FGF21 antibody

  FGF21 mouse monoclonal antibody, clone OTI1A9 (formerly 1A9)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FGF21 (RC204538, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FGF21. Mouse IgG1 OTI1A9 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CRISPR

Catalog No. Species Donor Vector  

FGF21 - human gene knockout kit via CRISPR

FGF21 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

FGF21 - human gene knockout kit via CRISPR

FGF21 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

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