Alternative names for FGF3 antibody
INT-2 proto-oncogene protein, Fibroblast growth factor 3, FGF-3, INT2, Heparin-binding growth factor 3
Frozen Sections (C), Paraffin Sections (P), Western blot / Immunoblot (WB), Neutralisation (NEUT)
Background of FGF3 antibody
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.
This product has been used in:Giatromanolaki A et al. DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer. J Pathol 200:222-8 (2003). PubMed PMID: 12754744