Fibrinogen alpha chain antibody

Principal name

Fibrinogen alpha chain antibody

Alternative names for Fibrinogen alpha chain antibody

FGA

SwissProt ID

P02671 (Human), P02672 (Bovin), P06399 (Rat), P14448 (Chick), P14452 (Horse), P14460 (Pig), P68213 (Canfa)

Gene ID

2243 (FGA)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Eq (Equine), Gt (Goat), Por (Porcine), Rt (Rat), Sh (Sheep)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), ELISA (capture) (E(capture)), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Immunoprecipitation (IP), Radioimmunoassay (R), EPair for Elisa (EPair), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Immunodiffusion (ID)

Background of Fibrinogen alpha chain antibody

Fibrinogen (clotting factor I) is a heat labile beta glycoprotein (molecular weight 340,000) and consists of three pairs of chains bound by disulphide bonds. It is synthesized in hepatocytes under genetic control. It is the precursor of fibrin, which is the key protein constituting the network of the blood clot. Thrombin converts fibrinogen to fibrin by limited proteolysis, releasing the fibrinopeptides A and B (molecular weight 50,000-65,000) and forming fibrin monomers. Fibrin monomers polymerize to fibrin which is stabilized by cross-linking under the influence of factor XIII. The predominant gamma chain of normal fibrinogen (MW 50,000, with higher variants) has a low affinity for platelet binding. 
The normal concentration of fibrinogen in the blood is 2.5 to 3.5 ml /ml, but lower levels are usually adequate for haemostasis. In newborn infants the value is 1.2 to 2.4 mg/ml. Synthesis of foetal fibrinogen may persists for up to 8 weeks, when adult levels are reached. Adult level increase with age and are a risk for heart disease, myocardial infarction and stroke. Fibrinogen is an acute Phase protein and increased levels are found in loosing enteropathies, in severe malnutrition, in tissue necrosis and in malignancy. Extremely high levels are seen in acute pancreatitis and, to a lower extent, in nephritic syndrome. A moderate raise may also been seen during pregnancy and the use of oral contraceptives. Fibrinogen deficiency may be congenital or acquired. If sufficiently severe, it may result in a bleeding disorder. The congenital form is very rare. Acquired hypofibrinogaemia is relatively common, probably indicating increased consumption during intravascular clotting.

General readings

Smolarczyk,K., (2005) Arterioscler. Thromb. Vasc. Biol. 25 (12), 2679-2684

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Fibrinogen antibody

Fibrinogen Rabbit Serum Hu ID, IP, P
1 ml / €200.00
  Acris Antibodies GmbH

Fibrinogen alpha chain antibody

  Goat polyclonal anti-Fibrinogen antibody  
Western Blot of Goat anti-Fibrinogen antibody. Lane 1: Fibrinogen under reducing conditions. Lane 2: none. Load: 1 µg per lane. Primary antibody: Fibrinogen antibody at 1:3000 for overnight at 4°C. Secondary antibody: Dylight 488 conjugated Donkey anti goat secondary antibody at 1:10,000 for 45 min at RT. Block: TBS/MB-070 1 hr RT. Goat Purified Hu E, WB
0.1 mg / €356.00
  OriGene Technologies, Inc.

Fibrinogen alpha chain (N-term) antibody

  Rabbit polyclonal FGA Antibody (N-term)  
FGA Antibody (N-term) (Cat. #TA324872) western blot analysis in human blood plasma tissue lysates (35ug/lane).This demonstrates the FGA antibody detected the FGA protein (arrow). Rabbit Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Fibrinogen alpha chain antibody

  Rabbit Polyclonal Anti-FGA Antibody  
WB Suggested Anti-FGA Antibody Titration: 5.0 ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, Gt, Hu, Ms, Por, Rt, Sh P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Fibrinogen alpha chain antibody

  Rabbit Polyclonal Anti-FGA Antibody  
WB Suggested Anti-FGA Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 12500; Positive Control: Hela cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

Fibrinogen alpha chain (123-135) antibody

  Goat Polyclonal Anti-fibrinogen alpha chain (aa123-135) Antibody  
TA348926 (0.01 ug/ml) staining of Human Platelets lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Fibrinogen alpha chain antibody

  Goat Polyclonal Anti-fibrinogen alpha chain Antibody  
TA348964 (0.01 ug/ml) staining of Platelets lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Fibrinogen alpha chain antibody

Fibrinogen alpha chain Mouse IgM MFB-HB Purified Can, Hu C, E, ICC/IF
1 ml / €310.00
  Acris Antibodies GmbH

Fibrinogen alpha chain (beta, gamma) antibody

Fibrinogen alpha chain Goat Serum Hu E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

Fibrinopeptide A antibody

Fibrinopeptide A Mouse IgG2a 1F7 Purified Hu E
1 mg / €440.00
  HyTest Ltd.

Fibrinopeptide A antibody

Fibrinopeptide A Mouse IgG2b 26E7 Purified Hu E
1 mg / €440.00
  HyTest Ltd.

Fibrinopeptide A antibody

Fibrinopeptide A Mouse IgG2a 49D2 Purified Hu E, E(capture)
1 mg / €440.00
  HyTest Ltd.

CRISPR

Catalog No. Species Donor Vector  

FGA - human gene knockout kit via CRISPR

FGA - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

FGA - human gene knockout kit via CRISPR

FGA - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

FGA - human gene knockout kit via CRISPR

FGA - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

FGA - human gene knockout kit via CRISPR

FGA - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

FGA overexpression lysate

FGA overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, FGA (mGFP-tagged) - Human fibrinogen alpha chain (FGA), transcript variant alpha, 200 uL, >10^7 TU/mL

Lenti ORF particles, FGA (mGFP-tagged) - Human fibrinogen alpha chain (FGA), transcript variant alpha, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, FGA (mGFP-tagged) - Human fibrinogen alpha chain (FGA), transcript variant alpha-E, 200 uL, >10^7 TU/mL

Lenti ORF particles, FGA (mGFP-tagged) - Human fibrinogen alpha chain (FGA), transcript variant alpha-E, 200 uL, >10^7 TU/mL  
200 µl / €1,830.00
  OriGene Technologies, Inc.

Lenti ORF particles, FGA (Myc-DDK tagged) - Human fibrinogen alpha chain (FGA), transcript variant alpha , 200 uL, >10^7 TU/mL

Lenti ORF particles, FGA (Myc-DDK tagged) - Human fibrinogen alpha chain (FGA), transcript variant alpha , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

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