Fibronectin antibody

Principal name

Fibronectin antibody

Alternative names for Fibronectin antibody

FN1, Cold-insoluble globulin, CIG

SwissProt ID

P02751 (Human), P04937 (Rat), P07589 (Bovin), P11276 (Mouse), P11722 (Chick), Q28275 (Canfa), Q28377 (Horse), Q28749 (Rabit), Q91740 (Xenla)

Gene ID

25661 (Fn1), 14268, 2335 (FN1)

Available reactivities

Bov (Bovine), Chk (Chicken), Rt (Rat), Ms (Mouse), Hu (Human), Can (Canine), Av (Birds), Eq (Equine), Fe (Feline), GP (Guinea Pig), Gt (Goat), Por (Porcine), Sh (Sheep), Rb (Rabbit)

Available hosts

Rabbit, Mouse, Sheep, Chicken

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Radioimmunoassay (R), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Immunodiffusion (ID), ELISA (detection) (E(detection)), Flow Cytometry (F)

Background of Fibronectin antibody

Fibronectin is an ubiquitous extracellular glycoprotein that exists in a soluble form in body fluids and in an insoluble form in the extracellular matrix. It plays a major role in many important physiological processes, such as embryogenesis, wound healing, hemostasis and thrombosis. Fibronectin is secreted as a dimer with a monomer molecular weight of 220-250 kDa. Fibronectin is composed of three types of modules organized into functional domains that are resistant to proteolysis and contain binding sites for extracellular matrix proteins, cell surface receptors and circulating blood proteins. In general, fibronectin is synthesized by and present around fibroblasts, endothelial cells, chondrocytes, glial cells, and myocytes. Fibronectin is abundant in the connective tissue matrix and in basement membranes. Extremely high levels of the glycoprotein are found in plasma. Fibronectin has been reported to play a major role in the cardiovascular system, being functionally involved in blood clotting, atherosclerosis, hypertension and myocardial infarction. Fibronectin's importance during cancer progression has further been shown. It represents an active element in the process of T cell activation in the immune cascade triggered by organ transplantation. Fetal fibronectin has been described as a predictor of term lab.

General readings

1. Koya D, Haneda M, Nakagawa H, Isshiki K, Sato H, Maeda S, et al. Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes. FASEB J. 2000 Mar;14(3):439-47. PubMed PMID: 10698958.
2. Austin BA, Liu B, Li Z, Nussenblatt RB. Biologically active fibronectin fragments stimulate release of MCP-1 and catabolic cytokines from murine retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2009 Jun;50(6):2896-902. doi: 10.1167/iovs.08-2495. Epub 2009 Jan 17. PubMed PMID: 19151387. 
3. Lambeth, L.S. et al. (2015) Transgenic chickens over-expressing aromatase have high estrogen levels but maintain a predominantly male phenotype. Endocrinology. : en20151697.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Fibronectin antibody

Western Blot: Fibronectin Antibody [TA336854] - WB analysis of Fibronectin in HepG2 cell lysate. Rabbit Purified Hu, Ms C, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Fibronectin antibody

Western Blot: Fibronectin Antibody (2F4) [TA336913] - Western blot analysis of HeLa (1) and HepG2 (2) whole cell lysates using Fibronectin antibody (2F4) at 2 ug/ml. Mouse IgG1 2F4 Purified Hu E, F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Fibronectin antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-FN1 mouse monoclonal antibody. (TA803782) Dilution: 1:150 Mouse IgG1 OTI3F9 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Fibronectin antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-FN1 mouse monoclonal antibody. (TA803784) Dilution: 1:150 Mouse IgG1 OTI5C1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Fibronectin antibody

Immunohistochemical analysis of paraffin-embedded lung cancer tissues (left) and stomach cancer tissues (right) using FN1 antibody Cat.-No AM06754SU-N with DAB staining. Mouse IgG1 2F4 Ascites Hu E, F, ICC/IF, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

Fibronectin antibody

Western blot analysis using FN1 antibody Cat.-No AM06755PU-N against HEK293 (1) and FN1 (AA: 1965-2176)-hIgGFc transfected HEK293 (2) cell lysate. Mouse IgG1 2F4G2 Purified Hu E, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

Fibronectin antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between HGF and FN1 HeLa cells were stained with anti-HGF rabbit purified polyclonal 1:1200 and anti-FN1 mouse purified polyclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

Fibronectin antibody

Fibronectin Mouse IgG1 HFN7.1 Purified Hu C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Fibronectin antibody

Fibronectin Mouse IgG1 HFN7.1 Purified Hu C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Fibronectin antibody

Fibronectin Mouse IgG1 HFN7.1 Purified Hu C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Fibronectin antibody

Formalin-fixed, paraffin-embedded Human Pancreatic Adenocarcinoma stained with Fibronectin Monoclonal Antibody Cat.-No AM50111PU (Clone SPM539). Mouse IgG1 SPM539 Purified Hu F, ICC/IF, P
0.2 mg / €390.00
  Acris Antibodies GmbH

Fibronectin antibody

Formalin-fixed, paraffin-embedded Human Pancreatic Adenocarcinoma stained with Fibronectin Monoclonal Antibody Cat.-No AM50111PU (Clone SPM539). Mouse IgG1 SPM539 Purified Hu F, ICC/IF, P
0.1 mg / €320.00
  Acris Antibodies GmbH

Fibronectin antibody

Formalin-fixed, paraffin-embedded Human Pancreatic Adenocarcinoma stained with Fibronectin Monoclonal Antibody Cat.-No AM50111PU (Clone SPM539). Mouse IgG1 SPM539 Purified Hu F, ICC/IF, P
20 µg / €160.00
  Acris Antibodies GmbH

Fibronectin antibody

Formalin-fixed, paraffin-embedded human Pancreatic Adenocarcinoma stained with Fibronectin Monoclonal Antibody Cat.-No AM50112PU (Clone SPM246). Mouse IgG1 SPM246 Purified Hu, Ms, Por, Rt F, ICC/IF, P
0.2 mg / €390.00
  Acris Antibodies GmbH

Fibronectin antibody

Formalin-fixed, paraffin-embedded human Pancreatic Adenocarcinoma stained with Fibronectin Monoclonal Antibody Cat.-No AM50112PU (Clone SPM246). Mouse IgG1 SPM246 Purified Hu, Ms, Por, Rt F, ICC/IF, P
0.1 mg / €320.00
  Acris Antibodies GmbH

Fibronectin antibody

Formalin-fixed, paraffin-embedded human Pancreatic Adenocarcinoma stained with Fibronectin Monoclonal Antibody Cat.-No AM50112PU (Clone SPM246). Mouse IgG1 SPM246 Purified Hu, Ms, Por, Rt F, ICC/IF, P
20 µg / €160.00
  Acris Antibodies GmbH

Fibronectin antibody

Fibronectin Mouse IgG1 TV-1 Purified Hu, Ms, Por, Rt C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Fibronectin antibody

Fibronectin Mouse IgG1 TV-1 Purified Hu, Ms, Por, Rt C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Fibronectin antibody

Fibronectin Mouse IgG1 TV-1 Purified Hu, Ms, Por, Rt C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Fibronectin antibody

Fibronectin Mouse IgG1 2755-8 Purified Hu, Ms, Por, Rt C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

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