Filamin-A antibody

Principal name

Filamin-A antibody

Alternative names for Filamin-A antibody

Alpha-filamin, Filamin-1, Non-muscle filamin, FLNA, FLN, FLN1, Endothelial actin-binding protein, Actin-binding protein 280

SwissProt ID

P21333 (Human), Q8BTM8 (Mouse)

Gene ID

2316 (FLNA), 1231690 (actR)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Rb (Rabbit)

Available hosts

Rabbit, Mouse, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), PLA/Proximity ligation assay (PLA), Flow Cytometry (F)

Background of Filamin-A antibody

Filamins are a family of high molecular mass cytoskeletal proteins that organize filamentous actin in networks and stress fibers. Recently it has become clear that filamins anchor various transmembrane proteins to the actin cytoskeleton and provide a scaffold for a wide range of cytoplasmic signaling proteins (1). Actin-binding protein (Filamin A) is a ubiquitous dimeric actin cross-linking phosphoprotein of peripheral cytoplasm, where it promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins (2). The actin-binding domain is near the amino-terminus of the subunit where the amino acid sequence is similar to other actin filament binding proteins, including alpha-actinin, beta-spectrin, dystrophin, and Dictyostelium abp-120. A monoclonal antibody recognizing Filamin A and Fh1 binds to blood vessels, astrocytes, neurofibrillary tangles, neuropil threads, and dystrophic neurites in the AD brain. Detection of Filamin A /Fh1 proteins in these structures suggests that these presenilin-interacting proteins may be involved in the development of Alzheimer's disease and that interactions between presenilins and Filamin A /Fh1 may be functionally significant (3).

General readings

1. Mizuhashi K  et al. Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements. Hum Mol Genet N/A:N/A (2014). Mouse .
2. Mooso BA  et al. Enhancing the effectiveness of androgen deprivation in prostate cancer by inducing Filamin A nuclear localization. Endocr Relat Cancer 19:759-77 (2012). ICC/IF ; Human .
3. Gawecka JE  et al. RSK2 Protein Suppresses Integrin Activation and Fibronectin Matrix Assembly and Promotes Cell Migration. J Biol Chem 287:43424-37 (2012). WB .
4. Sayner SL  et al. Filamin A is a phosphorylation target of membrane but not cytosolic adenylyl cyclase activity. Am J Physiol Lung Cell Mol Physiol 301:L117-24 (2011). WB,ICC/IF ; Rat .
5. Cooper J  et al. Filamin a protein interacts with human immunodeficiency virus type 1 gag protein and contributes to productive particle assembly. J Biol Chem 286:28498-510 (2011).Flow Cyt ; Human .

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Filamin-A antibody

Immunoperoxidase of monoclonal antibody to FLNA on formalin-fixed paraffin-embedded human lymphoma tissue. [antibody concentration 1.5ug/ml] Mouse IgG1 4E10-1B2 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Filamin-A antibody

Western blot analysis of extracts from 293 cells treated with EGF (200ng/ml, 5mins), using Filamin A (Ab-2152) antibody (#TA313882, Line 1 and 2).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Filamin-A antibody

Western blot analysis of Filamin A expression in EGF treated 293 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Filamin-A antibody

FLNA Antibody (Cat. #TA328181) western blot analysis in PC-3ïrat C6 cell line lysates (35ug/lane).This demonstrates the FLNA antibody detected the FLNA protein (arrow). Mouse IgG1 1273CT424.104.153 Purified Hu, Rt WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Filamin-A (662-676) antibody

TA329075 (0.1µg/ml) staining of Human Uterus lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Filamin-A antibody

Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 4E10-1B2 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

Filamin-A antibody

Immunohistochemistry analysis of Filamin A Antibody (Cat.-No AP06123PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Filamin-A antibody

Filamin-A Mouse IgG1 3B6-1D10 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Filamin-A pSer2152 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using Filamin A (Phospho-Ser2152) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

Filamin-A pSer2152 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using Filamin A (Phospho-Ser2152) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

Filamin-A antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Filamin A (Ab-2152) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

Filamin-A antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Filamin A (Ab-2152) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

Filamin-A antibody

Immunohistochemical analysis of Filamin A staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rb, Rt IP, P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Filamin-A antibody

Immunohistochemical analysis of Filamin A staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rb, Rt IP, P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Filamin-A antibody

Immunohistochemical analysis of Filamin A staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rb, Rt IP, P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

Filamin-A pSer2152 antibody

Immunohistochemical analysis of Filamin A (pS2152) staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Rt IP, P, WB
30 µl / €210.00
  Cohesion Biosciences Ltd.

Filamin-A pSer2152 antibody

Immunohistochemical analysis of Filamin A (pS2152) staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Rt IP, P, WB
0.1 ml / €330.00
  Cohesion Biosciences Ltd.

Filamin-A pSer2152 antibody

Immunohistochemical analysis of Filamin A (pS2152) staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Rt IP, P, WB
0.2 ml / €530.00
  Cohesion Biosciences Ltd.

Filamin-A antibody

Filamin-A Rabbit Hu E, WB
50 µg / €400.00
  Novus Biologicals Inc.

Filamin-A antibody

Western Blot: Filamin A Antibody [NB100-58812] - Detection of Human Filamin A by Western Blot.  Samples: Whole cell lysate (5, 15 and 50 mcg for WB) from HeLa cells.  Antibody:  Affinity purified rabbit anti-Filamin A antibody NB100-58812 used for WB at 0.04 mcg/ml.  Detection:  Chemiluminescence with an exposure time of 30 seconds. Rabbit Aff - Purified Hu P, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

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