FIS1 / TTC11 antibody

Principal name

FIS1 / TTC11 antibody

Alternative names for FIS1 / TTC11 antibody

Mitochondrial fission 1 protein, FIS1 homolog, Tetratricopeptide repeat protein 11, TPR repeat protein 11

SwissProt ID

P40515 (Yeast), P84817 (Rat), Q3T0I5 (Bovin), Q9CQ92 (Mouse), Q9Y3D6 (Human)

Gene ID

51024 (FIS1), 66437 (Fis1), 288584

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Frozen Sections (C)

Background of FIS1 / TTC11 antibody

Principal mes: CGI-135, Fis1, Fis1 homolog, H_NH0132A01.6, tetratricopeptide repeat domain 11, TPR repeat protein 11 ; Claudin 15; CLDN15; TTC11 Official Gene Symbol: TTC11 Gene ID: 51024 (Human) Gene Map Locus: 7q22.1 (Human) Fis1, a 17KDa integral membrane protein, is a novel member of mitochondrial fission machinery. It consists of a central leucine-zipper domain, a coiled-coil region, a tetratricopeptide repeat domain and a C-termil transmembrane domain. It is a human orthologue of Fis1p (S.cerevisiae) and is localized in the outer mitochondrial membrane. Fis1 acts as a pro-apoptotic factor and plays a vital role in the regulation of mitochondrial fission. It interacts with DLP1 and Mdv1p and facilitates Dnm1p recruitment to the functiol fission complex, thereby inducing apoptosis. Role of Fis1 has also been implicated in growth and division of peroxisomes. Loss of Fis1 inhibits apoptosis and results in elongation of mammalian mitochondria.

General readings

Martinou JC., et al. (2003) J Biol Chem. 278(38):36373-9.
Yoon Y., et al. (2008) Exp Cell Res. 314(19):3494-507.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FIS1 / TTC11 antibody

  Rabbit Polyclonal antibody to TTC11 (fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae))  
Sample (50 ug of whole cell lysate). A: mouse brain. 15% SDS PAGE. TA308514 diluted at 1:5000. Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

FIS1 / TTC11 antibody

  Rabbit anti-FIS1 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using FIS1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

FIS1 / TTC11 antibody

  Rabbit Polyclonal TTC11 Antibody  
Western Blot: TTC11 Antibody [TA336435] - A. Analysis of Fis1 in A) human HeLa and B) mouse NIH 3T3 lysate using Fis1 antibody at 1:1000 dilution. B. Specificity validation of the Fis1 antibody. Fis1 was analyzed in M17 cells stably transfected with vecto Rabbit Purified Hu, Ms, Rt P, WB
0.2 ml / €325.00
  OriGene Technologies, Inc.

FIS1 / TTC11 antibody

  Rabbit Polyclonal Anti-FIS1 Antibody  
Gel: 10%SDS-PAGE, Lysate: 40 ug, Lane 1-3: Raji cells, mouse liver tissue, Mouse heart tissue, Primary antibody: (FIS1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

FIS1 / TTC11 antibody

FIS1 / TTC11 Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, IP, WB
0.1 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

FIS1 - human gene knockout kit via CRISPR

FIS1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

FIS1 - human gene knockout kit via CRISPR

FIS1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Fis1 - mouse gene knockout kit via CRISPR

Fis1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Fis1 - mouse gene knockout kit via CRISPR

Fis1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Fis1 - mouse gene knockout kit via CRISPR

Fis1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Fis1 - mouse gene knockout kit via CRISPR

Fis1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

FIS1 / TTC11

  Recombinant protein of human fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) (FIS1), nuclear gene encoding mitochondrial protein  
FIS1 / TTC11 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

FIS1 / TTC11 (1-122, His-tag)

FIS1 / TTC11 Human Purified > 95 % by SDS - PAGE E. coli
0.5 mg / €670.00
  Acris Antibodies GmbH

FIS1 / TTC11 (1-122, His-tag)

FIS1 / TTC11 Human Purified > 95 % by SDS - PAGE E. coli
0.1 mg / €250.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

FIS1 overexpression lysate

FIS1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, FIS1 (mGFP-tagged) - Human fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) (FIS1), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL

Lenti ORF particles, FIS1 (mGFP-tagged) - Human fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) (FIS1), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, FIS1 (Myc-DDK tagged) - Human fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) (FIS1), nuclear gene encoding mitochondrial protein , 200 uL, >10^7 TU/mL

Lenti ORF particles, FIS1 (Myc-DDK tagged) - Human fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) (FIS1), nuclear gene encoding mitochondrial protein , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Fis1 (GFP-tagged) - Mouse fission 1 (mitochondrial outer membrane) homolog (yeast) (Fis1), nuclear gene encoding mitochondrial protein, transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Fis1 (GFP-tagged) - Mouse fission 1 (mitochondrial outer membrane) homolog (yeast) (Fis1), nuclear gene encoding mitochondrial protein, transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Fis1 (GFP-tagged) - Mouse fission 1 (mitochondrial outer membrane) homolog (yeast) (Fis1), nuclear gene encoding mitochondrial protein, transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Fis1 (GFP-tagged) - Mouse fission 1 (mitochondrial outer membrane) homolog (yeast) (Fis1), nuclear gene encoding mitochondrial protein, transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Fis1 (Myc-DDK-tagged) - Mouse fission 1 (mitochondrial outer membrane) homolog (yeast) (Fis1), nuclear gene encoding mitochondrial protein, transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Fis1 (Myc-DDK-tagged) - Mouse fission 1 (mitochondrial outer membrane) homolog (yeast) (Fis1), nuclear gene encoding mitochondrial protein, transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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