FIV p24 gag antibody

Principal name

FIV p24 gag antibody

Alternative names for FIV p24 gag antibody

Feline Immunodeficiency Virus Capsid protein p24

SwissProt ID

P16087 (Fivpe)

Ncbi ID

11674

Available reactivities

Fe (Feline), Vi (Virus)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Flow Cytometry (F), Immunoprecipitation (IP), Frozen Sections (C), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of FIV p24 gag antibody

Feline immunodeficiency virus (FIV) belongs to the lentivirus family. This family is characterized by assembly of the viral capsid at either the plasma membrane or at the limiting membrane of late endosomes. The capsid assembles from the viral Gag polyprotein. Upon release of a budding virion, Gag precursor protein is cleaved by the viral protease into its mature products, namely Matrix Protein, Capsid and Nucleocapsid. Matrix Protein, located at the N-terminus of the Gag polyprotein, is usually myristylated during protein translation, prior to the later events of virus assembly. The myristate moiety is believed to be sequestered within the Matrix Protein during protein translation and later facilitates membrane binding upon exposure resulting from conformational changes. Essential functions attributed to the Matrix Protein of lentiviruses include targeting newly synthesized Gag precursor proteins to the site of virus assembly by binding with cellular components such as phosphatidylinositides. In the mature virus particle, the Matrix Protein provides internal structure to the virion within the capsid, but is not exposed at the surface of the particle. Based on studies with HIV, it is postulated that FIV Matrix Protein may also serve additional functions, including nuclear localization of the viral core upon entry of the virus into a new host cell.

General readings

1. Lerner, D.L. et al. (1995) Increased mutation frequency of Feline Immunodeficiency Virus lacking functional deoxyuridine-triphosphatase. Proc. Natl. Acad. Sci. 92: 7480-7484.
2. Chatterji, U. et al. (2000) Feline Immunodeficiency Virus Vif localises to the nucleus. J. Virol. 74: 2533-2540.
3. Norway, R. M. et al. (2001) Thymic lesions in cats infected with a pathogenic molecular clone or an ORF-A/2 -
deficient molecular clone of Feline Immunodeficiency Virus. J. Virol. 75: 5833-5841.
4. Simon, J.H.M. et al. (1997) The Vif and Gag proteins of human immunodeficiency virus type 1 colocalize in infected human T cells. J. Virol. 71: 5259-5267.

10 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FIV p15 gag antibody

Western blot using affinity purified anti-FIV Matrix Protein p15 to detect p15 in the culture supernatant of FIV-infected feline CrFK cells (lane 2, arrowhead). Lane 1 is an uninfected control. Virions were enriched by ultracentrifugation, lysed, resolved by electrophoresis, and transferred to nitrocellulose. The membrane was probed with the primary antibody at a 1:10,000 dilution. Rabbit IgG Aff - Purified Fe E, ICC/IF, WB
0.1 mg / €440.00
  Acris Antibodies GmbH

FIV p15 gag antibody

Western blot using Matrix Protein p15 polyclonal antibody ( Cat # PAB10208 ) to detect p15 in the culture supernatant of FIV-infected feline CrFK cells ( lane 2, arrowhead ).
Lane 1 is an uninfected control.
Virions were enriched by ultracentrifugation, lysed, resolved by electrophoresis, and transferred to nitrocellulose.
The membrane was probed with the primary antibody at a 1:10,000 dilution.
Personal Communication, B. Luttge, CCR-NCI, Frederick, MD. Rabbit IgG E, ICC/IF, WB
0.1 mg / €560.00
  Abnova Taiwan Corp.

FIV p15 gag antibody

Western Blot: Gag polyprotein Antibody [NBP1-78117] detect p15 in the culture supernatant of FIV-infected feline CrFK cells (lane 2, arrowhead). Lane 1 is an uninfected control. Virions were enriched by ultracentrifugation, lysed, resolved by electrophoresis, and transferred to nitrocellulose. The membrane was probed with the primary antibody at a 1:10,000 dilution. Rabbit Aff - Purified Vi E, WB
0.1 mg / €510.00
  Novus Biologicals Inc.

FIV p24 gag antibody

FIV p24 gag Mouse IgG1 P24CR1 Purified E, WB
0.25 mg / €570.00
  Acris Antibodies GmbH

FIV p24 gag antibody

FIV p24 gag Mouse IgG3 6A9 Ig Fraction E, F, WB
0.2 mg / €530.00
  Acris Antibodies GmbH

FIV p24 gag antibody

FIV p24 gag Mouse IgG1 vpg50 Supernatant F, IP, WB
2 ml / €450.00
  Acris Antibodies GmbH

FIV p24 gag antibody

FIV p24 gag Mouse IgG1 PAK3-2C1 Biotin E
0.25 mg / €420.00
  Acris Antibodies GmbH

FIV p24 gag antibody

FIV p24 gag Mouse IgG1 PAK3-2C1 Aff - Purified C, E, F, P, WB
0.25 mg / €540.00
  Acris Antibodies GmbH

FIV p24 gag antibody

FIV p24 gag Mouse IgG1 PAK3-2C1 Aff - Purified C, E, F, ICC/IF, WB
0.125 mg / €400.00
  Novus Biologicals Inc.

FIV p24 gag antibody

FIV p24 gag Mouse IgG1 vpg50 Supernatant IP, WB
1 ml / €360.00
  Novus Biologicals Inc.

10 Item(s)

per page
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