FKBP1A / FKBP12 antibody

Principal name

FKBP1A / FKBP12 antibody

Alternative names for FKBP1A / FKBP12 antibody

PPIase FKBP1A, FK506-binding protein 1A, Rotamase, Immunophilin FKBP12, Peptidyl-prolyl cis-trans isomerase FKBP1A

SwissProt ID

O42123 (Xenla), P18203 (Bovin), P26883 (Mouse), P62942 (Human), P62943 (Rabit), Q62658 (Rat)

Gene ID

2280 (FKBP1A), 14225 (Fkbp1a)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of FKBP1A / FKBP12 antibody

FKBP12 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. There is evidence of multiple alternatively spliced transcript variants for this gene, but the full length nature of some variants has not been determined.

Immunophilins are a family of soluble receptors capable of binding to one of two major immunosuppressant agents; cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Immunophilins function as cis-trans peptidyl-prolyl isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. Thus, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline-containing proteins.

FKBP12:FK506 complexes inhibit calcineurin, a calcium/calmodulin-dependent serine/threonine phosphatase which blocks T-cell activation by preventing lymphokine gene transcription. FKBP12 also plays a role in intracellular calcium regulation by associating with three types of calcium release channel complexes, cardiac and skeletal ryanodine receptors and the inositol 1,4,5-trisphosphate receptor. In interactions with members of the TGF beta family type I receptors, FKBP12 has been shown to exert an inhibitory effect on the signaling pathway.

General readings

Wesselborg S et al. Identification of a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp). J Biol Chem 271:1274-7 (1996). PubMed PMID: 8576111
Marks AR Cellular functions of immunophilins. Physiol Rev 76:631-49 (1996). PubMed PMID: 8757784

  1. Quick-Filters:
  2. Highly Validated (1)

Items 1 to 20 of 21 total

per page
Page:
  1. 1
  2. 2

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FKBP1A / FKBP12 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-FKBP1A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500557) Mouse IgG2b OTI3B3 Purified Hu F, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

FKBP1A / FKBP12 antibody

Western blot analysis of FKBP12 expression in rat kidney tissue lysate. Rabbit Aff - Purified Bov, Hu, Ms, Rb, Rt IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FKBP1A / FKBP12 antibody

Predicted band size: 12 kDa . Positive control: Mouse cerebellum tissue lysate. Recommended dilution: 1/500-2000. (Gel: 12%SDS-PAGE Lysate: 40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

FKBP1A / FKBP12 antibody

Western blot analysis of FKBP12 in A431 cell lysate with FKBP12 antibody at 1 ug/mL. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FKBP1A / FKBP12 antibody

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with FKBP12 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P
0.4 ml / €370.00
  Acris Antibodies GmbH

FKBP1A / FKBP12 antibody

FKBP1A /  FKBP12 Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

FKBP1A / FKBP12 antibody

Western Blot analysis of FKBP1A expression in transfected 293T cell line by FKBP1A monoclonal antibody (M01), clone 1E5-A12.

Lane 1: FKBP1A transfected lysate(12 KDa).
Lane 2: Non-transfected lysate. Mouse IgG1 1E5-A12 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

FKBP1A / FKBP12 antibody

Western blot analysis of Fkbp1a expression in rat kidney tissue lysate. Rabbit Bov, Hu, Ms, Rb, Rt C, IP, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

FKBP1A / FKBP12 antibody

FKBP1A /  FKBP12 Rabbit Aff - Purified Hu, Ms, Rt IP, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

FKBP1A / FKBP12 antibody

Western Blot: FKBP12 Antibody (EPR3888) [NBP1-40809] - Western blot analysis on (A) fetal brain, (B) U937 and (C) SH-SY5Y cell lysates using anti-FKBP12 Rabbit IgG EPR3888 Hu, Ms, Rt ICC/IF, WB
0.1 ml / €480.00
  Novus Biologicals Inc.

FKBP1A / FKBP12 antibody

Western Blot: FKBP12 Antibody [NBP1-45570] - Western blot analysis of FKBP12 expression in rat kidney tissue lysate. Rabbit IgG Aff - Purified Hu, Ms, Rt IP, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

FKBP1A / FKBP12 (transcript variant 12A)

FKBP1A /  FKBP12 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

FKBP1A / FKBP12 (transcript variant 12B)

FKBP1A /  FKBP12 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

FKBP1A / FKBP12 (1-108, His-tag)

FKBP1A /  FKBP12 Human Purified > 95 % by SDS - PAGE E. coli
0.5 mg / €670.00
  Acris Antibodies GmbH

FKBP1A / FKBP12 (1-108, His-tag)

FKBP1A /  FKBP12 Human Purified > 95 % by SDS - PAGE E. coli
0.1 mg / €250.00
  Acris Antibodies GmbH

FKBP1A / FKBP12 (1-108, His-tag)

FKBP1A /  FKBP12 Mouse Purified > 95 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

FKBP1A / FKBP12 (1-108, His-tag)

FKBP1A /  FKBP12 Mouse Purified > 95 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

FKBP1A / FKBP12

FKBP1A /  FKBP12 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

FKBP1A / FKBP12

FKBP1A /  FKBP12 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

FKBP1A / FKBP12

FKBP1A /  FKBP12 Human
0.1 mg / €330.00
  Abnova Taiwan Corp.

Items 1 to 20 of 21 total

per page
Page:
  1. 1
  2. 2
  • LinkedIn