FKBP4 antibody

Principal name

FKBP4 antibody

Alternative names for FKBP4 antibody

FK506-binding protein 4, FKBP52 protein, FKBP59, p59 protein, Peptidyl-prolyl cis-trans isomerase, PPIase, HSP-binding immunophilin, HBI, 52 kDa FK506-binding protein, Rotamase

SwissProt ID

P27124 (Rabit), P30416 (Mouse), Q02790 (Human), Q9QVC8 (Rat), Q9TRY0 (Bovin)

Gene ID

2288 (FKBP4), 14228 (Fkbp4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Hst (Hamster), Por (Porcine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), EPair for Elisa (EPair), Flow Cytometry (F)

Background of FKBP4 antibody

Hsp90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones (1). One class of Hsp90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an Hsp90 binding site. Among the TPR cochaperones of Hsp90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin Abinding families of immunophilins (2).
FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex (3).
The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the Hsp90 (4).
Although FKBP52 and FKBP51 share ~75% sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different Hsp90-binding characteristics (3, 5). Also, whereas FKBP51 typically has a role with the progesterone receptor, FKBP52 has been found to be linked to the progesterone, androgen and glucocorticoid receptors (5).

General readings

Ruan B, Pong K, Jow F, Bowlby M, Crozier RA, Liu D, Liang S, Chen Y, Mercado ML, Feng X, Bennett F, von Schack D, McDonald L, Zaleska MM, Wood A, Reinhart PH, Magolda RL, Skotnicki J, Pangalos MN, Koehn FE, Carter GT, Abou-Gharbia M, Graziani EI.
Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities.
Proc. Natl. Acad. Sci. U.S.A. 2008 Jan 105 (1): 33-8.
PMID: 18162540

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FKBP4 antibody

Immunohistochemistry: Paraffin embedded sections of Seminoma (Germ cell tumor) tissue were incubated with anti-human FKBP4 (1:50) for 2 hours at room temperature. Antigen retrieval was performed in 0.1M sodium citrate buffer and  Diaminobenzidine (DAB) was used for detection. Mouse IgG2b AT4D3 Purified Hu E, P, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

FKBP4 antibody

Immunohistochemistry: Paraffin embedded sections of Seminoma (Germ cell tumor) tissue were incubated with anti-human FKBP4 (1:50) for 2 hours at room temperature. Antigen retrieval was performed in 0.1M sodium citrate buffer and  Diaminobenzidine (DAB) was used for detection. Mouse IgG2b AT4D3 Purified Hu E, P, WB
50 µl / €230.00
  Acris Antibodies GmbH

FKBP4 antibody

FKBP4 antibody detects FKBP4 protein by Western blot analysis. A. 30 ug Rat2 whole cell lysate/extract. 10 % SDS-PAGE. FKBP4 antibody (TA308638) dilution: 1:1000 Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

FKBP4 antibody

Immunoperoxidase of purified MaxPab antibody to FKBP4 on formalin-fixed paraffin-embedded human esophagus. [antibody concentration 3 ug/ml] Mouse Serum Hu E(detection), ICC/IF, P, WB
50 µl / €370.00
  Abnova Taiwan Corp.

FKBP4 antibody

Immunoperoxidase of purified MaxPab antibody to FKBP4 on formalin-fixed paraffin-embedded human esophagus. [antibody concentration 3 ug/ml] Mouse Purified Hu E(detection), ICC/IF, P, WB
50 µg / €370.00
  Abnova Taiwan Corp.

FKBP4 antibody

FKBP4 MaxPab rabbit polyclonal antibody. Western Blot analysis of FKBP4 expression in mouse spleen. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

FKBP4 antibody

Immunoperoxidase of monoclonal antibody to FKBP4 on formalin-fixed paraffin-embedded human uterine cervix. [antibody concentration 0.5 ug/ml] Mouse IgG2a 5C11 Purified Hu, Ms, Rt E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

FKBP4 (C-term) antibody

TA305784 (0.01ug/ml) staining of Human Placenta lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FKBP4 antibody

Western blot analysis of FKBP52 in 3T3 cell lysate. Rabbit Purified Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FKBP4 antibody

Prostate  tissue was histologically stained with antibodies specific for FKBP52.  The strongest staining for FKBP52 is in ductal epithelial cells. Courtesy of David F. Smith, Mayo Clinic, USA. Mouse IgG1 Hi52C Purified Can, Hst, Hu, Ms, Rt IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FKBP4 antibody

Western blot analysis of extracts of various cell lines, using FKBP4 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

FKBP4 antibody

Prostate  tissue was histologically stained with antibodies specific for FKBP52.  The strongest staining for FKBP52 is in ductal epithelial cells. Courtesy of David F. Smith, Mayo Clinic, USA. Mouse IgG1 Hi52C Purified Can, Hst, Hu, Ms, Rt IP, P, WB
25 µg / €230.00
  Acris Antibodies GmbH

FKBP4 antibody

Western blot analysis of FKBP4 (arrow) using FKBP4 Antibody (Center) Cat.-No AP17384PU-N. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the FKBP4 gene. Rabbit Ig Purified Hu F, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

FKBP4 antibody

FKBP4 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

FKBP4 antibody

FKBP4 Rabbit Serum Hu, Ms E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

FKBP4 antibody

Cell lysates of HeLa ( 40 µg ) were resolved by SDS-PAGE, transferred to NC membrane and probed with FKBP4 monoclonal antibody, clone AT4D3 ( 1 : 1000 ). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG2b AT4D3 Hu E, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

FKBP4 antibody

Western blot analysis of Fkbp4 in NIH/3T3 cell lysate ( Lane 1 ) and rat kidney tissue lysate ( Lane 2 ) . Rabbit Hu, Ms, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

FKBP4 antibody

FKBP4 polyclonal antibody ( Cat # PAB11467 ) ( 0.01 µg/ml ) staining of human placenta lysate ( 35 µg protein in RIPA buffer ). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

FKBP4 antibody

Mouse Brain; . Sample Type: Mouse Brain Slices . Red: primary. Blue: DAPI. Primary. Dilution:.  1:400 . Secondary Antibody: Anti-Rabbit IgG Alexa 594. Secondary. Dilution:.  1:400 . Image Submitted By: Adahir Labrador-Garrido and Cintia Roodveldt . University of Seville. .; FKBP4 antibody - C-terminal region (ARP30180_P050) in Mouse Brain cells using Immunohistochemistry Rabbit Aff - Purified Hu, Por WB
50 µg / €350.00
  AVIVA Systems Biology

CRISPR

Catalog No. Species Donor Vector  

FKBP4 - human gene knockout kit via CRISPR

FKBP4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

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