FKBP4 antibody

Principal name

FKBP4 antibody

Alternative names for FKBP4 antibody

FK506-binding protein 4, FKBP52 protein, FKBP59, p59 protein, Peptidyl-prolyl cis-trans isomerase, PPIase, HSP-binding immunophilin, HBI, 52 kDa FK506-binding protein, Rotamase

SwissProt ID

P27124 (Rabit), P30416 (Mouse), Q02790 (Human), Q9QVC8 (Rat), Q9TRY0 (Bovin)

Gene ID

2288 (FKBP4), 14228 (Fkbp4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Hst (Hamster), Por (Porcine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), EPair for Elisa (EPair), Flow Cytometry (F)

Background of FKBP4 antibody

Hsp90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones (1). One class of Hsp90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an Hsp90 binding site. Among the TPR cochaperones of Hsp90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin Abinding families of immunophilins (2).
FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex (3).
The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the Hsp90 (4).
Although FKBP52 and FKBP51 share ~75% sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different Hsp90-binding characteristics (3, 5). Also, whereas FKBP51 typically has a role with the progesterone receptor, FKBP52 has been found to be linked to the progesterone, androgen and glucocorticoid receptors (5).

General readings

Ruan B, Pong K, Jow F, Bowlby M, Crozier RA, Liu D, Liang S, Chen Y, Mercado ML, Feng X, Bennett F, von Schack D, McDonald L, Zaleska MM, Wood A, Reinhart PH, Magolda RL, Skotnicki J, Pangalos MN, Koehn FE, Carter GT, Abou-Gharbia M, Graziani EI.
Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities.
Proc. Natl. Acad. Sci. U.S.A. 2008 Jan 105 (1): 33-8.
PMID: 18162540

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FKBP4 antibody

Immunohistochemistry: Paraffin embedded sections of Seminoma (Germ cell tumor) tissue were incubated with anti-human FKBP4 (1:50) for 2 hours at room temperature. Antigen retrieval was performed in 0.1M sodium citrate buffer and  Diaminobenzidine (DAB) was used for detection. Mouse IgG2b AT4D3 Purified Hu E, P, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

FKBP4 antibody

Immunohistochemistry: Paraffin embedded sections of Seminoma (Germ cell tumor) tissue were incubated with anti-human FKBP4 (1:50) for 2 hours at room temperature. Antigen retrieval was performed in 0.1M sodium citrate buffer and  Diaminobenzidine (DAB) was used for detection. Mouse IgG2b AT4D3 Purified Hu E, P, WB
50 µl / €230.00
  Acris Antibodies GmbH

FKBP4 antibody

  Rabbit Polyclonal antibody to FKBP52 (FK506 binding protein 4, 59kDa)  
FKBP4 antibody detects FKBP4 protein by Western blot analysis. A. 30 ug Rat2 whole cell lysate/extract. 10 % SDS-PAGE. FKBP4 antibody (TA308638) dilution: 1:1000 Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

FKBP4 (C-term) antibody

  Goat Anti-FKBP4 / FKBP52 Antibody  
TA305784 (0.01ug/ml) staining of Human Placenta lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FKBP4 antibody

  Rabbit polyclonal anti-FKBP52/Hsp56 antibody  
Western blot analysis of FKBP52 in 3T3 cell lysate. Rabbit Purified Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FKBP4 antibody

  Mouse monoclonal FKBP52 Antibody  
Prostate  tissue was histologically stained with antibodies specific for FKBP52.  The strongest staining for FKBP52 is in ductal epithelial cells. Courtesy of David F. Smith, Mayo Clinic, USA. Mouse IgG1 Hi52C Purified Can, Hst, Hu, Ms, Rt IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FKBP4 antibody

  Rabbit anti-FKBP4 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using FKBP4 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

FKBP4 antibody

Western blot analysis of FKBP4 (arrow) using FKBP4 Antibody (Center) Cat.-No AP17384PU-N. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the FKBP4 gene. Rabbit Ig Purified Hu F, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

FKBP4 - human gene knockout kit via CRISPR

FKBP4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

FKBP4 - human gene knockout kit via CRISPR

FKBP4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

FKBP4 - human gene knockout kit via CRISPR

FKBP4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

FKBP4 - human gene knockout kit via CRISPR

FKBP4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

FKBP4

  Recombinant protein of human FK506 binding protein 4, 59kDa (FKBP4)  
FKBP4 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

FKBP4 (1-459, His-tag)

FKBP4, 1-459aa human, His-tagged, recombinant, E.coli: 
15% SDS-PAGE (3 µg) Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €540.00
  Acris Antibodies GmbH

FKBP4 (1-459, His-tag)

FKBP4, 1-459aa human, His-tagged, recombinant, E.coli: 
15% SDS-PAGE (3 µg) Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €230.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

FKBP4 overexpression lysate

FKBP4 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, FKBP4 (mGFP-tagged) - Human FK506 binding protein 4, 59kDa (FKBP4), 200 uL, >10^7 TU/mL

Lenti ORF particles, FKBP4 (mGFP-tagged) - Human FK506 binding protein 4, 59kDa (FKBP4), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, FKBP4 (Myc-DDK tagged) - Human FK506 binding protein 4, 59kDa (FKBP4) , 200 uL, >10^7 TU/mL

Lenti ORF particles, FKBP4 (Myc-DDK tagged) - Human FK506 binding protein 4, 59kDa (FKBP4) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Fkbp4 (GFP-tagged) - Mouse FK506 binding protein 4 (Fkbp4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Fkbp4 (GFP-tagged) - Mouse FK506 binding protein 4 (Fkbp4), 200 uL, >10^7 TU/mL  
200 µl / €1,060.00
  OriGene Technologies, Inc.

Lenti ORF particles, Fkbp4 (Myc-DDK-tagged) - Mouse FK506 binding protein 4 (Fkbp4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Fkbp4 (Myc-DDK-tagged) - Mouse FK506 binding protein 4 (Fkbp4), 200 uL, >10^7 TU/mL  
200 µl / €950.00
  OriGene Technologies, Inc.

20 Item(s)

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