FKBP4 antibody

Principal name

FKBP4 antibody

Alternative names for FKBP4 antibody

FK506-binding protein 4, FKBP52 protein, FKBP59, p59 protein, Peptidyl-prolyl cis-trans isomerase, PPIase, HSP-binding immunophilin, HBI, 52 kDa FK506-binding protein, Rotamase

SwissProt ID

P27124 (Rabit), P30416 (Mouse), Q02790 (Human), Q9QVC8 (Rat), Q9TRY0 (Bovin)

Gene ID

2288 (FKBP4), 14228 (Fkbp4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Hst (Hamster), Por (Porcine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), EPair for Elisa (EPair), Flow Cytometry (F)

Background of FKBP4 antibody

Hsp90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones (1). One class of Hsp90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an Hsp90 binding site. Among the TPR cochaperones of Hsp90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin Abinding families of immunophilins (2).
FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex (3).
The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the Hsp90 (4).
Although FKBP52 and FKBP51 share ~75% sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different Hsp90-binding characteristics (3, 5). Also, whereas FKBP51 typically has a role with the progesterone receptor, FKBP52 has been found to be linked to the progesterone, androgen and glucocorticoid receptors (5).

General readings

Ruan B, Pong K, Jow F, Bowlby M, Crozier RA, Liu D, Liang S, Chen Y, Mercado ML, Feng X, Bennett F, von Schack D, McDonald L, Zaleska MM, Wood A, Reinhart PH, Magolda RL, Skotnicki J, Pangalos MN, Koehn FE, Carter GT, Abou-Gharbia M, Graziani EI.
Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities.
Proc. Natl. Acad. Sci. U.S.A. 2008 Jan 105 (1): 33-8.
PMID: 18162540

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FKBP4 antibody

  Mouse monoclonal FKBP52 Antibody  
Prostate  tissue was histologically stained with antibodies specific for FKBP52.  The strongest staining for FKBP52 is in ductal epithelial cells. Courtesy of David F. Smith, Mayo Clinic, USA. Mouse IgG1 Hi52C Purified Can, Hst, Hu, Ms, Rt IP, P, WB
0.1 mg / €430.00
  OriGene Technologies, Inc.

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