FKBP5 / FKBP51 antibody

Principal name

FKBP5 / FKBP51 antibody

Alternative names for FKBP5 / FKBP51 antibody

AIG6, FK506-binding protein 5, FKBP54, FF1 antigen, Rotamase, Peptidyl-prolyl cis-trans isomerase FKBP5, 51 kDa FK506-binding protein, 54 kDa progesterone receptor-associated immunophilin, HSP90-binding immunophilin, Androgen-regulated protein 6

SwissProt ID

Q13451 (Human), Q64378 (Mouse)

Gene ID

2289 (FKBP5), 14229 (Fkbp5)

Available reactivities

Hu (Human), Can (Canine), Hst (Hamster), Ms (Mouse), Rb (Rabbit), Rt (Rat), Bov (Bovine), Chk (Chicken), Por (Porcine), Ze (Zebrafish), African clawed frog, Eq (Equine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Paraffin Sections (P), EPair for Elisa (EPair)

Background of FKBP5 / FKBP51 antibody

Hsp90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones (1). One class of Hsp90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an Hsp90 binding site. Among the TPR cochaperones of Hsp90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin A-binding families of immunophilins (2).
FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex (3).
The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the Hsp90 (4). Although FKBP52 and FKBP51 share ~75% sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different Hsp90-binding characteristics (3).
FK506 binding protein 51 kDa (FKBP51 or otherwise referred to as FKBP54) has been identified as a progestininducible gene. This protein is predominantly expressed in murine T cells but in humans, it is abundantly expressed in numerous tissues at levels many times higher than FKBP12. The FKBP51 gene is known to be induced by glucocorticoids (5).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FKBP5 / FKBP51 antibody

  anti-FKBP5 (FKBP51) mouse monoclonal antibody, clone OTI3E9 (formerly 3E9)  
Immunohistochemical staining of paraffin-embedded colon tissue within the normal limits using anti-FKBP5mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500673, Dilution 1:50) Mouse IgG1 OTI3E9 Purified Hu ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

FKBP5 / FKBP51 antibody

  Mouse monoclonal FKBP51 Antibody  
Western blot analysis of FKBP51 in HeLa cell lysates, using a 1:1000 dilution of the antibody Mouse IgG Hi51B Purified Can, Hst, Hu, Ms, Rb, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FKBP5 / FKBP51 antibody

  Rabbit Polyclonal Anti-FKBP5 Antibody  
Host: Rabbit; Target Name: FKBP5; Sample Tissue: Thymus Tumor lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

FKBP5 / FKBP51 antibody

  Rabbit Polyclonal Anti-FKBP5 Antibody  
WB Suggested Anti-FKBP5 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

FKBP5 / FKBP51 antibody

  Rabbit Polyclonal FKBP51 Antibody  
WB was performed on whole cell lysates from mouse fibroblasts (NIH3T3) and embryonic stem cells (E14Tg2a) with the antibody against mouse FKBP51, diluted 1:500 in BSA/PBS-Tween. The molecular weight marker (in kDa) is shown on the left; the location of the protein of interest (expected size: 51 kDa) is indicated on the right. Rabbit IgG Purified Ms E
0.1 ml / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

FKBP5 - human gene knockout kit via CRISPR

FKBP5 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

FKBP5 - human gene knockout kit via CRISPR

FKBP5 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

FKBP5 - human gene knockout kit via CRISPR

FKBP5 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

FKBP5 - human gene knockout kit via CRISPR

FKBP5 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

FKBP5 / FKBP51 (transcript variant 1)

  Recombinant protein of human FK506 binding protein 5 (FKBP5), transcript variant 1  
FKBP5 / FKBP51 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

FKBP5 / FKBP51 (full length, N-term HIS tag, transcript variant 2)

  Purified recombinant protein of Human FK506 binding protein 5 (FKBP5), transcript variant 2, full length, with N-terminal HIS tag, expressed in E. coli, 50ug  
FKBP5 / FKBP51 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

FKBP5 overexpression lysate

FKBP5 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

FKBP5 overexpression lysate

FKBP5 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

FKBP5 overexpression lysate

FKBP5 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, FKBP5 (mGFP-tagged) - Human FK506 binding protein 5 (FKBP5), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, FKBP5 (mGFP-tagged) - Human FK506 binding protein 5 (FKBP5), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, FKBP5 (mGFP-tagged) - Human FK506 binding protein 5 (FKBP5), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, FKBP5 (mGFP-tagged) - Human FK506 binding protein 5 (FKBP5), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, FKBP5 (mGFP-tagged) - Human FK506 binding protein 5 (FKBP5), transcript variant 4, 200 uL, >10^7 TU/mL

Lenti ORF particles, FKBP5 (mGFP-tagged) - Human FK506 binding protein 5 (FKBP5), transcript variant 4, 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, FKBP5 (Myc-DDK tagged) - Human FK506 binding protein 5 (FKBP5), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, FKBP5 (Myc-DDK tagged) - Human FK506 binding protein 5 (FKBP5), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, FKBP5 (Myc-DDK tagged) - Human FK506 binding protein 5 (FKBP5), transcript variant 3 , 200 uL, >10^7 TU/mL

Lenti ORF particles, FKBP5 (Myc-DDK tagged) - Human FK506 binding protein 5 (FKBP5), transcript variant 3 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, FKBP5 (Myc-DDK tagged) - Human FK506 binding protein 5 (FKBP5), transcript variant 4 , 200 uL, >10^7 TU/mL

Lenti ORF particles, FKBP5 (Myc-DDK tagged) - Human FK506 binding protein 5 (FKBP5), transcript variant 4 , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

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