fMLP receptor antibody

Principal name

fMLP receptor antibody

Alternative names for fMLP receptor antibody

N-formyl peptide receptor, FPR1, fMet-Leu-Phe receptor, N-formylpeptide chemoattractant receptor

SwissProt ID

P21462 (Human), P33766 (Mouse), Q05394 (Rabit)

Gene ID

2357 (FPR1)

Available reactivities

Hu (Human), Chimp (Chimpanzee), Gorilla, Orang-Utan, Ms (Mouse), Rt (Rat), Prim (Primate), Mky (Monkey)

Available hosts

Rabbit

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of fMLP receptor antibody

Chemotactic factors from both Gram-positive and Gram-negative bacteria are short peptides with N-formyl methionine at the N-terminus (extensively reviewed in reference 1). These peptides are released from bacteria during infection and activate formyl peptide receptor (FPR), a member of G-protein coupled receptors (GPCRs). In humans, the FPR family consists mainly of three receptors, FPR1, FPR2/ALX (formerly FPRL1), and FPR3 (formerly FPRL2) which all couple to the Gi subtype of G-proteins and ultimately lead to the activation of phospholipase C and intracellular Ca2+ increase. FPRL1 or FPR2/ALX as commonly called is a seven transmembrane protein like all GPCRs. This receptor was origilly cloned by screening a HL60 neutrophil cD library with a FPR1 cD probe. FPR2/ALX shares 69% identity with FPR1 and despite its high homology, it displays relatively low affinity for fmlf, the most potent N-formyl peptide released by bacteria. FPR1 was origilly found in neutrophils and later found to be distributed in myeloid and non-myeloid cells as is the case for FPR2/ALX and FPR3 (FPR3 though is not expressed in neutrophils). FPR1 is also expressed in multiple organs and tissues including epithelial cells in organs with secretory functions, endocrine cells, liver hepathocytes, smooth muscle cells and endothelial cells, brain spil cord and both motor and sensory neurons. FPR2/ALX has a similar tissue distribution to that of FPR1. While N-formyl peptides were the first peptides found to activate these receptors, the ligand diversity for FPR has proven to be quite broad and demonstrates to be both pro- and anti-inflammatory. They include peptidic ligands origiting from bacterial and viral sources (including HIV), endogenous ligands such as chemokines and annexins, short peptides associated with inflammation and infection. Indeed, peptides from Herpes, Ebola and corovirus 229E are ligands of FPR1.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

fMLP receptor antibody

Western blot analysis of extracts from K562 cells, using FPR1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

fMLP receptor antibody

Immunofluorescence analysis of A549 cells, using FPR1 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, ICC/IF
0.1 ml / €325.00
  OriGene Technologies, Inc.

fMLP receptor antibody

Western blot analysis of human HL-60 promyelocytic leukemia (lanes 1 and 4), human THP-1 acute monocytic leukemia (lanes 2 and 6), human T-84 colorectal carcinoma (lanes 3 and 7) and human U-87 MG glioblastoma (lanes 4 and 8) cell lysates: 1-4. Anti-Human FPR1 (extracellular) antibody, (1:200). 5-8. Anti-Human FPR1 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

fMLP receptor antibody

Western Blot: FPR1 Antibody [TA336365] - Western blot analysis of FPR1 in the 1) absence and 2) presence of immunizing peptide in human liver lysate using TA336365 at 1 ug/ml. Rabbit Purified Hu, Prim WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

fMLP receptor (3rd extracel. dom.) antibody

Anti-FPR1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Mky, Prim P
50 µg / €379.00
  OriGene Technologies, Inc.

fMLP receptor antibody

Anti-FPR1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

fMLP receptor (3rd extracel. dom.) antibody

Anti-FPR1 antibody IHC of human spleen, red pulp. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Prim P
50 µg / €379.00
  OriGene Technologies, Inc.

fMLP receptor antibody

Anti-FPR1 antibody IHC of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Mky
50 µg / €379.00
  OriGene Technologies, Inc.

fMLP receptor (176-190) antibody

Small intestine: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Prim P, WB
50 µg / €470.00
  Acris Antibodies GmbH

fMLP receptor antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

fMLP receptor antibody

Western blot analysis of FPR1 in the 1 ) absence and 2 ) presence of immunizing peptide in human liver lysate. Using FPR1 polyclonal antibody ( Cat # PAB0284 ) at 1 µg/ml. Rabbit Chimp, Gorilla, Hu WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

fMLP receptor antibody

Immunofluorescence analysis of MCF7 cells, using FPR1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, WB
50 µg / €205.00
  Assay Biotech

fMLP receptor antibody

Immunofluorescence analysis of MCF7 cells, using FPR1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €310.00
  Assay Biotech

fMLP receptor antibody

Immunofluorescence analysis of A549 cells, using FPR1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF
50 µg / €205.00
  Assay Biotech

fMLP receptor antibody

Immunofluorescence analysis of A549 cells, using FPR1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF
0.1 mg / €310.00
  Assay Biotech

fMLP receptor antibody

Immunohistochemical analysis of FPR1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

fMLP receptor antibody

Immunohistochemical analysis of FPR1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

fMLP receptor antibody

Immunohistochemical analysis of FPR1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

fMLP receptor antibody

Western blot analysis of FPR1 expression in A549 (A); Raw264.7 (B); rat brain (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

fMLP receptor antibody

Western blot analysis of FPR1 expression in A549 (A); Raw264.7 (B); rat brain (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

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