FMO3 antibody

Principal name

FMO3 antibody

Alternative names for FMO3 antibody

FMO form 2, FMO II, Dimethylaniline oxidase 3, Dimethylaniline monooxygenase [N-oxide-forming] 3, Hepatic flavin-containing monooxygenase 3

SwissProt ID

P31513 (Human), P32417 (Rabit), P97501 (Mouse), Q8HYJ9 (Bovin), Q95LA1 (Canfa), Q9EQ76 (Rat)

Gene ID

2328 (FMO3), 14262 (Fmo3), 84493

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rb (Rabbit), Rt (Rat), African clawed frog, GP (Guinea Pig), Gt (Goat), Ye (Yeast), Por (Porcine)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Paraffin Sections (P)

Background of FMO3 antibody

Flavin-containing monooxygeses (FMO) are an important class of drug-metabolizing enzymes that catalyze the DPH-dependent oxygetion of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Altertive splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.

General readings

Akerman, B. R., Chow, L., Forrest, S., Youil, R., Cashman, J., Treacy, E. P. Mutations in the
flavin-containing monoxygenase (sic) form 3 (FMO3) gene cause trimethylaminuria, fish odour
syndrome. (Abstract) Am. J. Hum. Genet. 61 (suppl.): A53 only, 1997.
2. Cashman, J. R., Zhang, J. Interindividual differences of human flavin-containing monooxygenase 3:
genetic polymorphisms and functional variation. Drug Metab. Dispos. 30: 1043-1052, 2002.
3. Dolphin, C. T., Janmohamed, A., Smith, R. L., Shephard, E. A., Phillips, I. R. Missense mutation in
flavin-containing mono-oxygenase 3 gene, FMO3, underlies fish-odour syndrome. Nature Genet. 17:
491-494, 1997.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FMO3 antibody

  Rabbit anti-FMO3 Polyclonal Antibody  
Western blot analysis of extracts of mouse liver cell lines, using FMO3 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

FMO3 antibody

  Rabbit Polyclonal Anti-FMO3 Antibody  
WB Suggested Anti-FMO3 Antibody Titration: 0.2-1 ug/ml; Positive Control: OVCAR-3 cell lysate.FMO3 is strongly supported by BioGPS gene expression data to be expressed in Human OVCAR3 cells Rabbit IgG Purified Bov, GP, Gt, Hu, Ms, Rt, Ye WB
50 µg / €325.00
  OriGene Technologies, Inc.

FMO3 antibody

  Rabbit Polyclonal Anti-FMO3 Antibody  
WB Suggested Anti-FMO3 Antibody Titration: 0.2-1 ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

FMO3 (Center) antibody

  Rabbit Polyclonal Anti-Fmo3 Antibody  
Mouse Heart; WB Suggested Anti-Fmo3 Antibody. . Titration: 1.0 ug/ml. . Positive Control: Mouse Heart; Fmo3 antibody - middle region (AP46032PU-N) in Mouse Heart cells using Western Blot Rabbit Aff - Purified Hu, Ms WB
50 µg / €325.00
  OriGene Technologies, Inc.

FMO3 antibody

  FMO3 mouse monoclonal antibody, clone OTI3H1 (formerly 3H1)  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-FMO3 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA808310)(1:150) Mouse IgG1 OTI3H1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FMO3 (N-term) antibody

Western blot analysis of FMO3 Antibody (N-term) (AP17395PU-N) in MDA-MB231 cell line lysates (35 µg/lane). FMO3 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

FMO3 - human gene knockout kit via CRISPR

FMO3 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

FMO3 - human gene knockout kit via CRISPR

FMO3 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

FMO3 - human gene knockout kit via CRISPR

FMO3 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

FMO3 - human gene knockout kit via CRISPR

FMO3 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Fmo3 - mouse gene knockout kit via CRISPR

Fmo3 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Fmo3 - mouse gene knockout kit via CRISPR

Fmo3 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Fmo3 - mouse gene knockout kit via CRISPR

Fmo3 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Fmo3 - mouse gene knockout kit via CRISPR

Fmo3 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

FMO3 (transcript variant 1)

  Recombinant protein of human flavin containing monooxygenase 3 (FMO3), transcript variant 1  
FMO3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

FMO3 (transcript variant 2)

  Recombinant protein of human flavin containing monooxygenase 3 (FMO3), transcript variant 2  
FMO3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, FMO3 (mGFP-tagged) - Human flavin containing monooxygenase 3 (FMO3), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, FMO3 (mGFP-tagged) - Human flavin containing monooxygenase 3 (FMO3), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,160.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Fmo3 (GFP-tagged) - Mouse flavin containing monooxygenase 3 (Fmo3), 200 uL, >10^7 TU/mL

Lenti ORF particles, Fmo3 (GFP-tagged) - Mouse flavin containing monooxygenase 3 (Fmo3), 200 uL, >10^7 TU/mL  
200 µl / €1,160.00
  OriGene Technologies, Inc.

Lenti ORF particles, Fmo3 (Myc-DDK-tagged) - Mouse flavin containing monooxygenase 3 (Fmo3), 200 uL, >10^7 TU/mL

Lenti ORF particles, Fmo3 (Myc-DDK-tagged) - Mouse flavin containing monooxygenase 3 (Fmo3), 200 uL, >10^7 TU/mL  
200 µl / €1,040.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Fmo3 (GFP-tagged ORF) - Rat flavin containing monooxygenase 3 (Fmo3), 200 uL, >10^7 TU/mL

Lenti ORF particles, Fmo3 (GFP-tagged ORF) - Rat flavin containing monooxygenase 3 (Fmo3), 200 uL, >10^7 TU/mL  
200 µl / €1,160.00
  OriGene Technologies, Inc.

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