FNBP1L antibody

Principal name

FNBP1L antibody

Alternative names for FNBP1L antibody

C1orf39, TOCA1, Formin-binding protein 1-like, Transducer of Cdc42-dependent actin assembly protein 1

SwissProt ID

Q2HWF0 (Rat), Q5T0N5 (Human), Q6DCZ7 (Xenla), Q8K012 (Mouse)

Gene ID

54874 (FNBP1L), 214459 (Fnbp1l), 310839

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of FNBP1L antibody

Actin reorganization is important for the regulation of neuronal morphology. A protein involved in this process, the transducer of cdc42-dependent actin assembly 1 (TOCA-1) protein, a member of the evolutionarily conserved pombe CDC15 homology (PCH) protein family, is an essential component of the Cdc42 pathway. TOCA-1 binds both N-WASP and Cdc42 and is essential for Cdc42- and PIP2-induced actin polymerization, suggesting that TOCA-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Decreased expression of TOCA-1 significantly enhances neurite elongation in PC-12 cells; its overexpression in the same cells suppresses neurite elongation. It has been suggested that TOCA-1 negatively regulates axon branching by regulating membrane trafficking by regulating membrane trafficking through the F-BAR/EFC domain. Multiple isoforms of TOCA-1 are known to exist.

General readings

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010)
Bu, W., et al. PLoS ONE 5 (8), E12153 (2010)
Bu, W., et al. J. Biol. Chem. 284(17):11622-11636(2009)
Huett, A., et al. J. Immunol. 182(8):4917-4930(2009)
Leung, Y., et al. Cell Host Microbe 3(1):39-47(2008)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FNBP1L (C-term) antibody

  Rabbit Polyclonal TOCA-1 Antibody  
Western blot analysis of TOCA-1 in mouse brain tissue lysate with in (A) the absence and (B) the presence of blocking peptide with TOCA-1 antibody at 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FNBP1L (N-term) antibody

  Rabbit Polyclonal TOCA-1 Antibody  
Western blot analysis of TOCA-1 in human brain tissue lysate in (A) the absence and (B) the presence of blocking peptide with TOCA-1 antibody at 0.5 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FNBP1L (C-term) antibody

Human Kidney (formalin-fixed, paraffin-embedded) stained with FNBP1L antibody AP22666PU-N at 2.5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

FNBP1L (Center) antibody

Western blot analysis of FNBP1L Antibody Cat.-No AP51691PU-N in mouse lung tissue lysates (35ug/lane). This demonstrates the FNBP1L antibody detected the FNBP1L protein (arrow). Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

FNBP1L antibody

FNBP1L Mouse IgG2a 1E6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

FNBP1L antibody

Immunohistochemistry of FNBP1L in human brain tissue with FNBP1L polyclonal antibody ( Cat # PAB13309 ) at 2.5 µg/ml. Rabbit Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

FNBP1L antibody

Immunohistochemical staining of human brain tissue using FNBP1L polyclonal antibody ( Cat # PAB13310 ) at 2.5 µg/ml. Rabbit Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

CRISPR

Catalog No. Species Donor Vector  

FNBP1L - human gene knockout kit via CRISPR

FNBP1L - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

FNBP1L - human gene knockout kit via CRISPR

FNBP1L - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

FNBP1L - human gene knockout kit via CRISPR

FNBP1L - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

FNBP1L - human gene knockout kit via CRISPR

FNBP1L - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Fnbp1l - mouse gene knockout kit via CRISPR

Fnbp1l - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Fnbp1l - mouse gene knockout kit via CRISPR

Fnbp1l - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Fnbp1l - mouse gene knockout kit via CRISPR

Fnbp1l - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Fnbp1l - mouse gene knockout kit via CRISPR

Fnbp1l - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

FNBP1L

FNBP1L Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

FNBP1L

FNBP1L Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, FNBP1L (mGFP-tagged)-Human formin binding protein 1-like (FNBP1L), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, FNBP1L (mGFP-tagged)-Human formin binding protein 1-like (FNBP1L), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

Lenti ORF particles, FNBP1L (mGFP-tagged)-Human formin binding protein 1-like (FNBP1L), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, FNBP1L (mGFP-tagged)-Human formin binding protein 1-like (FNBP1L), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

Lenti ORF particles, FNBP1L (mGFP-tagged)-Human formin binding protein 1-like (FNBP1L), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, FNBP1L (mGFP-tagged)-Human formin binding protein 1-like (FNBP1L), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,260.00
  OriGene Technologies, Inc.

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