FNTB antibody

Principal name

FNTB antibody

Alternative names for FNTB antibody

FTase-beta, CAAX farnesyltransferase subunit beta, Protein farnesyltransferase subunit beta, Ras proteins prenyltransferase subunit beta

SwissProt ID

P49355 (Bovin), P49356 (Human), Q02293 (Rat), Q8K2I1 (Mouse)

Gene ID

2342 (FNTB), 64511 (Fntb)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Immunoprecipitation (IP), Paraffin Sections (P), Western blot / Immunoblot (WB)

Background of FNTB antibody

Eukaryotic cells contain 3 different types of prenyltransferases that attach either a farnesyl group (15 carbons) or a geranylgeranyl group (20 carbons) in thioether linkage to C-terminal cysteine residues in a variety of proteins. These posttranslational modifications provide a mechanism for membrane localization of proteins that lack a transmembrane domain. CAAX farnesyltransferase (FTase) attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the CAAX box, where C is cysteine, A is usually but not always an aliphatic amino acid, and X is typically methionine or serine. This enzyme has the ability to farnesylate peptides as short as 4 residues in length that conform to the CAAX consensus sequence. The gene for the beta subunit of CAAX farnesyltransferase (FNTB) has been pinpointed to 14q23-q24 by Southern blot hybridization and PCR analyses of panels of human/Chinese hamster somatic cell hybrid lines and by fluorescence chromosomal in situ hybridization.

General readings

Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009)
Fontaine-Bisson, B., et al. J. Mol. Med. (2009) In press.
Zhou, J., et al. J. Biol. Chem. 284(15):9648-9655(2009)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FNTB antibody

Western blot analysis of extracts from 3T3 cells and RAW264.7 cells, using FNTB antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

FNTB antibody

WB Suggested Anti-Fntb Antibody; Titration: 1.0 ug/ml; Positive Control: Rat Thymus Rabbit IgG Purified Hu, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

FNTB antibody

Western blot (WB) analysis of FTβ antibody (Cat.-No.: AP01497PU-N) in extracts from RAW264.7 cells. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €350.00
  Acris Antibodies GmbH

FNTB (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

FNTB (N-term) antibody

Western blot analysis of FNTB Antibody (N-term) (Cat.-No AP51695PU-N in CEM cell line lysates (35ug/lane). This demonstrates the FNTB antibody detected the FNTB protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

FNTB antibody

Detection limit for recombinant GST tagged FNTB is approximately 3ng/ml as a capture antibody. Mouse IgG2b 3A9 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

FNTB antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with FNTB polyclonal antibody ( Cat # PAB4316 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . BC = breast carcinoma . Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

FNTB antibody

Western blot analysis of extracts from RAW264.7/NIH-3T3 cells, using FNTB Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €205.00
  Assay Biotech

FNTB antibody

Western blot analysis of extracts from RAW264.7/NIH-3T3 cells, using FNTB Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €310.00
  Assay Biotech

FNTB antibody

Western blot analysis of FNTB expression in K562 (A); A431 (B); Raw264.7 (C); PC12 (D) whole cell lysates. Rabbit Aff - Purified Bov, Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

FNTB antibody

Western blot analysis of FNTB expression in K562 (A); A431 (B); Raw264.7 (C); PC12 (D) whole cell lysates. Rabbit Aff - Purified Bov, Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

FNTB antibody

Western blot analysis of FNTB expression in K562 (A); A431 (B); Raw264.7 (C); PC12 (D) whole cell lysates. Rabbit Aff - Purified Bov, Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

FNTB antibody

FNTB Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €420.00
  Novus Biologicals Inc.

FNTB antibody

FNTB Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

FNTB antibody

FNTB Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
50 µg / €290.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

FNTB

FNTB Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

FNTB

FNTB Human in vitro transl.
2 µg / €300.00
  Abnova Taiwan Corp.

FNTB

FNTB Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

FNTB

FNTB Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

19 Item(s)

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