Follicle-stimulating hormone / FSH antibody

Principal name

Follicle-stimulating hormone / FSH antibody

Alternative names for Follicle-stimulating hormone / FSH antibody

Follitropin beta chain, FSHB, FSH beta

SwissProt ID

P01225 (Human), P01226 (Horse), P01227 (Sheep), P01228 (Pig), P04837 (Bovin), P18427 (Rat), Q60687 (Mouse), Q6IY73 (Rabit), Q9JK69 (Cavpo)

Gene ID

2488 (FSHB), 25447 (Fshb), 14308, 443387, 281171

Available reactivities

Hu (Human), Bov (Bovine), Rt (Rat), Ms (Mouse), Sh (Sheep)

Available hosts

Mouse, Rabbit, Guinea Pig, Sheep, Goat

Available applications

Enzyme Immunoassay (E), ELISA capture and detection (E(caption)/E(detection)), ELISA (detection) (E(detection)), ELISA (capture) (E(capture)), Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Radioimmunoassay (R), Dot blot (Dot), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Luminex (LMNX)

Background of Follicle-stimulating hormone / FSH antibody

The pituitary hormones, luteinizing hormone (lutropin, LH) and follicle stimulating hormone (follitropin, FSH) as well as related placental hormones, chorionic gonadotropin and CG, are referred to as gonadotropic hormones because of their action on gonad cells. These three hormones are structurally related to each other as well as to thyroid stimulating hormone (TSH). Because of their similar structure and composition and glycoprotein nature, LH, TSH, GC and FSH, these hormones are referred to as glycoprotein hormones. All these hormones are heterodimeric in nature composed of two un-identical subunits, alpha and beta which are non-covalently associated, Among humans and other species, the Alpha subunit is identical for all these hormones and is coded by a single gene, where is beta subunits are distinct but homologous and arise from separate genes. The individual hormone subunits and peptides derived from them have shown some binding activities to their respective receptors, the association of alpha and beta subunits clearly is required for optimal activation and physiological responses elicited by these hormones. Within the heterodimeric hormones, the beta subunit confors the binding activity to its respective receptor. The LH and CG beta subunits have 85% sequence identity in their first 114 amino acids, the LH/CG receptors can recognize either of the pituitary LH or placental CG hormones.
The alpha and beta subunits of LH, CG and FSH are highly glycosylated (1). The alpha subunit has two N-linked oligosdaccharide chain at position 52 and 78 and beta subunits have one in LH and TSH and two in CG and FSH. The CG beta subunit also has an extension of serine O-linked carbohydrates at carboxyl end which help is plasma half like of CG compared to other glycohormone beta subunits. The N-linked oligosaccharides on FSH are sialylated whereas LH and TSH are sialylated and sulfated. There are 10-12 cysteins forming 3 disulfide bonds referred to as “cystine knots” in each of the beta subunits of these hormones which are conserved in various species. Adenohypophyseal gonadotroph cells synthesize and secrete LH and FSH under independent regulatory controls and their release by pituitary is positively regulated by hypothalamic decapeptide gonadotropin releasing hormone (GnRH) and is negatively regulated by feedback effects of gonadal steroids and gonadal, peptide inhibin, a peptide produced in testis and ovaries in response to FSH (2). Both males and females synthesize and secrete FSH and LH by gonadotrope cells of the anterior pituitary. In females progesterone and estrogen inhibit LH and FSH release. The action of LH and CG are carried out by LH/CG receptors and FSH effects are by independent FSH receptors with GPCR associated 7TMDs.

General readings

1. Kim, M.N. et al. (2008) Changes in the reproductive function and developmental phenotypes in mice following intramuscular injection of an activin betaA-expressing plasmid.
Reprod Biol Endocrinol. 6: 63.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Follicle-stimulating hormone / FSH antibody

Anti-FSHB mouse monoclonal antibody (TA501603) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY FSHB(RC214616). Mouse IgG1 OTI3A9 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Follicle-stimulating hormone / FSH antibody

FSHB ELISA with 4E8 Capture (TA600097) and 2A6 Detection (TA700094) Antibodies. Substrate used: Recombinant Human FSHB (TP322666) Mouse IgG1 OTI4E8 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

Follicle-stimulating hormone / FSH antibody

FSHB ELISA with 4E10 Capture (TA600096) and 2E5 Detection (TA700095) Antibodies. Substrate used: Recombinant Human FSHB (TP322666) Mouse IgG1 OTI2E5 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

Follicle-stimulating hormone / FSH antibody

Immunohistochemistry staining of Paraffin Pituitary tissue by FSH antibody (dilution: 1:25 - 1:100; visualization of staining: Cytoplasmic) Rabbit Purified Hu P
1 ml / €250.00
  OriGene Technologies, Inc.

Follicle-stimulating hormone / FSH antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FSHB (RC214616, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FSHB. Mouse IgG2b OTI4D12 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Follicle-stimulating hormone / FSH antibody

Anti-FSHB mouse monoclonal antibody (TA501581) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY FSHB(RC214616). Mouse IgG1 OTI2A6 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Follicle-stimulating hormone / FSH antibody

Anti-FSHB mouse monoclonal antibody (TA501582) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY FSHB(RC214616). Mouse IgG1 OTI2G9 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Follicle-stimulating hormone / FSH antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FSHB (RC214616, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FSHB. Mouse IgG2a OTI1B2 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Follicle-stimulating hormone / FSH antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FSHB (RC214616, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FSHB. Mouse IgG2a OTI2E5 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Follicle-stimulating hormone / FSH antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FSHB (RC214616, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FSHB. Mouse IgG1 OTI4E10 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Follicle-stimulating hormone / FSH antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FSHB (RC214616, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FSHB. Mouse IgG1 OTI4E8 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Follicle-stimulating hormone / FSH antibody

Anti-FSHB mouse monoclonal antibody (TA501646) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY FSHB(RC214616). Mouse IgG1 OTI4B9 Purified Hu F, ICC/IF, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Follicle-stimulating hormone / FSH antibody

FSHB ELISA with 1B2 Capture (TA600094) and 4E10 Detection (TA700097) Antibodies. Substrate used: Recombinant Human FSHB (TP322666) Mouse IgG1 OTI1B2 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

Follicle-stimulating hormone / FSH antibody

FSHB ELISA with 2E5 Capture (TA600095) and 4E8 Detection (TA700133) Antibodies. Substrate used: Recombinant Human FSHB (TP322666) Mouse IgG1 OTI2E5 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

Follicle-stimulating hormone / FSH antibody

FSHB ELISA with 4E10 Capture (TA600096) and 2E5 Detection (TA700095) Antibodies. Substrate used: Recombinant Human FSHB (TP322666) Mouse IgG1 OTI4E10 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

Follicle-stimulating hormone / FSH antibody

FSHB ELISA with 4E8 Capture (TA600097) and 2A6 Detection (TA700094) Antibodies. Substrate used: Recombinant Human FSHB (TP322666) Mouse IgG1 OTI2A6 Purified Hu E
50 µg / €345.00
  OriGene Technologies, Inc.

Follicle-stimulating hormone / FSH antibody

FSHB ELISA with 4E8 Capture (TA600097) and 3A9 Detection (TA700096) Antibodies. Substrate used: Recombinant Human FSHB (TP322666) Mouse IgG1 OTI3A9 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

Follicle-stimulating hormone / FSH antibody

FSHB ELISA with 1B2 Capture (TA600094) and 4E10 Detection (TA700097) Antibodies. Substrate used: Recombinant Human FSHB (TP322666) Mouse IgG1 OTI4E10 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

Follicle-stimulating hormone / FSH antibody

FSHB ELISA with 2E5 Capture (TA600095) and 4E8 Detection (TA700133) Antibodies. Substrate used: Recombinant Human FSHB (TP322666) Mouse IgG1 OTI4E8 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

Follicle-stimulating hormone / FSH (beta) antibody

Follicle-stimulating hormone / FSH Mouse IgG B251M Purified Hu E, WB
1 mg / €480.00
  Acris Antibodies GmbH

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