FOLR4 / FOLBP3 antibody

Principal name

FOLR4 / FOLBP3 antibody

Alternative names for FOLR4 / FOLBP3 antibody

Folate receptor 4, Folate-binding protein 3, Probable folate receptor delta

SwissProt ID

A6ND01 (Human), Q9EQF4 (Mouse)

Gene ID

390243 (FOLR4), 64931 (Folr4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Rat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Flow Cytometry (F)

Background of FOLR4 / FOLBP3 antibody

Folates represent an important role in protein and nucleic acid biosynthesis and are recognized in particular for their role in spinal canal and brain development during early pregnancy. Recently, Yamaguchi et al, 2007 have shown that Folate receptor 4 (FR4), a subtype of the receptor for the vitamin folic acid is expressed at high levels in both natural and TGF-b-induced Treg cells. A majority of the CD4+ Tregs express FR4 along with CD25 and FoxP3. In addition, there are functional similarities in regulating immune response by FoxP3 and FR4 expressing CD4+ Tregs which express CD25 as well. CD4+CD25+FR4hi T cell population may be used as a functional immuno-suppressor Treg population which should express FoxP3. FR4 may be considered as a cell surface marker for Tregs. The antibodies produced by clones 12A5 and TH6 recognize FR4 in Tregs. FR4 is also known as folate receptor delta and folate-binding protein 3. The FR4 antibodies in combination with CD4 and CD25 antibodies may be used for isolation (both FACS and magnetic beads sorting) and staining of Tregs using simple surface staining while keeping the Tregs viable for subsequent down stream applications. FR4 is known to be expressed exclusively in lymphoid tissues.

General readings

1. Spiegelstein O, Eudy JD, Finnell RH. Identification of two putative novel folate receptor genes in humans and mouse. Gene. 2000 Nov 27;258(1-2):117-25. PubMed PMID: 11111049.
2. Elnakat H, Ratnam M. Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy. Adv Drug Deliv Rev. 2004 Apr 29;56(8):1067-84. PubMed PMID: 15094207.
3. Yamaguchi T, Hirota K, Nagahama K, Ohkawa K, Takahashi T, Nomura T, et al. Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor. Immunity. 2007 Jul;27(1):145-59. Epub 2007 Jul 5. PubMed PMID: 17613255.
4. Walker LS. Regulatory T cells: Folate receptor 4: a new handle on regulation and memory? Immunol Cell Biol. 2007 Oct;85(7):506-7. Epub 2007 Aug 21. PubMed PMID: 17710105.

6 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FOLR4 / FOLBP3 antibody

FOLR4 / FOLBP3 Rat IgG2b TH6 Azide Free Ms F
0.1 mg / €380.00
  Acris Antibodies GmbH

FOLR4 / FOLBP3 antibody

FOLR4 / FOLBP3 Rat IgG2b TH6 Biotin Ms F
50 µg / €410.00
  Acris Antibodies GmbH

FOLR4 / FOLBP3 antibody

Flow Cytometric analysis of Mouse FR4 expression on Mouse splenic CD4+ T cells. Rat IgG2b TH6 FITC Ms F
50 µg / €410.00
  Acris Antibodies GmbH

FOLR4 / FOLBP3 antibody

FOLR4 / FOLBP3 Rat IgG2b TH6 PE Ms F
50 Tests / €410.00
  Acris Antibodies GmbH

FOLR4 / FOLBP3 (N-term) antibody

Western blot analysis of FOLR4 Antibody (N-term) Cat.-No AP51698PU-N in 293 cell line lysates (35ug/lane). This demonstrates the FOLR4 antibody detected the FOLR4 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

FOLR4 / FOLBP3 antibody

FOLR4 / FOLBP3 Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

6 Item(s)

per page
  • LinkedIn