FOXA1 / TCF3A antibody

Principal name

FOXA1 / TCF3A antibody

Alternative names for FOXA1 / TCF3A antibody

Forkhead box protein A1, HNF3A, HNF-3A, HNF-3-alpha, TCF-3A, Hepatocyte nuclear factor 3-alpha, Transcription factor 3A

SwissProt ID

P23512 (Rat), P35582 (Mouse), P55317 (Human)

Gene ID

3169 (FOXA1), 15375 (Foxa1), 25098

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Chk (Chicken), Bt (Bat), Fi (Fish), Hst (Hamster), Mky (Monkey), Op (Opossum), Por (Porcine), Prim (Primate), Xen (Xenopus), L (Lizard), Bear, GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), ChIP assay (ChIP)

Background of FOXA1 / TCF3A antibody

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.

General readings

Hu, D.G., et al. Mol. Pharmacol. 78(4):714-722(2010)
Zhang, Y., et al. J. Biol. Chem. 285(37):28604-28613(2010)
Bernardo, G.M., et al. Development 137(12):2045-2054(2010)
Liu, N., et al. Zhonghua Yi Xue Za Zhi 90(20):1403-1407(2010)
Song, Y., et al. Cancer Res. 70(5):2115-2125(2010)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FOXA1 / TCF3A antibody

  FOXA1 mouse monoclonal antibody, clone OTI3C1 (formerly 3C1)  
FOXA1 / TCF3A Mouse IgG2b OTI3C1 Purified Can, Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

FOXA1 / TCF3A antibody

  Rabbit Polyclonal FOXA1 Antibody  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-FOXA1 Rabbit Polyclonal antibody. (TA590183) Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FOXA1 / TCF3A (367-473) antibody

Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2b 4F6 Purified Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

FOXA1 / TCF3A antibody

Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 2D7 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

FOXA1 / TCF3A (367-473) antibody

Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 1B1 Purified Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

FOXA1 / TCF3A (367-473) antibody

Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 3C1 Purified Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

FOXA1 / TCF3A (C-term) antibody

  Goat Polyclonal Antibody against FOXA1 / HNF3A  
TA302660 (0.3µl/ml) staining  of HepG2 cell lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Bov, Hu, Ms, Por, Rt ChIP, E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FOXA1 / TCF3A antibody

  Rabbit Polyclonal FOXA1 Antibody  
Western blot analysis of FOXA1 in 293 cell lysate with FOXA1 antibody at 1 ug/mL Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FOXA1 / TCF3A antibody

  Rabbit Polyclonal Anti-FOXA1 Antibody  
Sample Type: 1. Control (20ug); 2. shRNA1-FOXA1 H9 hES cells (20ug); 3. shRNA2-FOXA1 H9 hES cells (20ug); Primary Dilution: 1: 1000; Secondary Antibody: anti-Rabbit HRP; Secondary Dilution: 1: 5000; Image Submitted By: Jingli Cai; Thomas Jefferson Univers Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

FOXA1 / TCF3A antibody

  Rabbit Polyclonal Anti-FOXA1 Antibody - N-terminal region  
WB Suggested Anti-FOXA1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: HepG2 cell lysateFOXA1 is supported by BioGPS gene expression data to be expressed in HepG2 Rabbit IgG Purified Bov, Can, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

FOXA1 / TCF3A antibody

  anti-FOXA1 mouse monoclonal antibody, clone OTI3A8 (formerly 3A8)  
Anti-FOXA1 mouse monoclonal antibody (TA500245) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY FOXA1(RC206045). Mouse IgG2b OTI3A8 Purified Can, Hu ICC/IF, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

FOXA1 / TCF3A (429-439) antibody

Human Prostate (formalin-fixed, paraffin-embedded) stained with FOXA1 antibody AP22568PU-N followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Bear, Bov, Bt, Elephant, Fi, Hst, Hu, L, Mky, Ms, Op, Por, Prim, Rt, Xen E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

FOXA1 / TCF3A (Center) antibody

Western blot analysis of FOXA1 / TCF3A Antibody (Center) Cat.-No AP51701PU-N in 293 cell line lysates (35ug/lane). This demonstrates the FOXA1 antibody detected the FOXA1 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

FOXA1 - human gene knockout kit via CRISPR

FOXA1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

FOXA1 - human gene knockout kit via CRISPR

FOXA1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

FOXA1 - human gene knockout kit via CRISPR

FOXA1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

FOXA1 - human gene knockout kit via CRISPR

FOXA1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Foxa1 - mouse gene knockout kit via CRISPR

Foxa1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Foxa1 - mouse gene knockout kit via CRISPR

Foxa1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Foxa1 - mouse gene knockout kit via CRISPR

Foxa1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

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