FOXO1A antibody

Principal name

FOXO1A antibody

Alternative names for FOXO1A antibody

Forkhead Box Protein O1, FOXO1, FKHR, Forkhead Box Protein O1A, Forkhead in Rhabdomyosarcoma

SwissProt ID

Q12778 (Human), Q9R1E0 (Mouse)

Gene ID

2308 (FOXO1)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Por (Porcine), Ms (Mouse), Rt (Rat), Chk (Chicken), Ze (Zebrafish), African clawed frog, Bt (Bat), Eq (Equine), Hst (Hamster), Mky (Monkey), Op (Opossum), Prim (Primate), Rb (Rabbit), Tr (Turkey), Bear

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), ChIP assay (ChIP)

Background of FOXO1A antibody

Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts syngernistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A to activate the expression of genes such as IGFBP1, G6PC and PPCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells.

General readings

1. Xiao N  et al. The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells. Nat Immunol 15:657-66 (2014).
2. Chen C  et al. High cytoplasmic FOXO1 and pFOXO1 expression in astrocytomas are associated with worse surgical outcome. PLoS One 8:e69260 (2013). IHC .
3. Kibbe C  et al. FOXO1 competes with carbohydrate response element-binding protein (ChREBP) and inhibits thioredoxin-interacting protein (TXNIP) transcription in pancreatic beta cells. J Biol Chem 288:23194-202 (2013).
4. Ouyang W  et al. Novel Foxo1-dependent transcriptional programs control T(reg) cell function. Nature 491:554-9 (2012). ChIP .
5. Lin KK  et al. CD81 is essential for the re-entry of hematopoietic stem cells to quiescence following stress-induced proliferation via deactivation of the Akt pathway. PLoS Biol9:e1001148 (2011). IHC-P ; Human .
6. Wang L  et al. Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression. Proc Natl Acad Sci U S A 108:E803-12 (2011). ChIP ; Human .
7. de la Torre-Ubieta L  et al. A FOXO-Pak1 transcriptional pathway controls neuronal polarity.Genes Dev 24:799-813 (2010). WB ; Rat .
8. Ouyang W  et al. Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells. Nat Immunol 11:618-27 (2010). ChIP .
9. Allard D  et al. Akt Regulates the Survival of Vascular Smooth Muscle Cells via Inhibition of FoxO3a and GSK3. J Biol Chem 283:19739-47 (2008). WB ; Rat .

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FOXO1A antibody

Immunohistochemical analysis of paraffin-embedded intima cancer tissues using FOXO1 antibody Cat.-No AM06731PU-N with DAB staining. Mouse IgG1 3B6 Purified Hu, Ms E, ICC/IF, P, WB
0.1 mg / €410.00
  OriGene Technologies GmbH

FOXO1A (242-655) antibody

  FOXO1 / FKHR Mouse Monoclonal (aa242-655) (7h3) Antibody  
FOXO1A Mouse IgG1 7h3 Azide Free Hu P, WB
50 µg / €425.00
  OriGene Technologies, Inc.

FOXO1A antibody

  Mouse Monoclonal FoxO1/FKHR Antibody (83N7F8)  
Western Blot: FOXO1A Antibody (83N7F8) [TA337217] - WB detection of FOXO1A / FOXO1 protein in (A) Hela cells lysate, (B) Jurkat cell lysate, and © partial recombinant protein by using FOXO1A antibody at a concentration of 0.5 ug/ml for lysate and Mouse IgG2b 83N7F8 Purified Hu C, ICC/IF, P, WB
0.1 mg / €395.00
  OriGene Technologies, Inc.

FOXO1A antibody

  Mouse Monoclonal FOXO1 (C-terminus) Antibody  
Western blot detection of FOXO1(C-terminus) in A431 and Hela cell lysates using FOXO1(C-terminus) mouse mAb (1:1000 diluted).Predicted band size:70KDa.Observed band size: 70KDa. Mouse IgG2a 3F8-H8-A10 Purified WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

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