FOXO3 / FKHRL1 antibody

Principal name

FOXO3 / FKHRL1 antibody

Alternative names for FOXO3 / FKHRL1 antibody

FOXO3A, AF6q21 protein, Forkhead box protein O3, Forkhead in rhabdomyosarcoma-like 1

SwissProt ID

O43524 (Human), Q6EUW1 (Xenla)

Gene ID

2309 (FOXO3)

Available reactivities

Hu (Human), Ms (Mouse), Can (Canine), Por (Porcine), Rt (Rat), African clawed frog, Bov (Bovine), Chk (Chicken), Mky (Monkey), Xen (Xenopus), Hst (Hamster), Prim (Primate), Sh (Sheep), Bear

Available hosts

Rabbit, Mouse, Goat

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of FOXO3 / FKHRL1 antibody

This polyclol antibody recognizes human FOXO3A also known as forkhead box 03A, forkhead in rhabdomysacoma-like 1, and FKHRL1. FOXO3A is a member of the forkhead transcription factor family, containing a single forkhead domain, with a predicted molecular weight of approximately 71 kD. The FOXO3A protein is located in the cytoplasm when complexed to 14-3-3 protein; and in the nucleus when acting as a transcription factor for cell death genes. FOXO3A is widely expressed in the heart, brain, lung, liver, muscle, kidney, spleen, thymus, prostate, ovary, and small intestine. The FOXO3A protein triggers apoptosis by inducing cell death-specific genes. When survival factors are present, AKT1 phosphorylates FOXO3A leading to its association with 14-3-3 proteins and retention in the cytoplasm. Withdrawal of survival factors leads to dephosphorylation of FOXO3A and nuclear translocation which induces cell death. Overexpression of FOXO3A can cause growth suppression; while inhibition of FOXO3A has been reported to promote tumorigenesis under some conditions. FOXO3A acts at the G2/M checkpoint to activate D repair through the direct activation of proteins such as GADD45A. FOXO3A has also been shown to regulate erythroid differentiation. FOXO3A is modified at multiple phosphorylation sites (T32, S253, S315) and has been shown to interact with SMAD4, SMAD3, SMAD2, AKT1, 14-3-3 zeta, other proteins. This antibody has been shown to be useful for Western blotting.

General readings

Submitted (17-AUG-2004) MIPS, Ingolstaedter Landstr.1, D-85764 Neuherberg, GERMANY

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FOXO3 / FKHRL1 (C-term) antibody

  Goat Polyclonal Antibody against FOXO3A / FKHRL1  
TA302661 staining (0.5µg/ml) of Human Brain lysate (RIPA buffer, 35µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FOXO3 / FKHRL1 antibody

  Rabbit anti-FOXO3A (FKHRL1, Phospho-Ser253) polyclonal antibody(Phospho-specific)  
Western blot analysis of extracts from NIH/3T3 cells using FKHRL1 antibody (Lanes 1 and 2) and FKHRL1 (phospho-Ser253) antibody (Lanes 3 and 4). Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FOXO3 / FKHRL1 (N-term) antibody

  Rabbit Polyclonal FOXO3 Antibody  
Western blot analysis of FOXO3 in A-20 cell lysate with FOXO3 antibody at (A) 0.5 and (B) 1 ug/mL. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FOXO3 / FKHRL1 antibody

  Anti-FOXO3 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm, Nucleus. Positive control: Human cervical cancer tissue. Recommended dilution: 1/50-150  The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using FOXO3 antibody at dilution 1/22, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

FOXO3 / FKHRL1 antibody

  Anti-FOXO3 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm, Nucleus. Positive control: Human stomach and lung cancer tissue. Recommended dilution: 1/50-150  The image on the left is immunohistochemistry of paraffin-embedded Human stomach and lung cancer tissue using FOXO3 antibody at dilution 1/17, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

FOXO3 / FKHRL1 antibody

  Rabbit polyclonal FOXO3 Antibody (N-term)  
FOXO3  Antibody (N-term) (Cat. #TA324516) western blot analysis in Hela,MCF-7 cell line lysates (35ug/lane).This demonstrates the FOXO3  antibody detected the FOXO3  protein (arrow). Rabbit IgG Purified Hu, Ms P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

FOXO3 / FKHRL1 antibody

  Rabbit Polyclonal FKHRL1 Antibody  
Western blot analysis of FKHRL1 expression in serum treated NIH-3T3 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

FOXO3 / FKHRL1 antibody

  Rabbit Polyclonal FKHRL1 (Ser253) Antibody (Phospho-specific)  
Western blot analysis of FKHRL1 phosphorylation expression in serum treated NIH-3T3 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

FOXO3 / FKHRL1 antibody

  Rabbit Polyclonal anti-FOXO3A (FKHRL1) Antibody  
Jurkat cell  extract was resolved by electrophoresis, transferred to nitrocellulose, and probed with rabbit polyclonal antibody against FOXO3A. Proteins were visualized using a donkey anti-rabbit secondary conjugated to HRP and a chemiluminescence detection system. Rabbit IgG Poly6298 Purified Hu WB
50 µl / €325.00
  OriGene Technologies, Inc.

FOXO3 / FKHRL1 antibody

  Rabbit Polyclonal FOXO3A Antibody  
ELISA: FOXO3A Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

FOXO3 / FKHRL1 (361-460) antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 2H2 Purified Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

FOXO3 / FKHRL1 (361-460) antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 4E8 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

FOXO3 / FKHRL1 (361-460) antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 4F2 Purified Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

FOXO3 / FKHRL1 (361-460) antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 2C5 Purified Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

FOXO3 / FKHRL1 (361-460) antibody

Formalin-Fixed, Paraffin-Embedded Human Spleen stained FOXO3 / FKHRL1 Antibody Cat.-No AM31789PU-N at 5 µg/ml after heat-induced antigen retrieval. Mouse IgG2a 3C2 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

FOXO3 / FKHRL1 antibody

Western blot analysis of FOXO3a expression in lysate from Jurkat cells (Lane 1), Rat liver (Lane 2) and Rat kidney (Lane 3). Rabbit Aff - Purified Hu, Ms IP, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

FOXO3 / FKHRL1 (600-673) antibody

AP08296PU-N FOXO3 antibody staining of Formalin-Fixed Paraffin Embedded Human Skin at 10 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit IgG Aff - Purified Bov, Can, Chk, Hu, Mky, Ms, Rt, Xen P, WB
50 µg / €470.00
  Acris Antibodies GmbH

FOXO3 / FKHRL1 (221-270) antibody

Immunohistochemistry (IHC) analyzes of FoxO3 antibody (Cat.-No.: AP20683PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

FOXO3 / FKHRL1 pSer253 antibody

Immunohistochemistry analysis of Phospho-FoxO3 Antibody (Cat.-No AP20805PU-N) (pSer253) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

FOXO3 / FKHRL1 pSer253 antibody

Immunohistochemistry (IHC) analyzes of Phospho-FOXO3A antibody (pSer253) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

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