FPGS antibody

Principal name

FPGS antibody

Alternative names for FPGS antibody

Folylpolyglutamate synthase, Tetrahydrofolate synthase, Folylpoly-gamma-glutamate synthetase, Tetrahydrofolylpolyglutamate synthase

SwissProt ID

A6H751 (Bovin), P48760 (Mouse), Q05932 (Human)

Gene ID

2356 (FPGS)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of FPGS antibody

Folylpoly-gamma-glutamate synthetase (FPGS) catalyzes the addition of several equivalents of glutamic acid to the gamma-carboxyl group in the side chain of folate cofactors and analogs. Folylpoly-gamma-glutamate synthetase has three functions in folate homeostasis in mammals: polyglutamation prevents efflux of folate cofactors from the cell, it increases the binding of folate cofactors to some of the enzymes of folate interconversion and biosynthesis, and it appears to allow the accumulation of folates in the mitochondria that are required for glycine synthesis. Folylpoly-gamma-glutamate synthetase is widely expressed in human tumors and is tightly linked either to proliferation or to a lack of differentiation. The cytotoxicity of both thymidylate synthase and purine inhibitors requires continued inhibition of target for greater than one generation time, so that the integrative function of FPGS adds considerably to the efficiency of folate antimetabolites.

9 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FPGS antibody

AP15565PU FPGS antibody staining of Human Breast Carcinoma. Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

FPGS antibody

AP15565PU FPGS antibody staining of Human Breast Carcinoma. Rabbit Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

FPGS antibody

AP15565PU FPGS antibody staining of Human Breast Carcinoma. Rabbit Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

FPGS antibody

Western blot analysis of FPGS Antibody (Center) (AP17399PU-N) in K562, A2058 cell line lysates (35 µg/lane). FPGS (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

FPGS antibody

FPGS Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

FPGS antibody

FPGS Rabbit IgG Hu P
0.1 ml / €310.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

FPGS

FPGS Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

FPGS

FPGS Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

FPGS overexpression lysate

FPGS overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

9 Item(s)

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