FPR2 / FPRL1 antibody

Principal name

FPR2 / FPRL1 antibody

Alternative names for FPR2 / FPRL1 antibody

N-formyl peptide receptor 2, FMLP-R-I, FPRH1, RFP, LXA4R, FMLP-related receptor I, Formyl peptide receptor-like 1, Lipoxin A4 receptor

SwissProt ID

O08790 (Mouse), P25090 (Human)

Gene ID

2358 (FPR2)

Available reactivities

Hu (Human), Ms (Mouse), Can (Canine), Mky (Monkey), Prim (Primate), Rb (Rabbit), Rt (Rat)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Paraffin Sections (P), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunoprecipitation (IP)

Background of FPR2 / FPRL1 antibody

Chemotactic factors from both Gram-positive and Gram-negative bacteria are short peptides with N-formyl methionine at the N-terminus (extensively reviewed in reference 1). These peptides are released from bacteria during infection and activate formyl peptide receptor (FPR), a member of G-protein coupled receptors (GPCRs). In human, the FPR family consists mainly of three receptors, FPR1, FPR2/ALX (formerly FPRL1), and FPR3 (formerly FPRL2) which all couple to the Gi subtype of G-proteins and ultimately lead to the activation of phospholipase C and intracellular Ca2+ increase. FPRL1 or FPR2/ALX as commonly called is a seven transmembrane protein like all GPCRs. This receptor was origilly cloned by screening a HL60 neutrophil cD library with a FPR1 cD probe. FPR2/ALX shares 69% identity with FPR1 and despite its high homology, it displays relatively low affinity for fmlf, the most potent N-formyl peptide released by bacteria. FPR1 was origilly found in neutrophils and later found to be distributed myeloid and non-myeloid cells as is the case for FPR2/ALX and FPR3 (FPR3 though is not expressed in neutrophils). FPR1 is also expressed in multiple organs and tissues including epithelial cells in organs with secretory functions, endocrine cells, liver hepathocytes, smooth muscle cells and endothelial cells, brain spil cord and both motor and sensory neurons. FPR2/ALX has a similar tissue distribution to that of FPR1. While N-formyl peptides were the first peptides found to activate these receptors, the ligand diversity for FPR has proven to be quite broad and demonstrates to be both pro- and anti-inflammatory. They include peptidic ligands origiting from bacterial and viral sources (including HIV), endogenous ligands such as chemokines and annexins, short peptides associated with inflammation and infection. Interestingly, b-amyloid peptide, a known marker for Alzheimer’s disease activates FPR2/ALX thereby directly linking these receptors to the neurodegenerative disease. Lipoxin A4 (LXA4) is the first identified endogenous ligand for FPR2/ALX and is an eicosanoid with potent anti-inflammatory characteristics. Considering that FPR2/ALX can be activated by two different types of ligands, this receptor can be categorized in two different GPCR subgroups: Formylpeptide Receptors and Leukotriene Receptors.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FPR2 / FPRL1 antibody

Figure 1. FACS analysis of BOSC23 cells using GM1D6 Cat.-No DM1216. BOSC23 cells were transiently transfected with an expression vector encodingeither FPRL1 (red curve) or an irrelevant protein (control transfectant: black curve). Binding of GM1D6 was detected with a PE-conjugated secondary antibody. A positive signal was obtained only with FPRL1 transfected cells. Mouse IgG1 GM-1D6 Purified Hu E, F, ICC/IF
0.1 mg / €330.00
  Acris Antibodies GmbH

FPR2 / FPRL1 (2nd extracel. dom.) antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Can, Hu, Mky, Prim P
50 µg / €345.00
  OriGene Technologies, Inc.

FPR2 / FPRL1 (N-term, extracel. dom.) antibody

Anti-FPR2 / FPRL1 antibody IHC of human spleen, neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 20-40 ug/ml. Rabbit Aff - Purified Hu, Mky, Prim, Rb P
50 µg / €345.00
  OriGene Technologies, Inc.

FPR2 / FPRL1 antibody

Predicted cell location: Cytoplasm. Positive control: Human cervical cancer tissue. Recommended dilution: 1/20-100  The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using FPR2 antibody at dilution 1/17, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

FPR2 / FPRL1 antibody

Predicted cell location: Cytoplasm. Positive control: Human brain tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using FPR2 antibody at dilution 1/25, on the right is treated with the synthetic peptide. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

FPR2 / FPRL1 antibody

Western blot analysis of HL-60 (lanes 1 and 3) and K562 (lanes 2 and 4) human leukemia cell lysates: 1, 2. Anti-Human FPR2/ALX (extracellular) antibody, (1:200). 3, 4. Anti-Human FPR2/ALX (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

FPR2 / FPRL1 (C-term) antibody

Figure 1. Western blot analysis of extracts from HL60 cells using anti-FPRL1 antibody (clone C4F9) at 1 µg/ml. Mouse IgG1 C4F9 Purified Hu E, WB
0.5 mg / €450.00
  Acris Antibodies GmbH

FPR2 / FPRL1 (C-term) antibody

Figure 1. Western blot analysis of extracts from HL60 cells using anti-FPRL1 antibody (clone B4D9B10) at 1 µg/ml. Mouse IgG1 B4D9B10 Purified Hu E, WB
0.5 mg / €450.00
  Acris Antibodies GmbH

FPR2 / FPRL1 (Extracell. Dom) antibody

Western blot analysis of extracts from 293 cells transfected with FPRL1 DNA using anti-FPRL1 antibody (Clone 3D7) at 1/1000 (1μg/ml) dilution. Mouse IgG1 3D7 Purified Hu E, WB
0.5 mg / €540.00
  Acris Antibodies GmbH

FPR2 / FPRL1 (Extracell. Dom) antibody

Western blot analysis of extracts from 293 cells transfected with FPRL1 DNA using anti-FPRL1 antibody (Clone B7H7) at 1/2000 (0.5 μg/ml) dilution. Mouse IgG1 B7H10 Purified Hu E, WB
0.5 mg / €540.00
  Acris Antibodies GmbH

FPR2 / FPRL1 (C-term) antibody

Analysis of HL-60 cells using 1:600 diluted fluorescence labelled anti-FPRL1 antibody (green). Nuclei have been labelled with PI (red). Rabbit Azide Free Hu ICC/IF, WB
0.5 mg / €680.00
  Acris Antibodies GmbH

FPR2 / FPRL1 (C-term) antibody

Analysis of HL-60 cells using 1:600 diluted fluorescence labelled anti-FPRL1 antibody (green). Nuclei have been labelled with PI (red). Rabbit Azide Free Hu ICC/IF, WB
0.1 mg / €360.00
  Acris Antibodies GmbH

FPR2 / FPRL1 (2nd extracell. loop) antibody

Immunofluorescent analysis of HL-60 cells using anti-FPRL1 antibody (green). Nucleus have been labeled with PI (red). Rabbit Aff - Purified Hu F, ICC/IF, WB
0.5 mg / €680.00
  Acris Antibodies GmbH

FPR2 / FPRL1 (2nd extracell. loop) antibody

Immunofluorescent analysis of HL-60 cells using anti-FPRL1 antibody (green). Nucleus have been labeled with PI (red). Rabbit Aff - Purified Hu F, ICC/IF, WB
0.1 mg / €360.00
  Acris Antibodies GmbH

FPR2 / FPRL1 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human Heart tissue stained with FPR2 / FPRL1 Antibody Cat.-No AP33201PU-N at 5 μg/ml after heat-induced antigen retrieval. Rabbit Aff - Purified Hu ICC/IF, P, WB
50 µg / €630.00
  Acris Antibodies GmbH

FPR2 / FPRL1 antibody

FPR2 / FPRL1 Mouse Hu WB
50 µg / €370.00
  Abnova Taiwan Corp.

FPR2 / FPRL1 antibody

Immunoprecipitation of FPR2 transfected lysate using anti-FPR2 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with FPR2 MaxPab mouse polyclonal antibody (B01) (H00002358-B01). Rabbit Serum Hu E(detection), IP
0.1 ml / €380.00
  Abnova Taiwan Corp.

FPR2 / FPRL1 antibody

Western Blot analysis of FPR2 expression in transfected 293T cell line (H00002358-T02) by FPR2 MaxPab polyclonal antibody.

Lane 1: FPRL1 transfected lysate(39.00 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

FPR2 / FPRL1 antibody

FPR2 / FPRL1 Mouse IgG2a 2D8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

FPR2 / FPRL1 antibody

FPR2 / FPRL1 Mouse IgG2a 2G8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

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