FRAT1 antibody

Principal name

FRAT1 antibody

Alternative names for FRAT1 antibody

FRAT-1, Proto-oncogene FRAT1, Frequently rearranged in advanced T-cell lymphomas

SwissProt ID

P70339 (Mouse), Q92837 (Human)

Gene ID

10023 (FRAT1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Dot blot (Dot), Immunoprecipitation (IP)

Background of FRAT1 antibody

FRAT1 and FRAT2 were originally characterized as proteins frequently rearranged in advanced T cell lymphoma, and they have since been identified as proto-oncogenes involved in tumorigenesis. These proteins share significant homology with the Xenopus glycogen synthase kinase-3 (xGSK-3) binding protein, which is designated GBP and is essential for the formation of the dorsal-ventral axis during embryonic development. Establishment of these embryonic axes is mediated by the Wnt intracellular signaling pathway. Wnt signaling is regulated in part by the activity of GSK-3, which phosphorylates and thereby facilitates the degradation of ?catenin. GBP binds to GSK-3 and inhibits this phosphorylation, resulting in the accumulation of ?catenin and the subsequent transcription of Wnt target genes. Like GBP, FRAT2 has been shown to bind xGSK-3, suggesting that FRAT1 and FRAT2 may be GSK-3 regulatory proteins.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FRAT1 (C-term) antibody

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with FRAT1 antibody (C-term) (AP11407PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

FRAT1 antibody

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with FRAT1 antibody (Center) (AP11408PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

FRAT1 antibody

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with FRAT1 polyclonal antibody ( Cat # PAB3083 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

FRAT1 antibody

Western blot analysis of FRAT1 ( arrow ) using rabbit FRAT1 polyclonal antibody ( Cat # PAB3084 ) . 293 cell lysates ( 2 µg/lane ) either nontransfected ( Lane 1 ) or transiently transfected with the FRAT1 gene ( Lane 2 ) ( Origene Technologies ) . Rabbit Hu C, E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

FRAT1 antibody

Western Blot: FRAT1 Antibody [NBP1-31213] - Western blot analysis of FRAT1 Antibody on: A:A431 12% SDS PAGE diluted at 1:1000 Rabbit IgG Hu Dot, ICC/IF, P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

FRAT1

FRAT1 Human
10 µg / €380.00
  Abnova Taiwan Corp.

FRAT1

FRAT1 Human
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

FRAT1 overexpression lysate

FRAT1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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