FRAT2 antibody

Principal name

FRAT2 antibody

Alternative names for FRAT2 antibody

GSK-3-binding protein Frat-2

SwissProt ID

O75474 (Human), Q8K025 (Mouse)

Gene ID

23401 (FRAT2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Goat, Mouse, Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of FRAT2 antibody

FRAT1 and FRAT2 were originally characterized as proteins frequently rearranged in advanced T cell lymphoma, and they have since been identified as proto-oncogenes involved in tumorigenesis. These proteins share significant homology with the Xenopus glycogen synthase kinase-3 (xGSK-3) binding protein, which is designated GBP and is essential for the formation of the dorsal-ventral axis during embryonic development. Establishment of these embryonic axes is mediated by the Wnt intracellular signaling pathway. Wnt signaling is regulated in part by the activity of GSK-3, which phosphorylates and thereby facilitates the degradation of ?catenin. GBP binds to GSK-3 and inhibits this phosphorylation, resulting in the accumulation of ?catenin and the subsequent transcription of Wnt target genes. Like GBP, FRAT2 has been shown to bind xGSK-3, suggesting that FRAT1 and FRAT2 may be GSK-3 regulatory proteins.

General readings

Lee, D.Y., et al. Menopause 17(5):1064-1070(2010)
Liu, G.P., et al. Neurobiol. Aging 29(9):1348-1358(2008)
Stoothoff, W.H., et al. J. Biol. Chem. 280(1):270-276(2005)
Deloukas, P., et al. Nature 429(6990):375-381(2004)
Freemantle, S.J., et al. Gene 291 (1-2), 17-27 (2002)

8 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FRAT2 (C-term) antibody

TA302774 staining (2µg/ml) of Human Heart lysate (RIPA buffer, 30µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FRAT2 (C-term) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human bladder carcinoma reacted with FRAT2 Antibody (C-term) Cat.-No AP51723PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu ICC/IF, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

FRAT2 antibody

Western Blot analysis of FRAT2 expression in transfected 293T cell line (H00023401-T01) by FRAT2 MaxPab polyclonal antibody.

Lane 1: FRAT2 transfected lysate(25.63 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

FRAT2 antibody

FRAT2 polyclonal antibody ( Cat # PAB6138 ) staining ( 2 µg/ml ) of human heart lysate ( RIPA buffer, 30 µg total protein per lane ). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

FRAT2 antibody

NB 100-1009 staining (2µg/ml) of Human Heart lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

FRAT2

FRAT2 Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

FRAT2 293T Cell Transient Overexpression Lysate(Denatured)

FRAT2 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

FRAT2 overexpression lysate

FRAT2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

8 Item(s)

per page
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