FRMPD4 antibody

Principal name

FRMPD4 antibody

Alternative names for FRMPD4 antibody

KIAA0316, PDZD10, PDZK10, Preso, FERM and PDZ domain-containing protein 4, PDZ domain-containing protein 10, PSD-95-interacting regulator of spine morphogenesis

SwissProt ID

A2AFR3 (Mouse), Q14CM0 (Human)

Gene ID

9758 (FRMPD4)

Available reactivities

Hu (Human)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB)

Background of FRMPD4 antibody

The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD4, also known as Preso, also contains another protein interaction domain termed WW (domain with two conserved Trp residues) at its amino terminus. It was identified through a yeast two-hybrid screen using the PDZ domain of PSD-95 as bait and is highly expressed in multiple regions of the brain and is enriched in the postsynaptic density (PSD) fractions. Overexpression of FRMPD4 in cultured hippocampal neurons significantly increased the linear density of dendritic spines without changing their length and width; conversely, knockdown experiments using RNAi caused a decrease in spine density, indicating FRMPD4 positively regulates dendritic spine density but not morphology. The decreased level of FRMPD4 also resulted in reduced levels of excitatory synaptic transmission, suggesting that FRMPD4 is required for maintenance of excitatory synaptic transmission.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FRMPD4 antibody

Western blot analysis of FRMPD4 in SK-N-SH cell lysate with FRMPD4 antibody at (A) 1 and (B) 2 µg/ml. Rabbit IgG Aff - Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FRMPD4 antibody

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Hu E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

FRMPD4 Control Peptide

FRMPD4
50 µg / €160.00
  Acris Antibodies GmbH

FRMPD4 antibody

Immunohistochemistry-Paraffin: FRMPD4 Antibody [NBP1-93646] Immunohistochemical staining of human testis shows strong cytoplasmic and nuclear positivity in seminiferus ducts. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

FRMPD4

FRMPD4 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

FRMPD4 overexpression lysate

FRMPD4 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

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