FRS2 antibody

Principal name

FRS2 antibody

Alternative names for FRS2 antibody

FGFR substrate 2, SNT1, SNT-1, Fibroblast growth factor receptor substrate 2, FGFR-signaling adaptor SNT, Suc1-associated neurotrophic factor target 1

SwissProt ID

Q8C180 (Mouse), Q8WU20 (Human)

Gene ID

10818 (FRS2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine)

Available hosts

Rabbit, Mouse, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunoprecipitation (IP), ELISA (detection) (E(detection))

Background of FRS2 antibody

FGFs (Fibroblast Growth Factors) bind to FGF receptors (FGFRs) monovalently, and FGF receptor dimerization and activation is mediated by multivalent interactions between heparin sulfate proteoglycans and FGF. Upon activation, receptor tyrosine kinases undergo rapid autophosphorylation on numerous tyrosine residues. Autophosphorylation sites located within the catalytic domain are crucial for stimulation of kinase activity, while autophosphorylation sites located in other regions are usually involved in the recruitment of cellular target proteins. Fibroblast growth factor or nerve growth factor (NGF) stimulation leads to tyrosine phosphorylation of the FGF Receptor Substrate 2 (FRS2) docking proteins. FRS2 is also designated SNT (Suc1 associated neurotrophic factor target protein). Two structurally similar forms of FRS2 are: FRS2alpha (SNT1) and FRS2 beta(SNT2, FRS3). FRS functions as a lipid-anchored docking protein that is tyrosine phosphorylated and recruited to FGFR upon FGF stimulation. FRS2 plays an important role in linking FGF and NGF with the Ras/MAPK signaling pathway, thus relaying information from the cell surface to the nucleus. FRS2 contains both a consensus myristylation sequence, involved in its recruitment to the cell membrane and a putative phosphotyrosine binding (PTB) domain in its amino-terminus. The interaction of FRS2 with FGFR1 occurs via the PTB domain of FRS2 binding to a 12-residue segment in the juxtamembrane region of FGFR1. FRS2 alpha contains four binding sites for the adaptor protein Grb2 and two binding sites for the protein tyrosine phosphatase Shp2. FGF stimulation leads to phosphorylation of Shp2 on a tyrosine residue forming a complex with an additional molecule of Grb2. Grb2/Sos complexes are thus recruited directly and indirectly via Shp2 upon tyrosine phosphorylation of FRS2alpha in response to growth factor stimulation. It has been shown that FRS2 proteins are tyrosine phosphorylated in response to activation of the RET receptor, a tyrosine kinase that functions as the signal transducing receptor for the GDNF.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FRS2 antibody

Western blot analysis of extracts from HepG2 cells, using FRS2 (Ab-196) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

FRS2 antibody

Western blot analysis of FRS2 expression in HUVEC whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

FRS2 antibody

Western blot analysis on COS7 cell lysate using FRS2 Antibody Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

FRS2 antibody

TA341377 (0.1µg/ml) staining of 3T3-L1 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Purified Bov, Can, Ms, Por WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FRS2 pTyr436 antibody

Immunohistochemical analysis of paraffin-embedded human brain tissue using FRS2 (Phospho-Tyr436) antibody AP55788PU-N (left)or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu, Ms P, WB
0.1 ml / €340.00
  Acris Antibodies GmbH

FRS2 pTyr436 antibody

Immunohistochemical analysis of paraffin-embedded human brain tissue using FRS2 (Phospho-Tyr436) antibody AP55788PU-N (left)or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu, Ms P, WB
50 µl / €270.00
  Acris Antibodies GmbH

FRS2 antibody

FRS2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

FRS2 antibody

Western Blot analysis of FRS2 expression in transfected 293T cell line (H00010818-T01) by FRS2 MaxPab polyclonal antibody.

Lane 1: FRS2 transfected lysate(56.32 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

FRS2 antibody

FRS2 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

FRS2 antibody

Immunoprecipitation of FRS2 transfected lysate using anti-FRS2 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with FRS2 MaxPab mouse polyclonal antibody (B01) (H00010818-B01). Rabbit Serum Hu E(detection), IP
0.1 ml / €380.00
  Abnova Taiwan Corp.

FRS2 antibody

Western Blot analysis of FRS2 expression in transfected 293T cell line by FRS2 monoclonal antibody (M02), clone 1F7-1D6.

Lane 1: FRS2 transfected lysate(57.5 KDa).
Lane 2: Non-transfected lysate. Mouse IgG1 1F7-1D6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

FRS2 antibody

FRS2 Mouse IgG1 S1 Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

FRS2 antibody

Western blot analysis of FRS2 expression in rat kidney tissue lysate. Rabbit Hu, Ms, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

FRS2 pTyr436 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using FRS2 (Phospho-Tyr436) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P, WB
50 µg / €205.00
  Assay Biotech

FRS2 pTyr436 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using FRS2 (Phospho-Tyr436) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P, WB
0.1 mg / €310.00
  Assay Biotech

FRS2 antibody

Western blot analysis of extracts from HepG2 cells, using FRS2 (Ab-196) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
50 µg / €205.00
  Assay Biotech

FRS2 antibody

Western blot analysis of extracts from HepG2 cells, using FRS2 (Ab-196) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €310.00
  Assay Biotech

FRS2 antibody

Western Blot: FRS2 Antibody [NBP1-45579] - Western blot analysis of FRS2 expression with Rat kidney tissue lysate. Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

FRS2 (transcript variant 1)

FRS2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

FRS2

FRS2 Human Purified
10 µg / €380.00
  Abnova Taiwan Corp.

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