FUS / TLS antibody

Principal name

FUS / TLS antibody

Alternative names for FUS / TLS antibody

POMp75, RNA-binding protein FUS, Translocated in liposarcoma protein, 75 kDa DNA-pairing protein, Oncogene FUS, Oncogene TLS

SwissProt ID

P35637 (Human), P56959 (Mouse), Q28009 (Bovin)

Gene ID

2521 (FUS), 233908 (Fus)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Can (Canine), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), PLA/Proximity ligation assay (PLA), Enzyme Immunoassay (E), Flow Cytometry (F), Frozen Sections (C)

Background of FUS / TLS antibody

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Involved in placental, cardiac, hepatic and embryonic development. NCOA6 is over-expressed in several breast cancer cell lines.

General readings

Kim, S.H., et al. J. Biol. Chem. 285(44):34097-34105(2010)
Mackenzie, I.R., et al. Lancet Neurol 9(10):995-1007(2010)
Yan, J., et al. Neurology 75(9):807-814(2010)
Waibel, S., et al. Neurology 75(9):815-817(2010)
Baumer, D., et al. Neurology 75(7):611-618(2010)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FUS / TLS antibody

WB Suggested Anti-FUS Antibody; Positive Control: Lane 1: 5ug mouse brain cytoplasm Lane 2: 5ug mouse brain nucleus; Primary Antibody Dilution: 1: 1000; Secondary Antibody: Anti rabbit - IR-dye; Secondry Antibody Dilution: 1: 10, 000; Rabbit IgG Purified Bov, Can, Hu, Ms, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

FUS / TLS (C-term) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma stained with FUS Antibody (C-term) Cat.-No AP51735PU-Nfollowed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the FUS antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu, Ms F, ICC/IF, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

FUS / TLS antibody

Human Intestine; Rabbit Anti-FUS Antibody. Catalog Number: ARP40278. Paraffin Embedded Tissue: Human Intestine. Cellular Data: Epithelial cells of intestinal villas. Antibody Concentration: 4.0-8.0 ug/ml. Magnification: 400X; FUS antibody - N-terminal region (ARP40278_P050) in Human Intestine cells using Immunohistochemistry Rabbit Purified Bov, Chk, Hu, Ms, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

FUS / TLS antibody

Western Blot: FUS Antibody - Western blot analysis of FUS in Jurkat nuclear extracts. Rabbit Purified Bov, Hu, Ms C, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

FUS / TLS antibody

FUS / TLS Rabbit Hu, Ms IP, WB
0.1 ml / €400.00
  Abnova Taiwan Corp.

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